Table 2.

Emerging bispecific antibodies

CharacteristicEpcoritamab21 Glofitamab20 Mosunetuzumab23 Odronextamab22 
Overall cohort     
 Sample size 157 155 129 49* 
 ORR, % 63 52 34.9 39* 
 CR, % 39 39 19.4 24* 
 DOR, mo 12 18.4 7.6 4.4* 
 PFS, mo 4.4 4.9 1.4 11.5 
 Follow-up, mo 10.7 12.6 11.9 4.2 
Post–CAR T-cell cohort     
 Sample size 61 52 19 33 
 ORR, % 54 Not reported 37 33 
 CR, % 34 35 26 24 
 DOR (mos) 9.7 Not reported Not reported Not reached 
CharacteristicEpcoritamab21 Glofitamab20 Mosunetuzumab23 Odronextamab22 
Overall cohort     
 Sample size 157 155 129 49* 
 ORR, % 63 52 34.9 39* 
 CR, % 39 39 19.4 24* 
 DOR, mo 12 18.4 7.6 4.4* 
 PFS, mo 4.4 4.9 1.4 11.5 
 Follow-up, mo 10.7 12.6 11.9 4.2 
Post–CAR T-cell cohort     
 Sample size 61 52 19 33 
 ORR, % 54 Not reported 37 33 
 CR, % 34 35 26 24 
 DOR (mos) 9.7 Not reported Not reported Not reached 
*

Responses reported are for patients with DLBCL without prior CAR T-cell therapy.

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