EBV proteins on microarrays (microarray sequence, protein name, and EBV life cycle) for IgG and IgA Abs with evidence of differential levels between responders and nonresponders to EBVST immunotherapy, by time point
| Array sequence . | Protein name . | Life cycle . | t test P value . | FDR adj P value . | Responder group mean . | Nonresponder group mean . | IgG/ IgA . |
|---|---|---|---|---|---|---|---|
| Pre-EBVST immunotherapy | |||||||
| YP_001129440.1-20824-20955 | EBNA-LP | Latent | .03 | .998 | 1.04 | 1.29 | IgG |
| YP_001129483.1-112496-112035 | BGLF3.5 | Late lytic | .04 | .903 | 1.15 | 1.26 | IgA |
| 2 weeks after EBVST immunotherapy | |||||||
| YP_001129485.1-117754-118890 | BGRF1/BDRF1 | Late lytic | .01 | .998 | 0.97 | 1.01 | IgA |
| AFY97906.1-168167-168081 | LMP1 | Latent | .01 | .411 | 0.99 | 1.30 | IgG |
| YP_001129463.1-80447-82888 | EBNA3A | Latent | .02 | .998 | 1.23 | 1.36 | IgA |
| YP_001129483.1-112496-112035 | BGLF3.5 | Late lytic | .03 | .719 | 0.76 | 0.92 | IgG |
| AFY97929.1-67486-68700 | BMRF1 | Early lytic | .04 | .719 | 1.83 | 2.19 | IgG |
| YP_001129454.1-67745-68959 | BMRF1 | Early lytic | .05 | .719 | 1.97 | 2.30 | IgG |
| 4 weeks after EBVST immunotherapy | |||||||
| YP_001129449.1-59370-49906-3 | BPLF1 | Late lytic | .02 | .999 | 0.86 | 0.99 | IgA |
| 3 months after EBVST immunotherapy | |||||||
| YP_001129436.1-871-951 | LMP2A | Latent | <.01 | .058 | 1.10 | 1.39 | IgG |
| YP_001129455.1-68964-70037 | BMRF2 | Glycoprotein | <.01 | .058 | 1.14 | 1.38 | IgG |
| YP_001129436.1-360-458 | LMP2A | Latent | <.01 | .058 | 1.09 | 1.31 | IgG |
| YP_001129472.1-98500-98913 | BKRF2 | Glycoprotein | .01 | .058 | 0.92 | 1.18 | IgG |
| YP_001129436.1-540-788 | LMP2A | Latent | .01 | .058 | 0.94 | 1.15 | IgG |
| YP_001129484.1-113481-112483 | BGLF3 | Late lytic | .01 | .058 | 1.31 | 1.58 | IgG |
| YP_001129506.1-154125-153187 | BILF1 | Glycoprotein | .01 | .058 | 1.14 | 1.37 | IgG |
| YP_001129479.1-107679-108896 | BBRF3 | Glycoprotein | .01 | .058 | 1.53 | 1.97 | IgG |
| YP_401715.1-160908-158851 | BALF3 | Late lytic | .01 | .058 | 1.23 | 1.46 | IgG |
| CAA24827.1-122341-120929 | BGLF5 | Early lytic | .01 | .058 | 0.91 | 1.09 | IgG |
| YP_001129461.1-76771-77259 | BLRF2 | Late lytic | .01 | .058 | 2.18 | 2.61 | IgG |
| CAA24860.1-102116-101445 | BZLF2 | Glycoprotein | .01 | .058 | 1.95 | 2.43 | IgG |
| YP_001129485.1-117754-118890 | BGRF1/BDRF1 | Late lytic | .01 | .058 | 0.87 | 1.11 | IgG |
| YP_001129466.1-90630-89959 | BZLF2 | Glycoprotein | .01 | .058 | 2.02 | 2.47 | IgG |
| YP_001129500.1-136454-135636 | BVLF1 | Late lytic | .01 | .058 | 1.24 | 1.45 | IgG |
| YP_001129504.1-151808-150519 | LF2 | Early lytic | .02 | .058 | 1.14 | 1.38 | IgG |
| YP_001129436.1-1026-1196 | LMP2A | Latent | .02 | .058 | 1.05 | 1.24 | IgG |
| AFY97988.1-166888-166706 | BNLF2A | Late lytic | .02 | .058 | 1.17 | 1.36 | IgG |
| YP_001129440.1-35441-35473 | EBNA-LP | Latent | .02 | .058 | 0.83 | 1.09 | IgG |
