Deaths with fostamatinib
| Age and sex . | History . |
|---|---|
| 76; female | Eight prior lines of therapy; achieved complete response response with the combination of fostamatinib + avatrombopag; lost response 4 mo after starting this combination and thereafter needed frequent rescue treatment with IVIG. She subsequently died of a cerebral hemorrhage with no response of ITP to therapies. |
| 81; male | Known hypertensive patient who, before initiation of treatment with fostamatinib, was already receiving antihypertensive therapy; developed an episode of severe hypertension resulting in a severe cerebral hemorrhage. |
| 87; male | COVID-associated pneumonia with 56 000 platelets per μL at the time of death. |
| 84; male | Cardiovascular history with ITP in complete response; died after an acute myocardial infarction. |
| 93; female | Deterioration of general condition with good control of ITP. |
| 88; female | Deterioration of general condition with good control of ITP. |
| 75; male | Ten prior lines of therapy; no response of ITP to any treatment; unknown cause of death. |
| 65; female | Patient with a pacemaker who presented with cardiorespiratory arrest attributed to deterioration of the pacemaker. |
| 82; female | She died as a result of urinary sepsis and had ITP secondary to a marginal splenic lymphoma in progression. |
| Age and sex . | History . |
|---|---|
| 76; female | Eight prior lines of therapy; achieved complete response response with the combination of fostamatinib + avatrombopag; lost response 4 mo after starting this combination and thereafter needed frequent rescue treatment with IVIG. She subsequently died of a cerebral hemorrhage with no response of ITP to therapies. |
| 81; male | Known hypertensive patient who, before initiation of treatment with fostamatinib, was already receiving antihypertensive therapy; developed an episode of severe hypertension resulting in a severe cerebral hemorrhage. |
| 87; male | COVID-associated pneumonia with 56 000 platelets per μL at the time of death. |
| 84; male | Cardiovascular history with ITP in complete response; died after an acute myocardial infarction. |
| 93; female | Deterioration of general condition with good control of ITP. |
| 88; female | Deterioration of general condition with good control of ITP. |
| 75; male | Ten prior lines of therapy; no response of ITP to any treatment; unknown cause of death. |
| 65; female | Patient with a pacemaker who presented with cardiorespiratory arrest attributed to deterioration of the pacemaker. |
| 82; female | She died as a result of urinary sepsis and had ITP secondary to a marginal splenic lymphoma in progression. |