Multivariable logistic analysis for induction death
| . | Multivariable logistic for achieving CR . | ||||
|---|---|---|---|---|---|
| OR . | 95% CI . | P value . | |||
| Age, y | ≥40 vs <40 | 0.37 | 0.21 | 0.64 | .0004 |
| ECOG PS score | 2 vs 0-1 | 0.81 | 0.41 | 1.59 | .53 |
| 3 vs 0-1 | 0.14 | 0.07 | 0.29 | <.0001 | |
| Morphology | M3v vs M3 | 0.76 | 0.34 | 1.70 | .51 |
| Relapse risk | High vs low/Int | 0.35 | 0.20 | 0.62 | .0003 |
| PML/RARA breakpoint | bcr3 vs bcr1/2 | 0.44 | 0.25 | 0.77 | .004 |
| Time from symptom to DX | 48-72 vs <48 h | 0.20 | 0.08 | 0.53 | .0011 |
| ≥4 d vs <48 h | 0.30 | 0.12 | 0.78 | .01 | |
| CNS bleeding | Yes vs no | 0.09 | 0.04 | 0.19 | <.0001 |
| Pulmonary hemorrhage | Yes vs no | 0.14 | 0.05 | 0.42 | .0004 |
| . | Multivariable logistic for achieving CR . | ||||
|---|---|---|---|---|---|
| OR . | 95% CI . | P value . | |||
| Age, y | ≥40 vs <40 | 0.37 | 0.21 | 0.64 | .0004 |
| ECOG PS score | 2 vs 0-1 | 0.81 | 0.41 | 1.59 | .53 |
| 3 vs 0-1 | 0.14 | 0.07 | 0.29 | <.0001 | |
| Morphology | M3v vs M3 | 0.76 | 0.34 | 1.70 | .51 |
| Relapse risk | High vs low/Int | 0.35 | 0.20 | 0.62 | .0003 |
| PML/RARA breakpoint | bcr3 vs bcr1/2 | 0.44 | 0.25 | 0.77 | .004 |
| Time from symptom to DX | 48-72 vs <48 h | 0.20 | 0.08 | 0.53 | .0011 |
| ≥4 d vs <48 h | 0.30 | 0.12 | 0.78 | .01 | |
| CNS bleeding | Yes vs no | 0.09 | 0.04 | 0.19 | <.0001 |
| Pulmonary hemorrhage | Yes vs no | 0.14 | 0.05 | 0.42 | .0004 |
Data are stratified by country; because of small sample size, Uruguay and Paraguay were combined before stratification.
Only variables with P < .1 from univariable analysis are included in this multivariable analysis; laboratory values with a large amount of missing data were not considered in the model.
DX, diagnosis; Int, intermediate; M3, classic morphology subtype; M3v, variant morphology subtype; PS, performance status.