Baseline fibrin clot properties and modifiers in relation to patency
| . | Patency (n = 29) . | No patency (n = 50) . | P value . | Adjusted P value . |
|---|---|---|---|---|
| Turbidimetric clotting assay | ||||
| Lag time, s | 462 (402-513) | 384 (335-456) | .001 | .090 |
| Maximal turbidity (OD) | 0.52 (±0.26) | 0.69 (±0.25) | .006 | .013 |
| Turbidimetric lysis assay | ||||
| Time to 50% lysis, s | 1038 (879-1395) | 1041 (915-1388) | .854 | .162 |
| Lysis rate (% per min) | 3.90 (±1.45) | 4.07 (±1.75) | .658 | .801 |
| Other fibrin clot properties∗ | ||||
| Permeation (10–9 cm2) | 3.74 (1.66-6.83) | 2.75 (1.46-5.55) | .289 | .172 |
| Fiber density (n per 100 μm) | 11.9 (±2.6) | 13.0 (±3.0) | .132 | .083 |
| Fibrin clot modifiers | ||||
| Fibrinogen, g/L | 4.43 (±1.49) | 5.50 (±1.51) | .003 | .011 |
| CRP, mg/L | 10.57 (3.71-24.19) | 24.21 (8.34-68.59) | .015 | .087 |
| . | Patency (n = 29) . | No patency (n = 50) . | P value . | Adjusted P value . |
|---|---|---|---|---|
| Turbidimetric clotting assay | ||||
| Lag time, s | 462 (402-513) | 384 (335-456) | .001 | .090 |
| Maximal turbidity (OD) | 0.52 (±0.26) | 0.69 (±0.25) | .006 | .013 |
| Turbidimetric lysis assay | ||||
| Time to 50% lysis, s | 1038 (879-1395) | 1041 (915-1388) | .854 | .162 |
| Lysis rate (% per min) | 3.90 (±1.45) | 4.07 (±1.75) | .658 | .801 |
| Other fibrin clot properties∗ | ||||
| Permeation (10–9 cm2) | 3.74 (1.66-6.83) | 2.75 (1.46-5.55) | .289 | .172 |
| Fiber density (n per 100 μm) | 11.9 (±2.6) | 13.0 (±3.0) | .132 | .083 |
| Fibrin clot modifiers | ||||
| Fibrinogen, g/L | 4.43 (±1.49) | 5.50 (±1.51) | .003 | .011 |
| CRP, mg/L | 10.57 (3.71-24.19) | 24.21 (8.34-68.59) | .015 | .087 |
Of 91 patients, 12 had unmeasurable fibrin clots, which left 79 patients for analysis. Levels were given as mean (standard deviation) or median (interquartile range). Adjusted P values calculated in multivariable logistic regression model including treatment group, thrombus load, and body mass index. There were no significant interactions with treatment group.
OD, optical density.
Measured in selection of patients (n = 67).