HR and 95% CI of patient characteristics associated with 1- and 5-year OS
| . | 1-y OS (n = 16 773∗) . | 5-y OS (n = 16 773∗) . | ||
|---|---|---|---|---|
| Unadjusted HR (95% CI) . | aHR† (95% CI) . | Unadjusted HR (95% CI) . | aHR† (95% CI) . | |
| Intensity of SACT | ||||
| IT | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| NIT | 2.23 (2.08-2.39) | 1.10 (1.01-1.18) | 2.27 (2.15-2.41) | 1.13 (1.06-1.20) |
| IU | 2.08 (1.84-2.34) | 1.31 (1.16-1.49) | 1.87 (1.69-2.07) | 1.26 (1.14-1.39) |
| No documented SACT | 4.07 (3.85-4.30) | 2.26 (2.12-2.40) | 3.19 (3.05-3.33) | 1.89 (1.80-1.99) |
| Age at diagnosis, y | ||||
| 18-54 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 55-64 | 1.74 (1.58-1.91) | 1.65 (1.50-1.82) | 1.75 (1.63-1.88) | 1.68 (1.56-1.81) |
| 65-74 | 3.04 (2.80-3.30) | 2.71 (2.49-2.95) | 3.11 (2.92-3.31) | 2.83 (2.66-3.02) |
| 75-84 | 5.49 (5.07-5.94) | 4.11 (3.77-4.48) | 5.39 (5.06-5.73) | 4.29 (4.01-4.60) |
| 85-99 | 9.48 (8.71-10.32) | 5.96 (5.44-6.53) | 9.17 (8.55-9.84) | 6.35 (5.89-6.85) |
| Sex | ||||
| Female | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| Male | 1.00 (0.96-1.04) | 0.98 (0.94-1.02) | 1.05 (1.01-1.09) | 1.02 (0.98-1.05) |
| Ethnicity | ||||
| White | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| Asian | 0.64 (0.56-0.72) | 0.86 (0.76-0.98) | 0.63 (0.56-0.70) | 0.86 (0.77-0.96) |
| Black | 0.63 (0.54-0.75) | 0.83 (0.70-0.98) | 0.68 (0.59-0.78) | 0.84 (0.73-0.96) |
| Mixed/other | 0.55 (0.47-0.65) | 0.93 (0.79-1.10) | 0.60 (0.53-0.69) | 0.98 (0.86-1.11) |
| Unknown | 1.35 (1.23-1.48) | 1.37 (1.25-1.51) | 1.27 (1.16-1.38) | 1.32 (1.21-1.44) |
| IMD quintile | ||||
| 1 (least deprived) | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 2 | 1.04 (0.98-1.10) | 1.08 (1.02-1.14) | 1.03 (0.98-1.08) | 1.07 (1.01-1.12) |
| 3 | 1.04 (0.98-1.11) | 1.10 (1.03-1.16) | 1.04 (0.98-1.09) | 1.10 (1.04-1.16) |
| 4 | 1.01 (0.95-1.07) | 1.10 (1.04-1.17) | 1.00 (0.95-1.05) | 1.10 (1.04-1.16) |
| 5 (most deprived) | 0.99 (0.93-1.06) | 1.18 (1.11-1.26) | 0.98 (0.92-1.03) | 1.17 (1.11-1.24) |
| Comorbidity (total Charlson score) | ||||
| 0 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 1 | 1.57 (1.47-1.66) | 1.20 (1.13-1.28) | 1.57 (1.49-1.66) | 1.21 (1.15-1.28) |
| 2 | 1.79 (1.67-1.93) | 1.30 (1.21-1.39) | 1.73 (1.63-1.85) | 1.27 (1.19-1.35) |
| ≥3 | 2.29 (2.14-2.45) | 1.45 (1.35-1.55) | 2.25 (2.12-2.40) | 1.44 (1.35-1.54) |
| Year of diagnosis | ||||
| 2013 | 1.04 (0.97-1.13) | 0.91 (0.84-0.98) | 1.05 (0.98-1.12) | 0.95 (0.89-1.02) |
| 2014 | 1.01 (0.93-1.09) | 0.94 (0.87-1.01) | 1.00 (0.94-1.07) | 0.96 (0.90-1.03) |
| 2015 | 1.00 (0.92-1.08) | 0.96 (0.89-1.04) | 1.00 (0.93-1.07) | 0.98 (0.92-1.05) |
| 2016 | 1.04 (0.96-1.12) | 0.97 (0.90-1.05) | 1.04 (0.97-1.11) | 0.99 (0.93-1.06) |
| 2017 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 2018 | 1.04 (0.96-1.12) | 1.06 (0.98-1.14) | 1.02 (0.95-1.09) | 1.03 (0.97-1.11) |
| 2019 | 1.02 (0.94-1.10) | 1.04 (0.96-1.13) | 1.01 (0.95-1.08) | 1.04 (0.97-1.11) |
| 2020 | 1.04 (0.96-1.13) | 1.10 (1.02-1.20) | 1.00 (0.93-1.07) | 1.05 (0.98-1.13) |
| . | 1-y OS (n = 16 773∗) . | 5-y OS (n = 16 773∗) . | ||
|---|---|---|---|---|
| Unadjusted HR (95% CI) . | aHR† (95% CI) . | Unadjusted HR (95% CI) . | aHR† (95% CI) . | |
