Clinical pathological features of BL clusters
| Case . | Sex . | Age, y . | Ethnicity . | Location . | Stage . | EBV status . | Response to therapy . | Cluster . | . |
|---|---|---|---|---|---|---|---|---|---|
| BL1 | M | 10 | African | Lymph node | II | Pos | Complete remission | Cluster 1 | 5 BL EBV+ with diffuse granulomatous reaction |
| BL2 | F | 65 | Caucasian | Lymph node | I | Pos | Spontaneous regression | ||
| BL3 | F | 26 | Caucasian | Oral cavity | II | Pos | Complete remission | ||
| BL4 | M | 12 | African | Oral cavity | I | Pos | Spontaneous regression | ||
| BL5 | F | 47 | Caucasian | Lymph node | I | Pos | Spontaneous regression | ||
| BL6 | M | 9 | African | Lymph node | III | Pos | Complete remission | Cluster 2 | 5 BL EBV+ with typical starry sky |
| BL7 | M | 70 | Caucasian | Na | III | Pos | Complete remission | ||
| BL8 | F | 9 | African | Abdominal mass | III | Pos | Complete remission | ||
| BL9 | M | 3 | African | Na | II | Pos | Complete remission | ||
| BL10 | F | 8 | African | Gastro intestinal tract | II | Pos | Complete remission | ||
| BL11 | F | 5 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | Cluster 3 | 8 BL EBV– with typical starry sky, 3 BL EBV+ with typical starry sky, and 2 BL EBV+ with partial granulomatous reaction |
| BL12 | M | 11 | Caucasian | Oral mucosa | II | Neg | Complete remission | ||
| BL13 | M | 8 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | ||
| BL14 | M | 6 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | ||
| BL15 | M | 50 | Caucasian | Bone marrow | IV | Neg | Relapse | ||
| BL16 | M | 14 | Caucasian | Abdominal mass | III | Neg | Complete remission | ||
| BL17 | M | 8 | Caucasian | Oral mucosa | II | Neg | Complete remission | ||
| BL18 | F | 6 | Caucasian | Na | III | Neg | Remission | ||
| BL19 | M | 12 | African | Na | III | Pos | Not available | ||
| BL20 | F | 63 | Caucasian | Na | II | Pos | Not available | ||
| BL21 | M | 7 | African | Na | III | Pos | Not available | ||
| BL22 | F | 10 | African | Na | II | Pos | Complete remission | ||
| BL23 | F | 4 | African | Abdominal mass | II | Pos | Complete remission |
| Case . | Sex . | Age, y . | Ethnicity . | Location . | Stage . | EBV status . | Response to therapy . | Cluster . | . |
|---|---|---|---|---|---|---|---|---|---|
| BL1 | M | 10 | African | Lymph node | II | Pos | Complete remission | Cluster 1 | 5 BL EBV+ with diffuse granulomatous reaction |
| BL2 | F | 65 | Caucasian | Lymph node | I | Pos | Spontaneous regression | ||
| BL3 | F | 26 | Caucasian | Oral cavity | II | Pos | Complete remission | ||
| BL4 | M | 12 | African | Oral cavity | I | Pos | Spontaneous regression | ||
| BL5 | F | 47 | Caucasian | Lymph node | I | Pos | Spontaneous regression | ||
| BL6 | M | 9 | African | Lymph node | III | Pos | Complete remission | Cluster 2 | 5 BL EBV+ with typical starry sky |
| BL7 | M | 70 | Caucasian | Na | III | Pos | Complete remission | ||
| BL8 | F | 9 | African | Abdominal mass | III | Pos | Complete remission | ||
| BL9 | M | 3 | African | Na | II | Pos | Complete remission | ||
| BL10 | F | 8 | African | Gastro intestinal tract | II | Pos | Complete remission | ||
| BL11 | F | 5 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | Cluster 3 | 8 BL EBV– with typical starry sky, 3 BL EBV+ with typical starry sky, and 2 BL EBV+ with partial granulomatous reaction |
| BL12 | M | 11 | Caucasian | Oral mucosa | II | Neg | Complete remission | ||
| BL13 | M | 8 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | ||
| BL14 | M | 6 | Caucasian | Gastro intestinal tract | III | Neg | Complete remission | ||
| BL15 | M | 50 | Caucasian | Bone marrow | IV | Neg | Relapse | ||
| BL16 | M | 14 | Caucasian | Abdominal mass | III | Neg | Complete remission | ||
| BL17 | M | 8 | Caucasian | Oral mucosa | II | Neg | Complete remission | ||
| BL18 | F | 6 | Caucasian | Na | III | Neg | Remission | ||
| BL19 | M | 12 | African | Na | III | Pos | Not available | ||
| BL20 | F | 63 | Caucasian | Na | II | Pos | Not available | ||
| BL21 | M | 7 | African | Na | III | Pos | Not available | ||
| BL22 | F | 10 | African | Na | II | Pos | Complete remission | ||
| BL23 | F | 4 | African | Abdominal mass | II | Pos | Complete remission |
Cluster 1 consisted of the 5 BL with a diffuse granulomatous reaction, including 3 of 5 cases with spontaneous regression, whereas cluster 2 had 5 EBV+ BL with typical starry sky pattern, and cluster 3 includes 8 EBV– BL with typical starry sky, 2 cases of BL with a partial granulomatous reaction, and 3 cases of EBV+ BL with typical starry sky.
F, female; M, male, Na, not available; neg, negative; pos, positive; BL, Burkitt Lymphoma