Recommended assessment of additional organ functions
| Organ . | Assessment . | Interval . |
|---|---|---|
| Growth | Height, weight, and body mass index | Yearly ×2 |
| Hormone levels if short stature (IGF-1 and IGFBP-3) | Subsequently yearly if abnormal and within growth period | |
| Bone age | ||
| Thyroid function | Thyroid-stimulating hormone | At 6 months, 1 year, and then annually |
| Free thyroxine level | ||
| Glucose metabolism | Fasting blood sugar | Annual |
| Glucose tolerance test | As needed | |
| Lipid metabolism | Fasting lipid panel | Annual |
| Bone health | Vitamin D3 level | Annual |
| Bone mineral density | 2 years and subsequently if intervention planned | |
| Dental health | Dental evaluation | Annual |
| Visual function | Vision test | Annual |
| Glaucoma screening | ||
| Retinal vessel assessment | ||
| Iron accumulation | Serum ferritin and transferrin saturation | Before intervention |
| Cardiac and liver MRI | 6 months, 1 year, and yearly until normal with therapy/phlebotomy |
| Organ . | Assessment . | Interval . |
|---|---|---|
| Growth | Height, weight, and body mass index | Yearly ×2 |
| Hormone levels if short stature (IGF-1 and IGFBP-3) | Subsequently yearly if abnormal and within growth period | |
| Bone age | ||
| Thyroid function | Thyroid-stimulating hormone | At 6 months, 1 year, and then annually |
| Free thyroxine level | ||
| Glucose metabolism | Fasting blood sugar | Annual |
| Glucose tolerance test | As needed | |
| Lipid metabolism | Fasting lipid panel | Annual |
| Bone health | Vitamin D3 level | Annual |
| Bone mineral density | 2 years and subsequently if intervention planned | |
| Dental health | Dental evaluation | Annual |
| Visual function | Vision test | Annual |
| Glaucoma screening | ||
| Retinal vessel assessment | ||
| Iron accumulation | Serum ferritin and transferrin saturation | Before intervention |
| Cardiac and liver MRI | 6 months, 1 year, and yearly until normal with therapy/phlebotomy |
IGF-1, insulin-like growth factor 1; IGFBP-3, insulin-like growth factor binding protein-3.