Maternal, fetal, and pregnancy characteristics
| . | Participant 1 . | Participant 2 . | Participant 3 . |
|---|---|---|---|
| Maternal age, y | 30 | 24 | 22 |
| Maternal race, ethnicity | White, non-Hispanic | Black, non-Hispanic | White, non-Hispanic |
| Maternal medical history | — | Subclinical hypothyroidism, obesity, and iron deficiency anemia | Type 1 diabetes and obesity |
| Obstetrical history | G1P0000 | G2P0010 | G2P1001, PIH |
| Antenatal course | Uncomplicated | Gestational diabetes, bacteriuria | COVID-19 infection |
| Gestational age at HELLP diagnosis | 27 wk, 6 d | 26 wk, 3 d | 25 wk, 6 d |
| Urine protein-to-creatinine ratio | 2.0 | 4.5 | 5.7 |
| Fetal presentation | Severe IUGR with IAEDF | Severe IUGR | IUGR |
| HTN | Severe | Severe | Severe |
| Supportive measures | Betamethasone, magnesium, and antihypertensives | Dexamethasone, magnesium, and antihypertensives | Betamethasone magnesium and antihypertensives |
| Time from eculizumab to delivery, h | 25.5 | 59 | 32 |
| Delivery mode | Low transverse cesarean delivery | Classical cesarean delivery | Mid-segment transverse cesarean delivery |
| Delivery indication | Nonreassuring fetal heart tracing | Nonreassuring fetal heart tracing | Nonreassuring fetal status, headache, and increased creatinine |
| Gestational age delivery | 28 wk, 0 d | 26 wk, 6 d | 27 wk, 1 d |
| EBL, mL | 760 | 900 | 1200 |
| Maternal LOS (postpartum day) | 4 | 4 | 4 |
| Apgar (1, 5) | 5, 7 | 1, 7 | 4, 8 |
| Birth weight, g | 780 | 740 | 710 |
| Fetal sex | F | M | F |
| Neonatal complications | Apnea of prematurity, bronchopulmonary dysplasia, anemia, and umbilical line–associated aortic thrombus | Apnea of prematurity, chronic lung disease, anemia, ventriculomegaly, poor enteral feeding, and steroid-induced adrenal insufficiency | Bronchopulmonary dysplasia, pulmonary HTN, anemia, steroid-induced adrenal insufficiency, and umbilical line–associated aortic thrombus |
| Neonatal interventions | CPAP, pRBC transfusions, TPN, heparin, and gastric tube | Intubation, gastric tube, and pRBC transfusions | Intubation, iNO, gastric tube, pRBC transfusions, and PDA ligation |
| NICU LOS, d | 50 | 87 | 500 |
| . | Participant 1 . | Participant 2 . | Participant 3 . |
|---|---|---|---|
| Maternal age, y | 30 | 24 | 22 |
| Maternal race, ethnicity | White, non-Hispanic | Black, non-Hispanic | White, non-Hispanic |
| Maternal medical history | — | Subclinical hypothyroidism, obesity, and iron deficiency anemia | Type 1 diabetes and obesity |
| Obstetrical history | G1P0000 | G2P0010 | G2P1001, PIH |
| Antenatal course | Uncomplicated | Gestational diabetes, bacteriuria | COVID-19 infection |
| Gestational age at HELLP diagnosis | 27 wk, 6 d | 26 wk, 3 d | 25 wk, 6 d |
| Urine protein-to-creatinine ratio | 2.0 | 4.5 | 5.7 |
| Fetal presentation | Severe IUGR with IAEDF | Severe IUGR | IUGR |
| HTN | Severe | Severe | Severe |
| Supportive measures | Betamethasone, magnesium, and antihypertensives | Dexamethasone, magnesium, and antihypertensives | Betamethasone magnesium and antihypertensives |
| Time from eculizumab to delivery, h | 25.5 | 59 | 32 |
| Delivery mode | Low transverse cesarean delivery | Classical cesarean delivery | Mid-segment transverse cesarean delivery |
| Delivery indication | Nonreassuring fetal heart tracing | Nonreassuring fetal heart tracing | Nonreassuring fetal status, headache, and increased creatinine |
| Gestational age delivery | 28 wk, 0 d | 26 wk, 6 d | 27 wk, 1 d |
| EBL, mL | 760 | 900 | 1200 |
| Maternal LOS (postpartum day) | 4 | 4 | 4 |
| Apgar (1, 5) | 5, 7 | 1, 7 | 4, 8 |
| Birth weight, g | 780 | 740 | 710 |
| Fetal sex | F | M | F |
| Neonatal complications | Apnea of prematurity, bronchopulmonary dysplasia, anemia, and umbilical line–associated aortic thrombus | Apnea of prematurity, chronic lung disease, anemia, ventriculomegaly, poor enteral feeding, and steroid-induced adrenal insufficiency | Bronchopulmonary dysplasia, pulmonary HTN, anemia, steroid-induced adrenal insufficiency, and umbilical line–associated aortic thrombus |
| Neonatal interventions | CPAP, pRBC transfusions, TPN, heparin, and gastric tube | Intubation, gastric tube, and pRBC transfusions | Intubation, iNO, gastric tube, pRBC transfusions, and PDA ligation |
| NICU LOS, d | 50 | 87 | 500 |
Severe HTN is defined as systolic blood pressure ≥160 mm Hg and/or diastolic blood pressure ≥110 mm Hg.
CPAP, continuous positive pressure ventilation; EBL, estimated blood loss; F, female; HTN, hypertension; IAEDF, intermittent absent end-diastolic flow; iNo, inhaled nitric oxide; IUGR, intrauterine growth restriction; LOS, length of stay; M, male; NICU, neonatal intensive care unit; PDA, patent ductus arteriosus; PIH, pregnancy induced hypertension; pRBC, packed red blood cell; TPN, total parenteral nutrition.