Emerging bispecific antibodies
Characteristic . | Epcoritamab21 . | Glofitamab20 . | Mosunetuzumab23 . | Odronextamab22 . |
---|---|---|---|---|
Overall cohort | ||||
Sample size | 157 | 155 | 129 | 49* |
ORR, % | 63 | 52 | 34.9 | 39* |
CR, % | 39 | 39 | 19.4 | 24* |
DOR, mo | 12 | 18.4 | 7.6 | 4.4* |
PFS, mo | 4.4 | 4.9 | 1.4 | 11.5 |
Follow-up, mo | 10.7 | 12.6 | 11.9 | 4.2 |
Post–CAR T-cell cohort | ||||
Sample size | 61 | 52 | 19 | 33 |
ORR, % | 54 | Not reported | 37 | 33 |
CR, % | 34 | 35 | 26 | 24 |
DOR (mos) | 9.7 | Not reported | Not reported | Not reached |
Characteristic . | Epcoritamab21 . | Glofitamab20 . | Mosunetuzumab23 . | Odronextamab22 . |
---|---|---|---|---|
Overall cohort | ||||
Sample size | 157 | 155 | 129 | 49* |
ORR, % | 63 | 52 | 34.9 | 39* |
CR, % | 39 | 39 | 19.4 | 24* |
DOR, mo | 12 | 18.4 | 7.6 | 4.4* |
PFS, mo | 4.4 | 4.9 | 1.4 | 11.5 |
Follow-up, mo | 10.7 | 12.6 | 11.9 | 4.2 |
Post–CAR T-cell cohort | ||||
Sample size | 61 | 52 | 19 | 33 |
ORR, % | 54 | Not reported | 37 | 33 |
CR, % | 34 | 35 | 26 | 24 |
DOR (mos) | 9.7 | Not reported | Not reported | Not reached |
Responses reported are for patients with DLBCL without prior CAR T-cell therapy.