Table 2.

GVHD organ involvement categories in the training cohort

Organ involvementFirst 24 categoriesCollapsed 14 categoriesDay 28 ORR (%)GlucksbergMinnesota riskCARTK-means
n6-mo NRM (%)n6-mo NRM (%)Manhattan riskManhattan risk
Isolated stage I skin 135 5.3 135 5.3 63.0 Grade 1 Standard Low Low 
Isolated stage II skin 259 7.8 259 7.8 76.1 Grade 1 Standard Low Low 
Isolated UGI 112 8.1 112 8.1 73.2 Grade 2 Standard Low Low 
Stage I skin + UGI 35 5.7 35 5.7 77.1 Grade 2 Standard Low Low 
Stage II skin + UGI 33 21.2 33 21.2 81.8 Grade 2 Standard Intermediate Intermediate 
Stage I LGI ± UGI 151 14.0 151 14.0 66.2 Grade 2 Standard Intermediate Intermediate 
Stage I skin + stage I LGI ± UGI 47 14.9 83 14.6 71.1 Grade 2 Standard Intermediate Intermediate 
Stage II skin + stage I LGI ± UGI 20 14.8    Grade 2    
Stage III skin + stage I LGI ± UGI 16 12.5    Grade 2    
Stage III skin ± UGI 222 11.8 222 11.8 72.5 Grade 2 Standard Intermediate Intermediate 
Stage II LGI ± UGI 63 15.9 63 15.9 58.7 Grade 3 Standard Intermediate Intermediate 
Stage I liver ± other organ involvement 20 35.5 59 46.6 40.7 Grade 2-4 Standard/High High High 
Stage II liver ± other organ involvement 23 37.8    Grade 3-4 Standard/High High High 
Stage III liver ± other organ involvement 12 73.1    Grade 3-4 Standard/High High High 
Stage IV liver ± other organ involvement 4 75.0    Grade 4 Standard/High High High 
Stage I skin + stage II LGI ± UGI 15 26.7 34 29.4 64.7 Grade 3 High High High 
Stage II skin + stage II LGI ± UGI 10 40.0    Grade 3    
Stage III skin + stage II LGI ± UGI 9 22.2    Grade 3    
Stage III LGI ± UGI 53 34.3 53 34.3 43.4 Grade 3 High High High 
Stage I skin + stage III LGI ± UGI 9 33.3 21 49.1 52.4 Grade 3 High High High 
Stage II skin + stage III LGI ± UGI 7 65.7    Grade 3    
Stage III skin + stage III LGI ± UGI 5 60.0    Grade 3    
Stage IV skin ± LGI ± UGI 8 25.0 46 32.6 47.8 Grade 4 High High High 
Stage IV LGI ± skin ± UGI 38 34.2    Grade 3    
Organ involvementFirst 24 categoriesCollapsed 14 categoriesDay 28 ORR (%)GlucksbergMinnesota riskCARTK-means
n6-mo NRM (%)n6-mo NRM (%)Manhattan riskManhattan risk
Isolated stage I skin 135 5.3 135 5.3 63.0 Grade 1 Standard Low Low 
Isolated stage II skin 259 7.8 259 7.8 76.1 Grade 1 Standard Low Low 
Isolated UGI 112 8.1 112 8.1 73.2 Grade 2 Standard Low Low 
Stage I skin + UGI 35 5.7 35 5.7 77.1 Grade 2 Standard Low Low 
Stage II skin + UGI 33 21.2 33 21.2 81.8 Grade 2 Standard Intermediate Intermediate 
Stage I LGI ± UGI 151 14.0 151 14.0 66.2 Grade 2 Standard Intermediate Intermediate 
Stage I skin + stage I LGI ± UGI 47 14.9 83 14.6 71.1 Grade 2 Standard Intermediate Intermediate 
Stage II skin + stage I LGI ± UGI 20 14.8    Grade 2    
Stage III skin + stage I LGI ± UGI 16 12.5    Grade 2    
Stage III skin ± UGI 222 11.8 222 11.8 72.5 Grade 2 Standard Intermediate Intermediate 
Stage II LGI ± UGI 63 15.9 63 15.9 58.7 Grade 3 Standard Intermediate Intermediate 
Stage I liver ± other organ involvement 20 35.5 59 46.6 40.7 Grade 2-4 Standard/High High High 
Stage II liver ± other organ involvement 23 37.8    Grade 3-4 Standard/High High High 
Stage III liver ± other organ involvement 12 73.1    Grade 3-4 Standard/High High High 
Stage IV liver ± other organ involvement 4 75.0    Grade 4 Standard/High High High 
Stage I skin + stage II LGI ± UGI 15 26.7 34 29.4 64.7 Grade 3 High High High 
Stage II skin + stage II LGI ± UGI 10 40.0    Grade 3    
Stage III skin + stage II LGI ± UGI 9 22.2    Grade 3    
Stage III LGI ± UGI 53 34.3 53 34.3 43.4 Grade 3 High High High 
Stage I skin + stage III LGI ± UGI 9 33.3 21 49.1 52.4 Grade 3 High High High 
Stage II skin + stage III LGI ± UGI 7 65.7    Grade 3    
Stage III skin + stage III LGI ± UGI 5 60.0    Grade 3    
Stage IV skin ± LGI ± UGI 8 25.0 46 32.6 47.8 Grade 4 High High High 
Stage IV LGI ± skin ± UGI 38 34.2    Grade 3    

UGI, upper gastrointestinal; LGI, lower gastrointestinal.

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