Recommended assessment of IR
| IR . | Assessment . | Interval . |
|---|---|---|
| Clinical | Absolute numbers of NK cells, CD4+ and CD8+ T cells, B cells, and T-regs | 3, 6, 9, 12, 18, and 24 months after HSCT; subsequently at regular intervals until normal |
| Antibody titers (to immunization antigens such as tetanus, diphtheria, and hepatitis) | Assess antibody titers 4-6 weeks after reimmunization | |
| Research | Functional T-cell assays | At regular intervals after 6 months until normalized to define pace of reconstitution |
| Virus specific responses | ||
| TREC and KREC evaluation | ||
| T-cell receptor repertoire | ||
| B-cell receptor diversity |
| IR . | Assessment . | Interval . |
|---|---|---|
| Clinical | Absolute numbers of NK cells, CD4+ and CD8+ T cells, B cells, and T-regs | 3, 6, 9, 12, 18, and 24 months after HSCT; subsequently at regular intervals until normal |
| Antibody titers (to immunization antigens such as tetanus, diphtheria, and hepatitis) | Assess antibody titers 4-6 weeks after reimmunization | |
| Research | Functional T-cell assays | At regular intervals after 6 months until normalized to define pace of reconstitution |
| Virus specific responses | ||
| TREC and KREC evaluation | ||
| T-cell receptor repertoire | ||
| B-cell receptor diversity |
KRECs, Kappa-deleting recombination excision circles; NK cells, natural killer cells; TRECs, T-cell receptor excision circles; T-regs, regulatory T cells.