| Intensity of SACT | ||||
| IT | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| NIT | 2.23 (2.08-2.39) | 1.10 (1.01-1.18) | 2.27 (2.15-2.41) | 1.13 (1.06-1.20) |
| IU | 2.08 (1.84-2.34) | 1.31 (1.16-1.49) | 1.87 (1.69-2.07) | 1.26 (1.14-1.39) |
| No documented SACT | 4.07 (3.85-4.30) | 2.26 (2.12-2.40) | 3.19 (3.05-3.33) | 1.89 (1.80-1.99) |
| Age at diagnosis, y | ||||
| 18-54 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 55-64 | 1.74 (1.58-1.91) | 1.65 (1.50-1.82) | 1.75 (1.63-1.88) | 1.68 (1.56-1.81) |
| 65-74 | 3.04 (2.80-3.30) | 2.71 (2.49-2.95) | 3.11 (2.92-3.31) | 2.83 (2.66-3.02) |
| 75-84 | 5.49 (5.07-5.94) | 4.11 (3.77-4.48) | 5.39 (5.06-5.73) | 4.29 (4.01-4.60) |
| 85-99 | 9.48 (8.71-10.32) | 5.96 (5.44-6.53) | 9.17 (8.55-9.84) | 6.35 (5.89-6.85) |
| Sex | ||||
| Female | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| Male | 1.00 (0.96-1.04) | 0.98 (0.94-1.02) | 1.05 (1.01-1.09) | 1.02 (0.98-1.05) |
| Ethnicity | ||||
| White | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| Asian | 0.64 (0.56-0.72) | 0.86 (0.76-0.98) | 0.63 (0.56-0.70) | 0.86 (0.77-0.96) |
| Black | 0.63 (0.54-0.75) | 0.83 (0.70-0.98) | 0.68 (0.59-0.78) | 0.84 (0.73-0.96) |
| Mixed/other | 0.55 (0.47-0.65) | 0.93 (0.79-1.10) | 0.60 (0.53-0.69) | 0.98 (0.86-1.11) |
| Unknown | 1.35 (1.23-1.48) | 1.37 (1.25-1.51) | 1.27 (1.16-1.38) | 1.32 (1.21-1.44) |
| IMD quintile | ||||
| 1 (least deprived) | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 2 | 1.04 (0.98-1.10) | 1.08 (1.02-1.14) | 1.03 (0.98-1.08) | 1.07 (1.01-1.12) |
| 3 | 1.04 (0.98-1.11) | 1.10 (1.03-1.16) | 1.04 (0.98-1.09) | 1.10 (1.04-1.16) |
| 4 | 1.01 (0.95-1.07) | 1.10 (1.04-1.17) | 1.00 (0.95-1.05) | 1.10 (1.04-1.16) |
| 5 (most deprived) | 0.99 (0.93-1.06) | 1.18 (1.11-1.26) | 0.98 (0.92-1.03) | 1.17 (1.11-1.24) |
| Comorbidity (total Charlson score) | ||||
| 0 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 1 | 1.57 (1.47-1.66) | 1.20 (1.13-1.28) | 1.57 (1.49-1.66) | 1.21 (1.15-1.28) |
| 2 | 1.79 (1.67-1.93) | 1.30 (1.21-1.39) | 1.73 (1.63-1.85) | 1.27 (1.19-1.35) |
| ≥3 | 2.29 (2.14-2.45) | 1.45 (1.35-1.55) | 2.25 (2.12-2.40) | 1.44 (1.35-1.54) |
| Year of diagnosis | ||||
| 2013 | 1.04 (0.97-1.13) | 0.91 (0.84-0.98) | 1.05 (0.98-1.12) | 0.95 (0.89-1.02) |
| 2014 | 1.01 (0.93-1.09) | 0.94 (0.87-1.01) | 1.00 (0.94-1.07) | 0.96 (0.90-1.03) |
| 2015 | 1.00 (0.92-1.08) | 0.96 (0.89-1.04) | 1.00 (0.93-1.07) | 0.98 (0.92-1.05) |
| 2016 | 1.04 (0.96-1.12) | 0.97 (0.90-1.05) | 1.04 (0.97-1.11) | 0.99 (0.93-1.06) |
| 2017 | 1 [reference] | 1 [reference] | 1 [reference] | 1 [reference] |
| 2018 | 1.04 (0.96-1.12) | 1.06 (0.98-1.14) | 1.02 (0.95-1.09) | 1.03 (0.97-1.11) |
| 2019 | 1.02 (0.94-1.10) | 1.04 (0.96-1.13) | 1.01 (0.95-1.08) | 1.04 (0.97-1.11) |
| 2020 | 1.04 (0.96-1.13) | 1.10 (1.02-1.20) | 1.00 (0.93-1.07) | 1.05 (0.98-1.13) |
Survival-related analyses were based on 16 773 patients of the total cohort of 17 107; 334 patients were excluded from survival analyses, of whom 331 had death certificate only data and 3 had an uncertain date of death.
Adjusted for intensity of SACT, age at diagnosis, sex, ethnicity, deprivation, comorbidity, and year of diagnosis.