OR and 95% CI of patient characteristics associated with 30-day mortality after initial SACT
| . | Unadjusted OR (95% CI) (n = 7903∗) . | aOR† (95% CI) (n = 7903∗) . |
|---|---|---|
| Intensity of SACT | ||
| IT | 1 [reference] | 1 [reference] |
| NIT | 1.82 (1.56-2.13) | 0.74 (0.60-0.92) |
| IU | 1.94 (1.50-2.53) | 0.92 (0.68-1.25) |
| Age at diagnosis, y | ||
| 18-54 | 1 [reference] | 1 [reference] |
| 55-64 | 1.49 (1.12-1.98) | 1.41 (1.05-1.88) |
| 65-74 | 2.71 (2.14-3.44) | 2.47 (1.92-3.20) |
| 75-84 | 3.43 (2.67-4.39) | 2.91 (2.14-3.95) |
| 85-99 | 7.21 (5.10-10.19) | 4.99 (3.32-7.51) |
| Sex | ||
| Female | 1 [reference] | 1 [reference] |
| Male | 1.03 (0.89-1.20) | 0.98 (0.84-1.15) |
| Ethnicity | ||
| White | 1 [reference] | 1 [reference] |
| Asian | 0.71 (0.45-1.11) | 0.93 (0.58-1.50) |
| Black | 0.57 (0.30-1.08) | 0.72 (0.37-1.41) |
| Mixed/other | 0.60 (0.35-1.01) | 0.81 (0.47-1.41) |
| Unknown | 1.81 (1.29-2.54) | 2.00 (1.40-2.85) |
| IMD quintile | ||
| 1 (least deprived) | 1 [reference] | 1 [reference] |
| 2 | 1.20 (0.96-1.49) | 1.19 (0.94-1.50) |
| 3 | 1.11 (0.88-1.39) | 1.11 (0.87-1.41) |
| 4 | 0.95 (0.75-1.21) | 1.00 (0.77-1.28) |
| 5 (most deprived) | 1.15 (0.90-1.46) | 1.22 (0.94-1.57) |
| Comorbidity (total Charlson score) | ||
| 0 | 1 [reference] | 1 [reference] |
| 1 | 1.20 (0.92-1.55) | 0.99 (0.75-1.31) |
| 2 | 1.54 (1.13-2.09) | 1.21 (0.87-1.69) |
| ≥3 | 2.41 (1.80-3.23) | 1.58 (1.15-2.18) |
| Year of diagnosis | ||
| 2013 | 0.91 (0.66-1.26) | 0.78 (0.56-1.11) |
| 2014 | 0.78 (0.57-1.07) | 0.75 (0.54-1.05) |
| 2015 | 0.85 (0.63-1.14) | 0.91 (0.66-1.24) |
| 2016 | 0.96 (0.72-1.28) | 0.97 (0.71-1.31) |
| 2017 | 1 [reference] | 1 [reference] |
| 2018 | 1.01 (0.76-1.33) | 1.04 (0.78-1.39) |
| 2019 | 0.97 (0.74-1.29) | 1.01 (0.75-1.34) |
| 2020 | 1.09 (0.84-1.43) | 1.12 (0.84-1.49) |
| ECOG PS score | ||
| 0 | 1 [reference] | 1 [reference] |
| 1 | 1.64 (1.30-2.07) | 1.34 (1.05-1.71) |
| 2 | 4.61 (3.51-6.06) | 3.36 (2.52-4.47) |
| 3/4 | 12.46 (8.96-17.33) | 9.46 (6.69-13.36) |
| Unknown | 1.98 (1.60-2.46) | 1.53 (1.22-1.94) |
| BMI | ||
| Underweight (<18.5 kg/m2) | 1.04 (0.56-1.91) | 0.91 (0.48-1.73) |
| Normal weight (18.5 to <25.0 kg/m2) | 1 [reference] | 1 [reference] |
| Overweight (25.0 to <30.0 kg/m2) | 1.10 (0.89-1.37) | 1.06 (0.84-1.32) |
| Obese (≥30.0 kg/m2) | 1.21 (0.97-1.52) | 1.12 (0.89-1.42) |
| Unknown | 2.71 (2.20-3.35) | 2.17 (1.71-2.75) |
| . | Unadjusted OR (95% CI) (n = 7903∗) . | aOR† (95% CI) (n = 7903∗) . |
|---|---|---|
| Intensity of SACT | ||
| IT | 1 [reference] | 1 [reference] |
| NIT | 1.82 (1.56-2.13) | 0.74 (0.60-0.92) |
