Baseline characteristics of total cohort and subgroups according to treatment before transplantation
| . | Group . | Total . | Untreated . | Chemotherapy . | HMAs . | Other . | P . |
|---|---|---|---|---|---|---|---|
| N (%) . | n (%) . | n (%) . | n (%) . | n (%) . | |||
| Total | 1482 (100) | 423 (28.5) | 534 (36.0) | 328 (22.1) | 197 (13.3) | ||
| Patient sex | Male | 897 (60.5) | 256 (60.5) | 326 (61.0) | 193 (58.8) | 122 (61.9) | .893 |
| Female | 585 (39.5) | 167 (39.5) | 208 (39.0) | 135 (41.2) | 75 (38.1) | ||
| IPSS-R at diagnosis | Very low | 81 (5.5) | 39 (9.2) | 21 (3.9) | 11 (3.4) | 10 (5.1) | <.001 |
| Low | 317 (21.4) | 123 (29.1) | 108 (20.2) | 37 (11.3) | 49 (24.9) | ||
| Intermediate | 468 (31.6) | 149 (35.2) | 152 (28.5) | 112 (34.1) | 55 (27.9) | ||
| High | 390 (26.3) | 90 (21.3) | 153 (28.7) | 101 (30.8) | 46 (23.4) | ||
| Very high | 226 (15.2) | 22 (5.2) | 100 (18.7) | 67 (20.4) | 37 (18.8) | ||
| Age at HCT (y) | Median (IQR) | 59 (50.8-64) | 55.7 (45.1-62.4) | 58.2 (50.6-63.5) | 61.7 (56.4-66.3) | 59.7 (54-64.3) | <.001 |
| Interval from diagnosis to HCT (mo) | Median (IQR) | 9 (5.7-17.2) | 7.9 (4.8-16) | 7.7 (5.1-15.5) | 9.6 (6.8-14.9) | 15 (8.5-30.9) | <.001 |
| Stem cell source | BM | 159 (10.7) | 52 (12.3) | 51 (9.6) | 32 (9.8) | 24 (12.2) | .001 |
| PB | 1253 (84.6) | 357 (84.4) | 452 (84.8) | 289 (88.1) | 155 (78.7) | ||
| BM + PB | 9 (0.6) | 5 (1.2) | 1 (0.2) | 2 (0.6) | 1 (0.5) | ||
| CB | 60 (4.1) | 9 (2.1) | 29 (5.4) | 5 (1.5) | 17 (8.6) | ||
| Donor | Related | 537 (36.2) | 159 (37.6) | 197 (36.9) | 114 (34.8) | 67 (34.0) | .761 |
| Unrelated | 945 (63.8) | 264 (62.4) | 337 (63.1) | 214 (65.2) | 130 (66.0) | ||
| TBI | No | 1222 (82.7) | 361 (85.7) | 414 (77.7) | 288 (88.3) | 159 (80.7) | <.001 |
| Yes | 255 (17.3) | 60 (14.3) | 119 (22.3) | 38 (11.7) | 38 (19.3) | ||
| Conditioning | Standard | 493 (33.4) | 154 (36.4) | 182 (34.3) | 90 (27.5) | 67 (34.2) | .071 |
| Reduced | 984 (66.6) | 269 (63.6) | 349 (65.7) | 237 (72.5) | 129 (65.8) |
| . | Group . | Total . | Untreated . | Chemotherapy . | HMAs . | Other . | P . |
|---|---|---|---|---|---|---|---|
| N (%) . | n (%) . | n (%) . | n (%) . | n (%) . | |||
| Total | 1482 (100) | 423 (28.5) | 534 (36.0) | 328 (22.1) | 197 (13.3) | ||
| Patient sex | Male | 897 (60.5) | 256 (60.5) | 326 (61.0) | 193 (58.8) | 122 (61.9) | .893 |
| Female | 585 (39.5) | 167 (39.5) | 208 (39.0) | 135 (41.2) | 75 (38.1) | ||
| IPSS-R at diagnosis | Very low | 81 (5.5) | 39 (9.2) | 21 (3.9) | 11 (3.4) | 10 (5.1) | <.001 |
| Low | 317 (21.4) | 123 (29.1) | 108 (20.2) | 37 (11.3) | 49 (24.9) | ||
| Intermediate | 468 (31.6) | 149 (35.2) | 152 (28.5) | 112 (34.1) | 55 (27.9) | ||
| High | 390 (26.3) | 90 (21.3) | 153 (28.7) | 101 (30.8) | 46 (23.4) | ||
| Very high | 226 (15.2) | 22 (5.2) | 100 (18.7) | 67 (20.4) | 37 (18.8) | ||
| Age at HCT (y) | Median (IQR) | 59 (50.8-64) | 55.7 (45.1-62.4) | 58.2 (50.6-63.5) | 61.7 (56.4-66.3) | 59.7 (54-64.3) | <.001 |
| Interval from diagnosis to HCT (mo) | Median (IQR) | 9 (5.7-17.2) | 7.9 (4.8-16) | 7.7 (5.1-15.5) | 9.6 (6.8-14.9) | 15 (8.5-30.9) | <.001 |
| Stem cell source | BM | 159 (10.7) | 52 (12.3) | 51 (9.6) | 32 (9.8) | 24 (12.2) | .001 |
| PB | 1253 (84.6) | 357 (84.4) | 452 (84.8) | 289 (88.1) | 155 (78.7) | ||
| BM + PB | 9 (0.6) | 5 (1.2) | 1 (0.2) | 2 (0.6) | 1 (0.5) | ||
| CB | 60 (4.1) | 9 (2.1) | 29 (5.4) | 5 (1.5) | 17 (8.6) | ||
| Donor | Related | 537 (36.2) | 159 (37.6) | 197 (36.9) | 114 (34.8) | 67 (34.0) | .761 |
| Unrelated | 945 (63.8) | 264 (62.4) | 337 (63.1) | 214 (65.2) | 130 (66.0) | ||
| TBI | No | 1222 (82.7) | 361 (85.7) | 414 (77.7) | 288 (88.3) | 159 (80.7) | <.001 |
| Yes | 255 (17.3) | 60 (14.3) | 119 (22.3) | 38 (11.7) | 38 (19.3) | ||
| Conditioning | Standard | 493 (33.4) | 154 (36.4) | 182 (34.3) | 90 (27.5) | 67 (34.2) | .071 |
| Reduced | 984 (66.6) | 269 (63.6) | 349 (65.7) | 237 (72.5) | 129 (65.8) |
Patient/transplant characteristics in the whole cohort and stratified by pretreatment. P values were obtained using the χ2 test for categorical variables, and the Kruskal-Wallis test for continuous data. Data were missing on stem cell source (n = 1), TBI (n = 5), and conditioning (n = 5).
CB, cord blood; IQR, interquartile range; PB, peripheral blood; TBI, total body irradiation.