Multivariable analysis for NRM
| Risk factor . | Group . | N . | D . | HR (95% CI) . | P . |
|---|---|---|---|---|---|
| Pretreatment × IPSS-R score change | |||||
| Chemotherapy | Same | 116 | 34 | ||
| Improving | 307 | 56 | 0.49 (0.32-0.77) | .002 | |
| Progressive | 90 | 26 | 0.98 (0.58-1.64) | .9 | |
| HMAs | Same | 86 | 19 | ||
| Improving | 168 | 36 | 0.96 (0.55-1.69) | .9 | |
| Progressive | 59 | 22 | 2.41 (1.30-4.48) | .005 | |
| Other | Same | 42 | 13 | ||
| Improving | 95 | 27 | 0.85 (0.44-1.65) | .6 | |
| Progressive | 53 | 18 | 1.43 (0.69-2.96) | .3 | |
| Untreated | Same | 165 | 55 | ||
| Improving | 67 | 31 | 1.22 (0.78-1.90) | .4 | |
| Progressive | 179 | 45 | 0.71 (0.48-1.07) | .1 | |
| Adjustment factors | |||||
| IPSS-R score at diagnosis | Very low | 78 | 15 | ||
| Low | 309 | 87 | 1.57 (0.90-2.73) | .11 | |
| Intermediate | 453 | 121 | 1.85 (1.05-3.26) | .03 | |
| High | 373 | 107 | 2.47 (1.38-4.42) | .002 | |
| Very high | 214 | 52 | 2.87 (1.53-5.41) | .001 | |
| Interval from diagnosis to HCT | 1427 | 382 | 1.05 (0.99-1.1) | .1 | |
| Age at HCT (dec) | 1427 | 382 | 1.18 (1.06-1.32) | .002 | |
| Conditioning | Standard | 482 | 126 | ||
| Reduced | 945 | 256 | 0.94 (0.74-1.18) | .6 | |
| Donor | Related | 515 | 109 | ||
| Unrelated | 912 | 273 | 1.51 (1.21-1.89) | <.001 |
| Risk factor . | Group . | N . | D . | HR (95% CI) . | P . |
|---|---|---|---|---|---|
| Pretreatment × IPSS-R score change | |||||
| Chemotherapy | Same | 116 | 34 | ||
| Improving | 307 | 56 | 0.49 (0.32-0.77) | .002 | |
| Progressive | 90 | 26 | 0.98 (0.58-1.64) | .9 | |
| HMAs | Same | 86 | 19 | ||
| Improving | 168 | 36 | 0.96 (0.55-1.69) | .9 | |
| Progressive | 59 | 22 | 2.41 (1.30-4.48) | .005 | |
| Other | Same | 42 | 13 | ||
| Improving | 95 | 27 | 0.85 (0.44-1.65) | .6 | |
| Progressive | 53 | 18 | 1.43 (0.69-2.96) | .3 | |
| Untreated | Same | 165 | 55 | ||
| Improving | 67 | 31 | 1.22 (0.78-1.90) | .4 | |
| Progressive | 179 | 45 | 0.71 (0.48-1.07) | .1 | |
| Adjustment factors | |||||
| IPSS-R score at diagnosis | Very low | 78 | 15 | ||
| Low | 309 | 87 | 1.57 (0.90-2.73) | .11 | |
| Intermediate | 453 | 121 | 1.85 (1.05-3.26) | .03 | |
| High | 373 | 107 | 2.47 (1.38-4.42) | .002 | |
| Very high | 214 | 52 | 2.87 (1.53-5.41) | .001 | |
| Interval from diagnosis to HCT | 1427 | 382 | 1.05 (0.99-1.1) | .1 | |
| Age at HCT (dec) | 1427 | 382 | 1.18 (1.06-1.32) | .002 | |
| Conditioning | Standard | 482 | 126 | ||
| Reduced | 945 | 256 | 0.94 (0.74-1.18) | .6 | |
| Donor | Related | 515 | 109 | ||
| Unrelated | 912 | 273 | 1.51 (1.21-1.89) | <.001 |
Multivariable Cox cause-specific hazards models for NRM, with interactions between pretreatment and change in IPSS-R score. The total number of patients in each group and the number of events are reported in the N and D columns, respectively. The interval from diagnosis to HCT is in years, and age at HCT is in decades. Effect estimates are given with 95% CIs. Corresponding P values are calculated using the Wald test. All interaction effects between pretreatment and IPSS-R score change include both corresponding main effects.
dec, decades.