Transplantation suitability based on patient-related risk factors
| Suitability . | Age, Karnofsky performance status, HCT-CI,∗ and MDS-specific FI† . |
|---|---|
| Fit patients | Age <80 y Karnofsky performance status score of ≥80% HCT-CI score of 0 to 2 (low or intermediate risk) MDS-specific FI of <0.3 |
| Patients who are unfit | Age ≥80 y Karnofsky performance status score of <80% HCT-CI score of ≥3 (high risk) MDS-specific FI of ≥0.3 |
| Suitability . | Age, Karnofsky performance status, HCT-CI,∗ and MDS-specific FI† . |
|---|---|
| Fit patients | Age <80 y Karnofsky performance status score of ≥80% HCT-CI score of 0 to 2 (low or intermediate risk) MDS-specific FI of <0.3 |
| Patients who are unfit | Age ≥80 y Karnofsky performance status score of <80% HCT-CI score of ≥3 (high risk) MDS-specific FI of ≥0.3 |
FI, frailty score; HCT-CI, HCT-specific comorbidity index.
HCT-CI scores identify 3 risk groups: 0 (low risk), 1 to 2 (intermediate risk), and ≥3 (high risk).64
MDS-specific FI takes into account 42 deficits measurements reflective of physical performance, comorbidities, laboratory values, instrumental activities of daily living, QoL, and performance status.66