Table 3. Acquired factor deficiencies... | American Society of Hematology

Table 3.

Acquired factor deficiencies associated with bleeding

Deficiency	Prolonged aPTT and PT				Prolonged aPTT, nl PT			Prolonged PT, nl aPTT	Normal aPTT and PT∗
Deficiency	Fibrinogen	FII	FV⁴⁵	FX⁴⁶	FVIII	FIX	FXI	FVII	FXIII^47-49
Predisposing factors	DIC Liver disease Trauma MGUS, MM⁵⁰ Asparaginase⁵¹	Liver disease Sepsis Vitamin K deficiency	Inhibitor Topical bovine thrombin Antibiotics	Amyloidosis Liver disease Vitamin K deficiency	Inhibitor DIC AVWS with reduced FVIII	Inhibitor DIC Liver disease Vitamin K deficiency	Inhibitor DIC Liver disease	Liver disease Sepsis Vitamin K deficiency Vitamin K antagonist	Inhibitor Liver disease Post op Cardiovascular bypass Inflammatory bowel disease

Deficiency	Prolonged aPTT and PT				Prolonged aPTT, nl PT			Prolonged PT, nl aPTT	Normal aPTT and PT∗
Deficiency	Fibrinogen	FII	FV⁴⁵	FX⁴⁶	FVIII	FIX	FXI	FVII	FXIII^47-49
Predisposing factors	DIC Liver disease Trauma MGUS, MM⁵⁰ Asparaginase⁵¹	Liver disease Sepsis Vitamin K deficiency	Inhibitor Topical bovine thrombin Antibiotics	Amyloidosis Liver disease Vitamin K deficiency	Inhibitor DIC AVWS with reduced FVIII	Inhibitor DIC Liver disease Vitamin K deficiency	Inhibitor DIC Liver disease	Liver disease Sepsis Vitamin K deficiency Vitamin K antagonist	Inhibitor Liver disease Post op Cardiovascular bypass Inflammatory bowel disease

DIC, disseminated intravascular coagulation; MGUS, monoclonal gammopathy of unknown significance; nl, normal; PT, prothrombin time.

∗

Acquired platelet dysfunction from medications/exposures should also be considered when a patient presents with new bleeding symptoms with a normal aPTT and PT.

View Large

This Feature Is Available To Subscribers Only