Number of RBCs received before the first antibody detection in n = 643 patients, for whom chronological analysis and analysis of groups of antibodies could be performed
| . | All antibodies . | All antibodies except WAAs . | All antibodies with specificity (excluding WAAs and AUS) . | Analysis for groups of antibodies (analyzed separately from other specificities) . | ||||
|---|---|---|---|---|---|---|---|---|
| WAAs only . | RH-K only . | AEP only . | HFA only . | LFA only . | ||||
| Patients, n | 643∗ | 588∗ | 478∗ | 424∗ | 205∗ | 198∗ | 61∗ | 137∗ |
| Mean | 23.03 | 27.63 | 26.99 | 24.17 | 37.38 | 14.80 | 8.89 | 49.55 |
| SD | 58.98 | 72.17 | 73.44 | 45.55 | 87.58 | 36.30 | 11.09 | 99.80 |
| Minimum | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Q1 (25%) | 3 | 3 | 3 | 3 | 4 | 3 | 3 | 5 |
| Median | 6 | 7 | 6 | 8 | 10 | 6 | 5 | 13 |
| Q3 (75%) | 17 | 20 | 17 | 21 | 30 | 10 | 10 | 42 |
| 90% | 52 | 56 | 55 | 66 | 87 | 28 | 16 | 105 |
| 95% | 91 | 103 | 105 | 100 | 165 | 64 | 24 | 257 |
| Maximum | 623 | 698 | 700 | 361 | 700 | 306 | 64 | 623 |
| . | All antibodies . | All antibodies except WAAs . | All antibodies with specificity (excluding WAAs and AUS) . | Analysis for groups of antibodies (analyzed separately from other specificities) . | ||||
|---|---|---|---|---|---|---|---|---|
| WAAs only . | RH-K only . | AEP only . | HFA only . | LFA only . | ||||
| Patients, n | 643∗ | 588∗ | 478∗ | 424∗ | 205∗ | 198∗ | 61∗ | 137∗ |
| Mean | 23.03 | 27.63 | 26.99 | 24.17 | 37.38 | 14.80 | 8.89 | 49.55 |
| SD | 58.98 | 72.17 | 73.44 | 45.55 | 87.58 | 36.30 | 11.09 | 99.80 |
| Minimum | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Q1 (25%) | 3 | 3 | 3 | 3 | 4 | 3 | 3 | 5 |
| Median | 6 | 7 | 6 | 8 | 10 | 6 | 5 | 13 |
| Q3 (75%) | 17 | 20 | 17 | 21 | 30 | 10 | 10 | 42 |
| 90% | 52 | 56 | 55 | 66 | 87 | 28 | 16 | 105 |
| 95% | 91 | 103 | 105 | 100 | 165 | 64 | 24 | 257 |
| Maximum | 623 | 698 | 700 | 361 | 700 | 306 | 64 | 623 |
Q1, first quartile; Q3, third quartile; SD, standard deviation.
HFAs: n = 30 anti-Fy3, n = 8 anti-Fy5, n = 4 anti-U, n = 2 anti-Jsb, n = 1 each anti-Joa, anti-Ena, anti-Hy with anti-Fy3, and n = 14 were not identified at first detection.
Highlighted cells (bold): 75% of patients start forming antibodies by the 17th RBCu (or by the 20th unit when WAAs are excluded); 90% who form antibodies to HFA will have made their first by the 16th RBC unit.
Columns are not mutually exclusive because the first antibody detection could reveal ≥2 specificities identified on the same date (eg, anti-D and anti-Jkb or a WAA and an antibody to a LFA).