Fibrinolytic parameters and markers of fibrinogen and FV breakdown
| . | Nonbleeding term pregnant controls (N = 20) . | AOC (N = 12) . | Severe PPH without AOC (N = 21) . | AOC vs non-AOC P value . |
|---|---|---|---|---|
| Fibrinogen and FV breakdown products | ||||
| Fragments D and Y present | 0 | 10 (83) | 1 (5) | <.0001 |
| n (%) | ||||
| Breakdown products on reducing gel | 1 (5) | 12 (100) | 3 (14) | <.0001 |
| n (%) | ||||
| Decreased FV heavy chain | 1 (5) | 10 (83) | 0 (0) | <.0001 |
| n (%) | ||||
| Fibrin clot structure | ||||
| Fiber length, μM | 3206 (3076-3422) | 2881 (2678-3142) | 2972 (2776-3118) | .62 |
| Med (IQR) range | 2977-3530 | 1984-3235 | 2603-3584 | |
| Pore area, μM2 | 19.8 (18.2-23.0) | 25.0 (20.7-28.3) | 25.7 (22.9-28.7) | .79 |
| Med (IQR) range | (17.1-27.9) | 4.2-31.0 | 15.6-34.5 | |
| Number of pores, N | 346.4 (301.7-401.5) | 259.4 (230.7-292.4) | 257.6 (234.0-313.5) | .89 |
| Med (IQR) range | 273.3-434.0 | 141.7-370.0 | 183.0-476 | |
| Number of intersections, N | 1135.0 (1023.5-1254.0) | 956.5 (878.2-1117.5) | 951.5 (867.9-1052.0) | .90 |
| Med (IQR) range | 986.0-1384.0 | 665.0-1231.0 | 764.7-1399.0 | |
| Characterized length, μM | 3.03 (2.91-3.15) | 3.22 (2.94-3.36) | 3.26 (3.13-3.38) | .60 |
| Med (IQR) range | 2.73-3.24 | 2.77-3.63 | 2.80-3.62 | |
| Fiber thickness, μM | 1.90 (1.87-2.02) | 2.19 (1.0-2.37) | 2.08 (1.97-2.36) | .51 |
| Med (IQR) range | 1.72-2.27 | 1.89-2.82 | 1.38-2.59 | |
| Intersection density, ints/μM2 | 0.064 (0.058-0.071) | 0.054 (0.040-0.063) | 0.054 (0.049-0.060) | .93 |
| Med (IQR) range | 0.056-0.078 | 0.038-0.070 | 0.043-0.079 | |
| . | Nonbleeding term pregnant controls (N = 20) . | AOC (N = 12) . | Severe PPH without AOC (N = 21) . | AOC vs non-AOC P value . |
|---|---|---|---|---|
| Fibrinogen and FV breakdown products | ||||
| Fragments D and Y present | 0 | 10 (83) | 1 (5) | <.0001 |
| n (%) | ||||
| Breakdown products on reducing gel | 1 (5) | 12 (100) | 3 (14) | <.0001 |
| n (%) | ||||
| Decreased FV heavy chain | 1 (5) | 10 (83) | 0 (0) | <.0001 |
| n (%) | ||||
| Fibrin clot structure | ||||
| Fiber length, μM | 3206 (3076-3422) | 2881 (2678-3142) | 2972 (2776-3118) | .62 |
| Med (IQR) range | 2977-3530 | 1984-3235 | 2603-3584 | |
| Pore area, μM2 | 19.8 (18.2-23.0) | 25.0 (20.7-28.3) | 25.7 (22.9-28.7) | .79 |
| Med (IQR) range | (17.1-27.9) | 4.2-31.0 | 15.6-34.5 | |
| Number of pores, N | 346.4 (301.7-401.5) | 259.4 (230.7-292.4) | 257.6 (234.0-313.5) | .89 |
| Med (IQR) range | 273.3-434.0 | 141.7-370.0 | 183.0-476 | |
| Number of intersections, N | 1135.0 (1023.5-1254.0) | 956.5 (878.2-1117.5) | 951.5 (867.9-1052.0) | .90 |
| Med (IQR) range | 986.0-1384.0 | 665.0-1231.0 | 764.7-1399.0 | |
| Characterized length, μM | 3.03 (2.91-3.15) | 3.22 (2.94-3.36) | 3.26 (3.13-3.38) | .60 |
| Med (IQR) range | 2.73-3.24 | 2.77-3.63 | 2.80-3.62 | |
| Fiber thickness, μM | 1.90 (1.87-2.02) | 2.19 (1.0-2.37) | 2.08 (1.97-2.36) | .51 |
| Med (IQR) range | 1.72-2.27 | 1.89-2.82 | 1.38-2.59 | |
| Intersection density, ints/μM2 | 0.064 (0.058-0.071) | 0.054 (0.040-0.063) | 0.054 (0.049-0.060) | .93 |
| Med (IQR) range | 0.056-0.078 | 0.038-0.070 | 0.043-0.079 | |
ints, intersections; NA, not applicable.