Scenario analyses of base-case results and NMBs using alternative IV iron supplementation, ferumoxytol and iron dextran
| Strategy . | Cost . | Incremental cost . | Effectiveness (QALY) . | Incremental effectiveness (QALY) . | NMB . | iNMB (95% credible interval) . |
|---|---|---|---|---|---|---|
| Health system perspective (ferumoxytol) | ||||||
| Bevacizumab | $407 000 | — | 9.3 | 1.0 | $994 000 | $354 000 (181 000-652 000) |
| SOC | $598 000 | 191 000 | 8.3 | — | $640 000 | |
| Societal perspective (ferumoxytol) | ||||||
| Bevacizumab | $414 000 | — | 9.3 | 1.0 | $987 000 | $364 000 (182 000-680 000) |
| SOC | $615 000 | $201 000 | 8.3 | — | $623 000 | |
| Health system perspective (iron dextran) | ||||||
| Bevacizumab | $398 000 | — | 9.3 | 1.0 | $1 003 000 | $316 000 (147 000-567 000) |
| SOC | $552 000 | $154 000 | 8.3 | — | $687 000 | |
| Societal perspective (iron dextran) | ||||||
| Bevacizumab | $405 000 | — | 9.3 | 1.0 | $996 000 | $326 000 (151 000-592 000) |
| SOC | $569 000 | $164 000 | 8.3 | — | $670 000 | |
| Strategy . | Cost . | Incremental cost . | Effectiveness (QALY) . | Incremental effectiveness (QALY) . | NMB . | iNMB (95% credible interval) . |
|---|---|---|---|---|---|---|
| Health system perspective (ferumoxytol) | ||||||
| Bevacizumab | $407 000 | — | 9.3 | 1.0 | $994 000 | $354 000 (181 000-652 000) |
| SOC | $598 000 | 191 000 | 8.3 | — | $640 000 | |
| Societal perspective (ferumoxytol) | ||||||
| Bevacizumab | $414 000 | — | 9.3 | 1.0 | $987 000 | $364 000 (182 000-680 000) |
| SOC | $615 000 | $201 000 | 8.3 | — | $623 000 | |
| Health system perspective (iron dextran) | ||||||
| Bevacizumab | $398 000 | — | 9.3 | 1.0 | $1 003 000 | $316 000 (147 000-567 000) |
| SOC | $552 000 | $154 000 | 8.3 | — | $687 000 | |
| Societal perspective (iron dextran) | ||||||
| Bevacizumab | $405 000 | — | 9.3 | 1.0 | $996 000 | $326 000 (151 000-592 000) |
| SOC | $569 000 | $164 000 | 8.3 | — | $670 000 | |
Bevacizumab remains a cost-saving treatment with added NMB regardless of choice of iron supplementation.