Demographic characteristics of ITP cohorts and controls
| Characteristic . | srITP . | cITP . | Unknown . |
|---|---|---|---|
| n = 209 . | n = 307 . | n = 75 . | |
| Sex | |||
| Female | 102 (49%) | 157 (51%) | 32 (43%) |
| Male | 107 (51%) | 150 (49%) | 43 (57%) |
| Ethnicity | |||
| Hispanic | 70 (34%) | 91 (30%) | 13 (17%) |
| Unknown ethnicity | 15 (7%) | 17 (6%) | 10 (13%) |
| Race | |||
| American Indian or Alaska Native | 1 (0.5%) | 1 (0.3%) | 1 (1.4%) |
| Asian | 4 (1.9%) | 13 (4.2%) | 1 (1.4%) |
| Black | 11 (5.3%) | 21 (6.8%) | 5 (6.9%) |
| Native Hawaiian or other Pacific Islander | 0 (0%) | 1 (0.3%) | 0 (0%) |
| White | 173 (82.8%) | 229 (74.6%) | 54 (75%) |
| Other | 5 (2.4%) | 18 (5.9%) | 2 (2.8%) |
| Unknown race | 15 (7.2%) | 24 (7.8%) | 9 (12.5%) |
| Age at diagnosis∗ (median, IQR) | 4.4 y (2.4-7.15) | 7.7 y (3.9-12.9) | 6.5 y (2.5-11.9) |
| Primary ITP | 183 (90%) | 219 (73%) | 68 (93%) |
| Secondary ITP† | |||
| Evans syndrome | 3 (2%) | 42 (14%) | 3 (4%) |
| Autoimmune lymphoproliferative syndrome | 0 (0%) | 5 (2%) | 1 (1%) |
| Autoimmune thyroid disease | 3 (1%) | 2 (1%) | 0 (0%) |
| Common variable immune deficiency, hypogammaglobulinemia | 1 (1%) | 20 (7%) | 0 (0%) |
| DiGeorge syndrome | 0 (0%) | 7 (2%) | 0 (0%) |
| Inflammatory bowel disease‡ | 1 (1%) | 3 (1%) | 0 (0%) |
| Immune disorder§ | 2 (1%) | 3 (1%) | 0 (0%) |
| Systemic lupus erythematosus/rheumatologic disease|| | 2 (1%) | 16 (5%) | 3 (4%) |
| Type 1 diabetes | 3 (1%) | 1 (0.3%) | 0 (0%) |
| Other¶ | 6 (3%) | 4 (1%) | 0 (0%) |
| Missing | 1 (1%) | 0 (0%) | 0 (0%) |
| Characteristic . | srITP . | cITP . | Unknown . |
|---|---|---|---|
| n = 209 . | n = 307 . | n = 75 . | |
| Sex | |||
| Female | 102 (49%) | 157 (51%) | 32 (43%) |
| Male | 107 (51%) | 150 (49%) | 43 (57%) |
| Ethnicity | |||
| Hispanic | 70 (34%) | 91 (30%) | 13 (17%) |
| Unknown ethnicity | 15 (7%) | 17 (6%) | 10 (13%) |
| Race | |||
| American Indian or Alaska Native | 1 (0.5%) | 1 (0.3%) | 1 (1.4%) |
| Asian | 4 (1.9%) | 13 (4.2%) | 1 (1.4%) |
| Black | 11 (5.3%) | 21 (6.8%) | 5 (6.9%) |
| Native Hawaiian or other Pacific Islander | 0 (0%) | 1 (0.3%) | 0 (0%) |
| White | 173 (82.8%) | 229 (74.6%) | 54 (75%) |
| Other | 5 (2.4%) | 18 (5.9%) | 2 (2.8%) |
| Unknown race | 15 (7.2%) | 24 (7.8%) | 9 (12.5%) |
| Age at diagnosis∗ (median, IQR) | 4.4 y (2.4-7.15) | 7.7 y (3.9-12.9) | 6.5 y (2.5-11.9) |
| Primary ITP | 183 (90%) | 219 (73%) | 68 (93%) |
| Secondary ITP† | |||
| Evans syndrome | 3 (2%) | 42 (14%) | 3 (4%) |
| Autoimmune lymphoproliferative syndrome | 0 (0%) | 5 (2%) | 1 (1%) |
| Autoimmune thyroid disease | 3 (1%) | 2 (1%) | 0 (0%) |
| Common variable immune deficiency, hypogammaglobulinemia | 1 (1%) | 20 (7%) | 0 (0%) |
| DiGeorge syndrome | 0 (0%) | 7 (2%) | 0 (0%) |
| Inflammatory bowel disease‡ | 1 (1%) | 3 (1%) | 0 (0%) |
| Immune disorder§ | 2 (1%) | 3 (1%) | 0 (0%) |
| Systemic lupus erythematosus/rheumatologic disease|| | 2 (1%) | 16 (5%) | 3 (4%) |
| Type 1 diabetes | 3 (1%) | 1 (0.3%) | 0 (0%) |
| Other¶ | 6 (3%) | 4 (1%) | 0 (0%) |
| Missing | 1 (1%) | 0 (0%) | 0 (0%) |
Table describes sex and race and ethnicity comparisons between srITP and cITP.
IQR, interquartile range; NOS, not otherwise specified.
Age of diagnosis missing for 15 srITP, 22 cITP, and 6 unknown patients with ITP.
Patients may have been diagnosed with >1 secondary cause of ITP.
Celiac disease, ulcerative colitis, and collagenous colitis.
Immune disorder NOS, Kabuki syndrome, Turner syndrome.
Sjögrens syndrome, juvenile inflammatory arthritis, mixed connective tissue disorder, lupus anticoagulant hypoprothrombinemia syndrome, and antiphospholipid antibody syndrome.
EBV infection, autoimmune hepatitis, psoriasis.