| YP_001129470.1-94844-96457 | BRRF2 | Late lytic | .02 | .058 | 2.15 | 2.54 | IgG |
| YP_001129496.1-131574-129454 | BXLF2 | Glycoprotein | .02 | .058 | 1.35 | 1.54 | IgG |
| YP_001129498.1-133398-134144 | BXRF1 | Late lytic | .02 | .058 | 1.12 | 1.33 | IgG |
| YP_001129486.1-115415-114405 | BGLF2 | Early lytic | .02 | .058 | 1.16 | 1.39 | IgG |
| YP_001129439.1-9659-10171 | BcRF1 | Late lytic | .02 | .058 | 1.12 | 1.31 | IgG |
| YP_001129512.1-166530-167195 | BARF1 | Early lytic | .02 | .059 | 1.13 | 1.31 | IgG |
| CAA24838.1-61507-62037 | BFRF3 | Late lytic | .02 | .061 | 2.25 | 2.59 | IgG |
| YP_001129448.1-49335-49865 | BFRF3 | Late lytic | .03 | .078 | 2.37 | 2.70 | IgG |
| CAA24829.1-124938-125915 | BGRF1/BDRF1 | Late lytic | .03 | .078 | 0.92 | 1.15 | IgG |
| YP_001129488.1-117560-116883 | BDLF4 | Early lytic | .03 | .078 | 1.48 | 1.75 | IgG |
| YP_001129438.1-1736-5692-2 | FGAM | Other/unknown | .03 | .078 | 1.35 | 1.65 | IgG |
| AFY97924.1-49199-49729 | BFRF3 | Late lytic | .03 | .078 | 2.27 | 2.59 | IgG |
| YP_001129489.1-117772-117539 | BDLF3.5 | Glycoprotein | .03 | .078 | 0.91 | 1.11 | IgG |
| AFY97906.1-168167-168081 | LMP1 | Latent | .04 | .082 | 1.09 | 1.34 | IgG |
| YP_001129440.1-20824-20955 | EBNA-LP | Latent | .04 | .082 | 0.97 | 1.31 | IgG |
| YP_001129454.1-67745-68959 | BMRF1 | Early lytic | .04 | .082 | 1.98 | 2.36 | IgG |
| CAA24839.1-71527-62078-3 | BPLF1 | Late lytic | .05 | .093 | 0.76 | 0.96 | IgG |
| Array sequence . | Protein name . | Life cycle . | t test P value . | FDR adj P value . | Responder group mean . | Nonresponder group mean . | IgG/ IgA . |
|---|---|---|---|---|---|---|---|
| Pre-EBVST immunotherapy | |||||||
| YP_001129440.1-20824-20955 | EBNA-LP | Latent | .03 | .998 | 1.04 | 1.29 | IgG |
| YP_001129483.1-112496-112035 | BGLF3.5 | Late lytic | .04 | .903 | 1.15 | 1.26 | IgA |
| 2 weeks after EBVST immunotherapy | |||||||
| YP_001129485.1-117754-118890 | BGRF1/BDRF1 | Late lytic | .01 | .998 | 0.97 | 1.01 | IgA |
| AFY97906.1-168167-168081 | LMP1 | Latent | .01 | .411 | 0.99 | 1.30 | IgG |
| YP_001129463.1-80447-82888 | EBNA3A | Latent | .02 | .998 | 1.23 | 1.36 | IgA |
| YP_001129483.1-112496-112035 | BGLF3.5 | Late lytic | .03 | .719 | 0.76 | 0.92 | IgG |
| AFY97929.1-67486-68700 | BMRF1 | Early lytic | .04 | .719 | 1.83 | 2.19 | IgG |
| YP_001129454.1-67745-68959 | BMRF1 | Early lytic | .05 | .719 | 1.97 | 2.30 | IgG |
| 4 weeks after EBVST immunotherapy | |||||||
| YP_001129449.1-59370-49906-3 | BPLF1 | Late lytic | .02 | .999 | 0.86 | 0.99 | IgA |
| 3 months after EBVST immunotherapy | |||||||
| YP_001129436.1-871-951 | LMP2A | Latent | <.01 | .058 | 1.10 | 1.39 | IgG |
| YP_001129455.1-68964-70037 | BMRF2 | Glycoprotein | <.01 | .058 | 1.14 | 1.38 | IgG |
| YP_001129436.1-360-458 | LMP2A | Latent | <.01 | .058 | 1.09 | 1.31 | IgG |
| YP_001129472.1-98500-98913 | BKRF2 | Glycoprotein | .01 | .058 | 0.92 | 1.18 | IgG |
| YP_001129436.1-540-788 | LMP2A | Latent | .01 | .058 | 0.94 | 1.15 | IgG |
