FXI binding partners presented by apple domain
| FXI binding partner . | Required residues for binding . | Reference . |
|---|---|---|
| A1 domain | ||
| Thrombin | Ala45-Arg54, Val59-Arg70, Glu66, Lys83, and Gln84 | 5,8,13,14 |
| HK | Phe56-Ser86 Val69-Arg83 | 15,16 |
| A2 domain | ||
| HK | Asn106, Tyr107, Asn108, His127, Thr132, Ala134, His143, Ile146, Leu148, and His151 | 17,18 |
| FXIIa | Unknown | 13,19 |
| A3 domain | ||
| Thrombin | Asp204 | 7 |
| FIX | Ile183-Val191, Ser195-Ile197, and Phe260-Ser265 | 20 |
| GPIbα receptor | Ser248, Arg250, Lys255, Phe260, and Gln263 | 21-23 |
| HK | Ala193-Ala205, Leu239-Phe260 | 24 |
| FV | Unknown | 25 |
| Polyanions | Arg250, Ile251, Lys252, Lys253, Ser254, Lys255 | 26,27 |
| Skeletal muscle myosin | Unknown | 28 |
| FXIIa | Unknown | 29 |
| A4 domain | ||
| Thrombin | Asp280 and Lys301 | 7 |
| Dimerization | Leu284, Ile290, Tyr329, Lys331, and Glu287 | 30 |
| FXIIa | Ala317-Gly350 | 31 |
| Serine protease domain | ||
| Thrombin | Pro520 | 7 |
| Polyanions | Lys529, Arg530, Arg532, Lys534, and Lys538 | 32 |
| AT, C1-inhibitor, nexin-1, nexin-2, α-1 antitrypsin | Arg504, Lys505, Arg507, and Lys509 | 33 |
| FXI binding partner . | Required residues for binding . | Reference . |
|---|---|---|
| A1 domain | ||
| Thrombin | Ala45-Arg54, Val59-Arg70, Glu66, Lys83, and Gln84 | 5,8,13,14 |
| HK | Phe56-Ser86 Val69-Arg83 | 15,16 |
| A2 domain | ||
| HK | Asn106, Tyr107, Asn108, His127, Thr132, Ala134, His143, Ile146, Leu148, and His151 | 17,18 |
| FXIIa | Unknown | 13,19 |
| A3 domain | ||
| Thrombin | Asp204 | 7 |
| FIX | Ile183-Val191, Ser195-Ile197, and Phe260-Ser265 | 20 |
| GPIbα receptor | Ser248, Arg250, Lys255, Phe260, and Gln263 | 21-23 |
| HK | Ala193-Ala205, Leu239-Phe260 | 24 |
| FV | Unknown | 25 |
| Polyanions | Arg250, Ile251, Lys252, Lys253, Ser254, Lys255 | 26,27 |
| Skeletal muscle myosin | Unknown | 28 |
| FXIIa | Unknown | 29 |
| A4 domain | ||
| Thrombin | Asp280 and Lys301 | 7 |
| Dimerization | Leu284, Ile290, Tyr329, Lys331, and Glu287 | 30 |
| FXIIa | Ala317-Gly350 | 31 |
| Serine protease domain | ||
| Thrombin | Pro520 | 7 |
| Polyanions | Lys529, Arg530, Arg532, Lys534, and Lys538 | 32 |
| AT, C1-inhibitor, nexin-1, nexin-2, α-1 antitrypsin | Arg504, Lys505, Arg507, and Lys509 | 33 |