| Acutely ill patients: pharmacological prophylaxis addressing the following comparisons |
| 1. Parenteral anticoagulant vs no parenteral anticoagulant |
| 2. LMWH vs unfractionated heparin |
| 3. Fondaparinux vs low molecular weight heparin or unfractionated heparin |
| Critically ill patients: pharmacological prophylaxis addressing the following comparisons |
| 4. Any heparin vs no heparin |
| 5. LMWH vs unfractionated heparin |
| Acutely or critically ill patients: mechanical prophylaxis addressing the following comparisons |
| 6. Mechanical vs pharmacological prophylaxis |
| 7. Mechanical vs no prophylaxis |
| 8. Mechanical combined with pharmacological vs mechanical alone |
| 9. Mechanical combined with pharmacological vs pharmacological alone |
| 10. Intermittent pneumatic compression stockings vs graduated compression stockings |
| DOACs in acutely ill medical patients |
| 11. DOACs vs prophylactic LMWH |
| 12. Extended-duration DOACs vs shorter-duration non-DOAC prophylaxis |
| Extended-duration outpatient prophylaxis vs inpatient-only prophylaxis |
| 13. Acutely ill medical patients |
| 14. Critically ill medical patients |
| Chronically ill patients or nursing home patients |
| 15. Pharmacological prophylaxis vs no prophylaxis |
| Medical outpatients with minor provoking factors for VTE (eg, immobility, minor injury, illness, infection) |
| 16. Prophylaxis vs no prophylaxis |
| Long-distance travelers: prophylaxis addressing the following comparisons |
| 17. Graduated compression stockings |
| 18. LMWH |
| 19. Aspirin vs no prophylaxis |
| Acutely ill patients: pharmacological prophylaxis addressing the following comparisons |
| 1. Parenteral anticoagulant vs no parenteral anticoagulant |
| 2. LMWH vs unfractionated heparin |
| 3. Fondaparinux vs low molecular weight heparin or unfractionated heparin |
| Critically ill patients: pharmacological prophylaxis addressing the following comparisons |
| 4. Any heparin vs no heparin |
| 5. LMWH vs unfractionated heparin |
| Acutely or critically ill patients: mechanical prophylaxis addressing the following comparisons |
| 6. Mechanical vs pharmacological prophylaxis |
| 7. Mechanical vs no prophylaxis |
| 8. Mechanical combined with pharmacological vs mechanical alone |
| 9. Mechanical combined with pharmacological vs pharmacological alone |
| 10. Intermittent pneumatic compression stockings vs graduated compression stockings |
| DOACs in acutely ill medical patients |
| 11. DOACs vs prophylactic LMWH |
| 12. Extended-duration DOACs vs shorter-duration non-DOAC prophylaxis |
| Extended-duration outpatient prophylaxis vs inpatient-only prophylaxis |
| 13. Acutely ill medical patients |
| 14. Critically ill medical patients |
| Chronically ill patients or nursing home patients |
| 15. Pharmacological prophylaxis vs no prophylaxis |
| Medical outpatients with minor provoking factors for VTE (eg, immobility, minor injury, illness, infection) |
| 16. Prophylaxis vs no prophylaxis |
| Long-distance travelers: prophylaxis addressing the following comparisons |
| 17. Graduated compression stockings |
| 18. LMWH |
| 19. Aspirin vs no prophylaxis |