Table 1.

Summary of clinical trials for prevention approaches with low incidence of cGVHD

ApproachTrialNo.Age, yBM/PBSC, %MAC/RIC, %MRD/MUD/MMUD/haplo, %Other IS therapycGVHD incidence, %
ATG Kroger, 201621  83 39 (18-64) 0/100 100/0 100/0/0/0 CSA/MTX 32.2 (2 y) 
 Chang, 202019  132 48 (40-61) 4.5/95.5  100/0 100/0/0/0 CSA/MTX/MMF 27.9 (2 y) 
 Finke, 200920  103 40 (18-60) 20/80 100/0 0/80/20/0  CSA/MTX 30.8 (2 y) 
 Soiffer, 201722  126 46 (18-64) 18/75  100/0 0/100/0/0 TAC/MTX 16 (2 y) 
 Walker, 201623  99 49 (40-57) 11/89 67/33 0/84/16/0 CNI/MTX (or MMF)  26 (2 y) 
CD34 selection Devine, 201131  44 48.5 (21-59) 0/100 100/0 100/0/0/0 None 19 (2 y) 
 Luznik, 202239  114 51 (22-66) 6/94 100/0 38/62/0/0 None  8.9 (2 y) 
Naïve T-cell depletion Bleakley, 202232  138 37 (1-60) 0/100 100/0  61/39/0/0 TAC, TAC/MTX, TAC/MMF  7 (3 y) 
PTCy Bolanos-Meade, 201925  92 64 (56-72) 0/100 0/100 32/54/10/0 TAC/MMF 28 (1 y) 
 Bolanos-Meade, 202324  214 64.2  0/100 0/100 28/68/3/0 TAC/MMF 21.9 (1 y) 
 Shaw, 202329  80 51.5 (18-70) 100/0 50/50 0/0/100/0 SIR/MMF 20 RIC, 37.5 MAC (3 y) 
 Luznik, 202239  114 51 (20-66) 90/10 100/0 38/62/0/0 None 27 (2 y) 
 Luznik, 201026  117 50 (21-66) 100/0 100/0 67/33/0/0  None 10 (2 y) 
 Kanakry, 201430  92 49 (21-65) 100/0 100/0 49/51/0/0  None 14 (2 y) 
 Symons, 202040  96 42 (1-65) 100/0 100/0 0/0/0/100 TAC/MMF 15 (1 y) 
 Solomon, 201541  30 46 (24-60) 0/100 100/0 0/0/0/100 TAC/MMF 56 (18 mo) 
 Sanz, 202042  22 41 (18-55) 0/100 100/0 0/0/0/100 CSA/MMF 43 (2 y) 
 Sugita, 201943  50 36 (17-60) 0/100 100/0 0/0/0/100 TAC/MMF 36 (2 y) 
 Sugita, 201943  77 58 (22-65) 0/100 0/100 0/0/0/100 TAC/MMF 27 (2 y) 
 Al Malki, 202244  31 37 (21-58) 0/100 0/100 0/0/0/100 TAC/MMF 35 (2 y) 
 Fuchs, 202145  182 60 (20-70) 100/0 0/100 0/0/0/100 TAC/MMF 26 (2 y) 
ApproachTrialNo.Age, yBM/PBSC, %MAC/RIC, %MRD/MUD/MMUD/haplo, %Other IS therapycGVHD incidence, %
ATG Kroger, 201621  83 39 (18-64) 0/100 100/0 100/0/0/0 CSA/MTX 32.2 (2 y) 
 Chang, 202019  132 48 (40-61) 4.5/95.5  100/0 100/0/0/0 CSA/MTX/MMF 27.9 (2 y) 
 Finke, 200920  103 40 (18-60) 20/80 100/0 0/80/20/0  CSA/MTX 30.8 (2 y) 
 Soiffer, 201722  126 46 (18-64) 18/75  100/0 0/100/0/0 TAC/MTX 16 (2 y) 
 Walker, 201623  99 49 (40-57) 11/89 67/33 0/84/16/0 CNI/MTX (or MMF)  26 (2 y) 
CD34 selection Devine, 201131  44 48.5 (21-59) 0/100 100/0 100/0/0/0 None 19 (2 y) 
 Luznik, 202239  114 51 (22-66) 6/94 100/0 38/62/0/0 None  8.9 (2 y) 
Naïve T-cell depletion Bleakley, 202232  138 37 (1-60) 0/100 100/0  61/39/0/0 TAC, TAC/MTX, TAC/MMF  7 (3 y) 
PTCy Bolanos-Meade, 201925  92 64 (56-72) 0/100 0/100 32/54/10/0 TAC/MMF 28 (1 y) 
 Bolanos-Meade, 202324  214 64.2  0/100 0/100 28/68/3/0 TAC/MMF 21.9 (1 y) 
 Shaw, 202329  80 51.5 (18-70) 100/0 50/50 0/0/100/0 SIR/MMF 20 RIC, 37.5 MAC (3 y) 
 Luznik, 202239  114 51 (20-66) 90/10 100/0 38/62/0/0 None 27 (2 y) 
 Luznik, 201026  117 50 (21-66) 100/0 100/0 67/33/0/0  None 10 (2 y) 
 Kanakry, 201430  92 49 (21-65) 100/0 100/0 49/51/0/0  None 14 (2 y) 
 Symons, 202040  96 42 (1-65) 100/0 100/0 0/0/0/100 TAC/MMF 15 (1 y) 
 Solomon, 201541  30 46 (24-60) 0/100 100/0 0/0/0/100 TAC/MMF 56 (18 mo) 
 Sanz, 202042  22 41 (18-55) 0/100 100/0 0/0/0/100 CSA/MMF 43 (2 y) 
 Sugita, 201943  50 36 (17-60) 0/100 100/0 0/0/0/100 TAC/MMF 36 (2 y) 
 Sugita, 201943  77 58 (22-65) 0/100 0/100 0/0/0/100 TAC/MMF 27 (2 y) 
 Al Malki, 202244  31 37 (21-58) 0/100 0/100 0/0/0/100 TAC/MMF 35 (2 y) 
 Fuchs, 202145  182 60 (20-70) 100/0 0/100 0/0/0/100 TAC/MMF 26 (2 y) 

CSA, cyclosporine; MAC, myeloablative conditioning; MRD, matched related donor; MUD, matched unrelated donor; MMUD, mismatched unrelated donor; RIC, reduced-intensity conditioning.

Chang 202019: PBSC included PBSC N = 76 (57.6%) as well as bone marrow transplant (BMT) + PBSC N = 50 (37.9%). Finke 200920: N = 21 (20%) had human leukocyte antigen (HLA)-C mismatch. Soiffer 201722: N = 9 (7%) unknown graft source. Walker 2016: included CNI (either CSA or TAC) combined with MTX or MMF. Luznik 202239: reported approach/IS therapy per randomly assigned therapy, whereas N = 15 in the CD34 selection arm of the trial received TAC/MTX or other as treatment noncompliance, and N = 9 in the PTCy arm received noncompliant therapy of TAC/MTX or other. Bleakley 202232: had all myeloablative regimens, but 72% high intensity and 28% intermediate intensity; the combined report summarized different trials, which varied in the delivered pharmacologic immune suppression (included TAC alone, TAC/MTX, or TAC/MMF) alongside the naïve T-cell depletion approach. Bolanos-Meade25 2023: age reported as mean (64.2 years, ±8.5 years). Luznik 201026: 1 related donor was an HLA-identical parent. Kanakry 201430: 1 patient had a 10/10 HLA matched familial donor (grouped here with the matched sibling donor group).

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