Distribution of parameters between SJB and NSB
| Variable . | SJB median (IQR) . | NSB median (IQR) . | Hazard ratio (95% CI) . | P value . | AUC . |
|---|---|---|---|---|---|
| Number of patients | 10 | 30 | – | – | – |
| Age, y | 55 (41-61) | 41 (28-52) | 1.0 (0.97-1.06) | .59 | 0.58 |
| BMI | 23.6 (20.1-28.2) | 23.7 (21.4-24.7) | 0.96 (0.84-1.1) | .51 | 0.52 |
| Activity intensity | 1 (0-1) | 1 (0-2) | 0.7 (0.4-1.3) | .28 | 0.65 |
| HJHS | 25 (14-35) | 13 (3-16) | 1.0 (0.98-1.1) | .19 | 0.66 |
| HEAD-US | 24 (20-25) | 7 (1-11) | 1.08 (1.0-1.2) | .06 | 0.78 |
| Synovitis total score | 1 (1-2) | 1 (0-1) | 3.05 (1.15-8.12) | .03 | 0.79 |
| Maximum synovitis score | 1 (1-2) | 1 (0-1) | 4.6, (1.0 - 7.1) | .04 | 0.77 |
| Emicizumab | 40.9 (33.3-55.2) | 51.0 (42.2-63.1) | 0.98 (0.95-1.0) | .37 | 0.63 |
| NATEM | |||||
| CT, s | 865.0 (755.0-1006.5) | 832.4 (722.1-899.8) | 1.0 (0.99-1.0) | .26 | 0.62 |
| CFT, s | 176.0 (145.5-237.6) | 187.7 (164.4-222.7) | 1.0 (0.99-1.0) | .49 | 0.55 |
| MCF, mm | 60.5 (56-63) | 58.3 (55.5-60.6) | 1.0 (0.92-1.1) | .73 | 0.45 |
| MCF time, s | 1684.5 (1612-1701) | 1712.8 (1485-1855) | 1.0 (0.99-1.0) | .94 | 0.41 |
| Alpha angle, ° | 57.0 (51.8-63.0) | 57.8 (54.5-61.0) | 0.96 (0.89-1.0) | .42 | 0.58 |
| TGA | |||||
| Lag time, min | 8.3 (7.8-12.1) | 8.1 (7.4-8.8) | 1.06 (0.8-1.4) | .71 | 0.41 |
| ETP, nM × min | 785.1 (632.7-997.0) | 1053.0 (993.6-1282.1) | 0.99 (0.99-1.0) | .07 | 0.65 |
| Peak T, nM | 51.1 (38.4-63.5) | 77.3 (64.5-94.2) | 0.96 (0.94-1.0) | .06 | 0.65 |
| TTPeak, min | 20.8 (20.2-24.2) | 18.6 (17.8-19.5) | 1.06 (0.89-1.3) | .52 | 0.57 |
| Vel I, nM/min | 4.8 (3.0-5.2) | 7.7 (6.5-9.4) | 0.75 (0.5-1.0) | .07 | 0.63 |
| Variable . | SJB median (IQR) . | NSB median (IQR) . | Hazard ratio (95% CI) . | P value . | AUC . |
|---|---|---|---|---|---|
| Number of patients | 10 | 30 | – | – | – |
| Age, y | 55 (41-61) | 41 (28-52) | 1.0 (0.97-1.06) | .59 | 0.58 |
| BMI | 23.6 (20.1-28.2) | 23.7 (21.4-24.7) | 0.96 (0.84-1.1) | .51 | 0.52 |
| Activity intensity | 1 (0-1) | 1 (0-2) | 0.7 (0.4-1.3) | .28 | 0.65 |
| HJHS | 25 (14-35) | 13 (3-16) | 1.0 (0.98-1.1) | .19 | 0.66 |
| HEAD-US | 24 (20-25) | 7 (1-11) | 1.08 (1.0-1.2) | .06 | 0.78 |
| Synovitis total score | 1 (1-2) | 1 (0-1) | 3.05 (1.15-8.12) | .03 | 0.79 |
| Maximum synovitis score | 1 (1-2) | 1 (0-1) | 4.6, (1.0 - 7.1) | .04 | 0.77 |
| Emicizumab | 40.9 (33.3-55.2) | 51.0 (42.2-63.1) | 0.98 (0.95-1.0) | .37 | 0.63 |
| NATEM | |||||
| CT, s | 865.0 (755.0-1006.5) | 832.4 (722.1-899.8) | 1.0 (0.99-1.0) | .26 | 0.62 |
| CFT, s | 176.0 (145.5-237.6) | 187.7 (164.4-222.7) | 1.0 (0.99-1.0) | .49 | 0.55 |
| MCF, mm | 60.5 (56-63) | 58.3 (55.5-60.6) | 1.0 (0.92-1.1) | .73 | 0.45 |
| MCF time, s | 1684.5 (1612-1701) | 1712.8 (1485-1855) | 1.0 (0.99-1.0) | .94 | 0.41 |
| Alpha angle, ° | 57.0 (51.8-63.0) | 57.8 (54.5-61.0) | 0.96 (0.89-1.0) | .42 | 0.58 |
| TGA | |||||
| Lag time, min | 8.3 (7.8-12.1) | 8.1 (7.4-8.8) | 1.06 (0.8-1.4) | .71 | 0.41 |
| ETP, nM × min | 785.1 (632.7-997.0) | 1053.0 (993.6-1282.1) | 0.99 (0.99-1.0) | .07 | 0.65 |
| Peak T, nM | 51.1 (38.4-63.5) | 77.3 (64.5-94.2) | 0.96 (0.94-1.0) | .06 | 0.65 |
| TTPeak, min | 20.8 (20.2-24.2) | 18.6 (17.8-19.5) | 1.06 (0.89-1.3) | .52 | 0.57 |
| Vel I, nM/min | 4.8 (3.0-5.2) | 7.7 (6.5-9.4) | 0.75 (0.5-1.0) | .07 | 0.63 |
The table represents the hazard ratio, P value, and AUC extracted from the Cox proportional hazards model.
BMI, body mass index; CI, confidence interval; CFT, clot formation time; CT, clotting time; NSB, nonspontaneous bleeders; SJB, spontaneous joint bleeders; TTPeak, time to peak; Vel I, velocity index.