Comparison of patient status, clinical features, genetics, and genomics in BTK-WT and BTK-mutant cohorts
| Clinical feature . | n (%) or median (range) . | P value . | |
|---|---|---|---|
| BTK-WT; n = 7 . | BTK-mutant, n = 11 . | ||
| Age, y | 71 (59-82) | 75 (54-87) | .429 |
| ECOG status | |||
| 0 | 4 (57) | 5 (46) | .581 |
| 1 | 3 (43) | 5 (46) | |
| 2 | 1 (8) | ||
| Immunoglobulin (Ig), mg/dL | |||
| IgA | 92 (17-240) | 54 (2-117) | .091 |
| IgG | 748 (440-1161) | 565 (147-1026) | .061 |
| IgM | 28 (10-81) | 27 (10-225) | .187 |
| % lymphocyte | 85 (26-96) | 71 (50-97) | .394 |
| Platelets, ×103/uL | 148 (35-230) | 59 (17-184) | .021 |
| % neutrophils | 13 (3-64) | 20 (0-43) | .469 |
| Hemoglobin, g/dL | 12.1 (10.5-14.5) | 10.7 (7.1-14.5) | .195 |
| B2M, mg/L | 3.80 (2.60-4.45) | 4.40 (2.2-6.20) | .034 |
| Cytogenetics by FISH | |||
| Del(17p) | 2 (29) | 2 (18) | 1 |
| Del(11q) | 2 (29) | 3 (27) | |
| Trisomy 12 | 1 (14) | 2 (18) | |
| None | 1 (14) | 2 (18) | |
| Del(13q) | 5 (71) | 6 (55) | |
| IGHV status | |||
| Unmutated | 6 (86) | 9 (75) | .846 |
| Mutated | 1 (14) | 1 (8) + 1 (8) undetermined | |
| Clinical feature . | n (%) or median (range) . | P value . | |
|---|---|---|---|
| BTK-WT; n = 7 . | BTK-mutant, n = 11 . | ||
| Age, y | 71 (59-82) | 75 (54-87) | .429 |
| ECOG status | |||
| 0 | 4 (57) | 5 (46) | .581 |
| 1 | 3 (43) | 5 (46) | |
| 2 | 1 (8) | ||
| Immunoglobulin (Ig), mg/dL | |||
| IgA | 92 (17-240) | 54 (2-117) | .091 |
| IgG | 748 (440-1161) | 565 (147-1026) | .061 |
| IgM | 28 (10-81) | 27 (10-225) | .187 |
| % lymphocyte | 85 (26-96) | 71 (50-97) | .394 |
| Platelets, ×103/uL | 148 (35-230) | 59 (17-184) | .021 |
| % neutrophils | 13 (3-64) | 20 (0-43) | .469 |
| Hemoglobin, g/dL | 12.1 (10.5-14.5) | 10.7 (7.1-14.5) | .195 |
| B2M, mg/L | 3.80 (2.60-4.45) | 4.40 (2.2-6.20) | .034 |
| Cytogenetics by FISH | |||
| Del(17p) | 2 (29) | 2 (18) | 1 |
| Del(11q) | 2 (29) | 3 (27) | |
| Trisomy 12 | 1 (14) | 2 (18) | |
| None | 1 (14) | 2 (18) | |
| Del(13q) | 5 (71) | 6 (55) | |
| IGHV status | |||
| Unmutated | 6 (86) | 9 (75) | .846 |
| Mutated | 1 (14) | 1 (8) + 1 (8) undetermined | |
FISH, fluorescence in situ hybridization