TCD results and brain MRI/MRA findings for treatment-naïve children with conditional TCD velocities who received hydroxyurea treatment
| . | Baseline . | Month 6 . | Month 12 . | Month 24 . | Month 36 . | Month 48 . | Month 60 . |
|---|---|---|---|---|---|---|---|
| TCD velocities | |||||||
| No. of children | 57 | 57 | 55 | 52 | 50 | 43 | 36 |
| No. of exams | 57 | 56 | 52 | 51 | 45 | 37 | 36 |
| Mean ± SD, cm/s | 180 ± 8 | 160 ± 18 | 157 ± 20 | 156 ± 22 | 151 ± 17 | 151 ± 19 | 153 ± 25 |
| Median (IQR), cm/s | 177 (173-185) | 160 (149- 174) | 157 (145- 169) | 159 (138- 174) | 151 (142- 164) | 147 (139- 165) | 153 (140-164) |
| Conditional velocities, n (%) | 57 (100) | 22 (39) | 12 (23) | 17 (33) | 4 (9) | 7 (19) | 6 (17) |
| Abnormal velocities, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (3) |
| Normal velocities, n (%) | 0 (0) | 34 (61) | 40 (77) | 34 (67) | 41 (91) | 30 (81) | 29 (81) |
| Brain MRI and MRA | |||||||
| No. of children | 57 | 52 | |||||
| No. of exams∗ | 48 | 41 | |||||
| MRI central review overall assessment, n (%) | |||||||
| Normal | 29 (60) | 23 (56) | |||||
| Abnormal | 19 (40) | 18 (44) | |||||
| Silent infarctions | 14 (29) | 12 (29) | |||||
| Vasculopathy | 12 (25) | 16 (39) | |||||
| . | Baseline . | Month 6 . | Month 12 . | Month 24 . | Month 36 . | Month 48 . | Month 60 . |
|---|---|---|---|---|---|---|---|
| TCD velocities | |||||||
| No. of children | 57 | 57 | 55 | 52 | 50 | 43 | 36 |
| No. of exams | 57 | 56 | 52 | 51 | 45 | 37 | 36 |
| Mean ± SD, cm/s | 180 ± 8 | 160 ± 18 | 157 ± 20 | 156 ± 22 | 151 ± 17 | 151 ± 19 | 153 ± 25 |
| Median (IQR), cm/s | 177 (173-185) | 160 (149- 174) | 157 (145- 169) | 159 (138- 174) | 151 (142- 164) | 147 (139- 165) | 153 (140-164) |
| Conditional velocities, n (%) | 57 (100) | 22 (39) | 12 (23) | 17 (33) | 4 (9) | 7 (19) | 6 (17) |
| Abnormal velocities, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (3) |
| Normal velocities, n (%) | 0 (0) | 34 (61) | 40 (77) | 34 (67) | 41 (91) | 30 (81) | 29 (81) |
| Brain MRI and MRA | |||||||
| No. of children | 57 | 52 | |||||
| No. of exams∗ | 48 | 41 | |||||
| MRI central review overall assessment, n (%) | |||||||
| Normal | 29 (60) | 23 (56) | |||||
| Abnormal | 19 (40) | 18 (44) | |||||
| Silent infarctions | 14 (29) | 12 (29) | |||||
| Vasculopathy | 12 (25) | 16 (39) | |||||
A total of 57 children not on treatment at initial TCD screening received hydroxyurea per protocol. Vasculopathy by MRA was scored based on any finding on either hemisphere.
IQR, interquartile range.
Month-24 exams paired to baseline exams.