Concordance of significance for MRD with PFS and OS (all-NDMM population)
| study . | Treatment effect on MRD∗ (2-sided test) P value . | Treatment effect on PFS∗ (2-sided test) P value . | Treatment effect on OS∗ (2-sided test) P value . |
|---|---|---|---|
| TE NDMM | |||
| 1.1A | .98 | .385 | .686 |
| 1.1B | .131 | .605 | .901 |
| 1.3 | <.001 | <.001 | .008 |
| TIE NDMM | |||
| 1.4 | .629 | .399 | .232 |
| 1.2 | .264 | .038 | .806 |
| 1.5 | <.001 | <.001 | <.001 |
| 1.6 | <.001 | <.001 | <.001 |
| 1.7 | <.001 | <.001 | .377 |
| study . | Treatment effect on MRD∗ (2-sided test) P value . | Treatment effect on PFS∗ (2-sided test) P value . | Treatment effect on OS∗ (2-sided test) P value . |
|---|---|---|---|
| TE NDMM | |||
| 1.1A | .98 | .385 | .686 |
| 1.1B | .131 | .605 | .901 |
| 1.3 | <.001 | <.001 | .008 |
| TIE NDMM | |||
| 1.4 | .629 | .399 | .232 |
| 1.2 | .264 | .038 | .806 |
| 1.5 | <.001 | <.001 | <.001 |
| 1.6 | <.001 | <.001 | <.001 |
| 1.7 | <.001 | <.001 | .377 |
Does not include stratification factors used in randomization.