Table 2.

The relationship between C3 levels and other variables

VariablesTotal (N = 381)High C3 (n = 110)Low C3 (n = 271)P value
Age, median (IQR), y 50 (33-62) 50.5 (36-62) 50 (32-60.5) .591 
Female, n (%) 203 (53) 50 (45) 153 (56) .066 
Follow-up time, median (IQR) 46 (16-556) 97 (19-589) 41 (14-539.5) .245 
Death, n (%) 194 (51) 39 (35) 155 (57) <.001∗∗∗ 
FIB, median (IQR), g/L 1.49 (1.14-2.82) 2.2 (1.36-3.83) 1.39 (1.06-2.42) <.001∗∗∗ 
C4, median (IQR), g/L 0.21 (0.13-0.29) 0.28 (0.21-0.33) 0.18 (0.11-0.25) <.001∗∗∗ 
WBC, median (IQR), ×109/L 3.26 (1.82-6.14) 3.81 (2.29-6.52) 3.04 (1.69-6.06) .034∗ 
ANC, median (IQR), ×109/L 2.03 (0.94-4.11) 2.6 (1.35-4.57) 1.76 (0.9-3.97) .022∗ 
PLT, median (IQR), ×109/L 53 (31-82) 65 (42.25-96) 47 (27-75) <.001∗∗∗ 
D-dimer, median (IQR), mg/L 3.52 (1.96-8.59) 2.57 (1.47-7.32) 4.14 (2.16-9.1) .002∗∗ 
PT, median (IQR), sec 15.1 (13.6-16.5) 14.25 (13.1-15.4) 15.4 (13.85-17) <.001∗∗∗ 
APTT, median (IQR), sec 41.8 (36.4-49.3) 39.8 (35.1-45.27) 42.7 (37.4-50.45) .001∗∗ 
Alb, median (IQR), g/L 29 (25.6-35) 30.8 (26.35-38.65) 28.3 (25.1-33.5) .013∗ 
AST, median (IQR), U/L 57 (30.1-165) 44.5 (29.75-109) 69 (30.15-191.5) .029∗ 
CRP, median (IQR), mg/L 32 (13.05-70.22) 50.3 (15.47-80.48) 28 (10.1-64.16) .016∗ 
CA153, median (IQR), U/mL 16.5 (10.8-25.8) 14.8 (8.67-21.9) 17.2 (11.4-27.6) .022∗ 
EBV DNA in PBMC, median (IQR), copies per mL, ×104 2.5 (0.28-98.4) 0.95 (0.22-9.98) 4.07 (0.32-134) .019∗ 
VariablesTotal (N = 381)High C3 (n = 110)Low C3 (n = 271)P value
Age, median (IQR), y 50 (33-62) 50.5 (36-62) 50 (32-60.5) .591 
Female, n (%) 203 (53) 50 (45) 153 (56) .066 
Follow-up time, median (IQR) 46 (16-556) 97 (19-589) 41 (14-539.5) .245 
Death, n (%) 194 (51) 39 (35) 155 (57) <.001∗∗∗ 
FIB, median (IQR), g/L 1.49 (1.14-2.82) 2.2 (1.36-3.83) 1.39 (1.06-2.42) <.001∗∗∗ 
C4, median (IQR), g/L 0.21 (0.13-0.29) 0.28 (0.21-0.33) 0.18 (0.11-0.25) <.001∗∗∗ 
WBC, median (IQR), ×109/L 3.26 (1.82-6.14) 3.81 (2.29-6.52) 3.04 (1.69-6.06) .034∗ 
ANC, median (IQR), ×109/L 2.03 (0.94-4.11) 2.6 (1.35-4.57) 1.76 (0.9-3.97) .022∗ 
PLT, median (IQR), ×109/L 53 (31-82) 65 (42.25-96) 47 (27-75) <.001∗∗∗ 
D-dimer, median (IQR), mg/L 3.52 (1.96-8.59) 2.57 (1.47-7.32) 4.14 (2.16-9.1) .002∗∗ 
PT, median (IQR), sec 15.1 (13.6-16.5) 14.25 (13.1-15.4) 15.4 (13.85-17) <.001∗∗∗ 
APTT, median (IQR), sec 41.8 (36.4-49.3) 39.8 (35.1-45.27) 42.7 (37.4-50.45) .001∗∗ 
Alb, median (IQR), g/L 29 (25.6-35) 30.8 (26.35-38.65) 28.3 (25.1-33.5) .013∗ 
AST, median (IQR), U/L 57 (30.1-165) 44.5 (29.75-109) 69 (30.15-191.5) .029∗ 
CRP, median (IQR), mg/L 32 (13.05-70.22) 50.3 (15.47-80.48) 28 (10.1-64.16) .016∗ 
CA153, median (IQR), U/mL 16.5 (10.8-25.8) 14.8 (8.67-21.9) 17.2 (11.4-27.6) .022∗ 
EBV DNA in PBMC, median (IQR), copies per mL, ×104 2.5 (0.28-98.4) 0.95 (0.22-9.98) 4.07 (0.32-134) .019∗ 

∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

CRP, C-reactive protein.

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