| YP_001129484.1-113481-112483 | BGLF3 | Late lytic | .01 | .058 | 1.31 | 1.58 | IgG |
| YP_001129506.1-154125-153187 | BILF1 | Glycoprotein | .01 | .058 | 1.14 | 1.37 | IgG |
| YP_001129479.1-107679-108896 | BBRF3 | Glycoprotein | .01 | .058 | 1.53 | 1.97 | IgG |
| YP_401715.1-160908-158851 | BALF3 | Late lytic | .01 | .058 | 1.23 | 1.46 | IgG |
| CAA24827.1-122341-120929 | BGLF5 | Early lytic | .01 | .058 | 0.91 | 1.09 | IgG |
| YP_001129461.1-76771-77259 | BLRF2 | Late lytic | .01 | .058 | 2.18 | 2.61 | IgG |
| CAA24860.1-102116-101445 | BZLF2 | Glycoprotein | .01 | .058 | 1.95 | 2.43 | IgG |
| YP_001129485.1-117754-118890 | BGRF1/BDRF1 | Late lytic | .01 | .058 | 0.87 | 1.11 | IgG |
| YP_001129466.1-90630-89959 | BZLF2 | Glycoprotein | .01 | .058 | 2.02 | 2.47 | IgG |
| YP_001129500.1-136454-135636 | BVLF1 | Late lytic | .01 | .058 | 1.24 | 1.45 | IgG |
| YP_001129504.1-151808-150519 | LF2 | Early lytic | .02 | .058 | 1.14 | 1.38 | IgG |
| YP_001129436.1-1026-1196 | LMP2A | Latent | .02 | .058 | 1.05 | 1.24 | IgG |
| AFY97988.1-166888-166706 | BNLF2A | Late lytic | .02 | .058 | 1.17 | 1.36 | IgG |
| YP_001129440.1-35441-35473 | EBNA-LP | Latent | .02 | .058 | 0.83 | 1.09 | IgG |
| YP_001129470.1-94844-96457 | BRRF2 | Late lytic | .02 | .058 | 2.15 | 2.54 | IgG |
| YP_001129496.1-131574-129454 | BXLF2 | Glycoprotein | .02 | .058 | 1.35 | 1.54 | IgG |
| YP_001129498.1-133398-134144 | BXRF1 | Late lytic | .02 | .058 | 1.12 | 1.33 | IgG |
| YP_001129486.1-115415-114405 | BGLF2 | Early lytic | .02 | .058 | 1.16 | 1.39 | IgG |
| YP_001129439.1-9659-10171 | BcRF1 | Late lytic | .02 | .058 | 1.12 | 1.31 | IgG |
| YP_001129512.1-166530-167195 | BARF1 | Early lytic | .02 | .059 | 1.13 | 1.31 | IgG |
| CAA24838.1-61507-62037 | BFRF3 | Late lytic | .02 | .061 | 2.25 | 2.59 | IgG |
| YP_001129448.1-49335-49865 | BFRF3 | Late lytic | .03 | .078 | 2.37 | 2.70 | IgG |
| CAA24829.1-124938-125915 | BGRF1/BDRF1 | Late lytic | .03 | .078 | 0.92 | 1.15 | IgG |
| YP_001129488.1-117560-116883 | BDLF4 | Early lytic | .03 | .078 | 1.48 | 1.75 | IgG |
| YP_001129438.1-1736-5692-2 | FGAM | Other/unknown | .03 | .078 | 1.35 | 1.65 | IgG |
| AFY97924.1-49199-49729 | BFRF3 | Late lytic | .03 | .078 | 2.27 | 2.59 | IgG |
| YP_001129489.1-117772-117539 | BDLF3.5 | Glycoprotein | .03 | .078 | 0.91 | 1.11 | IgG |
| AFY97906.1-168167-168081 | LMP1 | Latent | .04 | .082 | 1.09 | 1.34 | IgG |
| YP_001129440.1-20824-20955 | EBNA-LP | Latent | .04 | .082 | 0.97 | 1.31 | IgG |
| YP_001129454.1-67745-68959 | BMRF1 | Early lytic | .04 | .082 | 1.98 | 2.36 | IgG |
| CAA24839.1-71527-62078-3 | BPLF1 | Late lytic | .05 | .093 | 0.76 | 0.96 | IgG |
FDR correction method used was Benjamini and Hochberg. The table is ordered by t test P values (lowest to highest). t test P values < .05 are considered nominally significant for this analysis, with FDR-corrected values considered statistically significant.
adj, adjusted.