| IU | 1.94 (1.50-2.53) | 0.92 (0.68-1.25) |
| Age at diagnosis, y | ||
| 18-54 | 1 [reference] | 1 [reference] |
| 55-64 | 1.49 (1.12-1.98) | 1.41 (1.05-1.88) |
| 65-74 | 2.71 (2.14-3.44) | 2.47 (1.92-3.20) |
| 75-84 | 3.43 (2.67-4.39) | 2.91 (2.14-3.95) |
| 85-99 | 7.21 (5.10-10.19) | 4.99 (3.32-7.51) |
| Sex | ||
| Female | 1 [reference] | 1 [reference] |
| Male | 1.03 (0.89-1.20) | 0.98 (0.84-1.15) |
| Ethnicity | ||
| White | 1 [reference] | 1 [reference] |
| Asian | 0.71 (0.45-1.11) | 0.93 (0.58-1.50) |
| Black | 0.57 (0.30-1.08) | 0.72 (0.37-1.41) |
| Mixed/other | 0.60 (0.35-1.01) | 0.81 (0.47-1.41) |
| Unknown | 1.81 (1.29-2.54) | 2.00 (1.40-2.85) |
| IMD quintile | ||
| 1 (least deprived) | 1 [reference] | 1 [reference] |
| 2 | 1.20 (0.96-1.49) | 1.19 (0.94-1.50) |
| 3 | 1.11 (0.88-1.39) | 1.11 (0.87-1.41) |
| 4 | 0.95 (0.75-1.21) | 1.00 (0.77-1.28) |
| 5 (most deprived) | 1.15 (0.90-1.46) | 1.22 (0.94-1.57) |
| Comorbidity (total Charlson score) | ||
| 0 | 1 [reference] | 1 [reference] |
| 1 | 1.20 (0.92-1.55) | 0.99 (0.75-1.31) |
| 2 | 1.54 (1.13-2.09) | 1.21 (0.87-1.69) |
| ≥3 | 2.41 (1.80-3.23) | 1.58 (1.15-2.18) |
| Year of diagnosis | ||
| 2013 | 0.91 (0.66-1.26) | 0.78 (0.56-1.11) |
| 2014 | 0.78 (0.57-1.07) | 0.75 (0.54-1.05) |
| 2015 | 0.85 (0.63-1.14) | 0.91 (0.66-1.24) |
| 2016 | 0.96 (0.72-1.28) | 0.97 (0.71-1.31) |
| 2017 | 1 [reference] | 1 [reference] |
| 2018 | 1.01 (0.76-1.33) | 1.04 (0.78-1.39) |
| 2019 | 0.97 (0.74-1.29) | 1.01 (0.75-1.34) |
| 2020 | 1.09 (0.84-1.43) | 1.12 (0.84-1.49) |
| ECOG PS score | ||
| 0 | 1 [reference] | 1 [reference] |
| 1 | 1.64 (1.30-2.07) | 1.34 (1.05-1.71) |
| 2 | 4.61 (3.51-6.06) | 3.36 (2.52-4.47) |
| 3/4 | 12.46 (8.96-17.33) | 9.46 (6.69-13.36) |
| Unknown | 1.98 (1.60-2.46) | 1.53 (1.22-1.94) |
| BMI | ||
| Underweight (<18.5 kg/m2) | 1.04 (0.56-1.91) | 0.91 (0.48-1.73) |
| Normal weight (18.5 to <25.0 kg/m2) | 1 [reference] | 1 [reference] |
| Overweight (25.0 to <30.0 kg/m2) | 1.10 (0.89-1.37) | 1.06 (0.84-1.32) |
| Obese (≥30.0 kg/m2) | 1.21 (0.97-1.52) | 1.12 (0.89-1.42) |
| Unknown | 2.71 (2.20-3.35) | 2.17 (1.71-2.75) |
30-day mortality-related analyses were based on 7903 patients of the total 7906 documented as receiving SACT treatment. Three patients (2 had death certificate only vital status data and 1 uncertain date of death) were excluded.
Adjusted for intensity of SACT, age at diagnosis, sex, ethnicity, deprivation, comorbidity, year of diagnosis, PS, and BMI. The multivariate model had an area under receiver operating characteristic of 0.72 for predicting 30-day mortality.