List of single mutations that, when detected, should exclude one or more 2G TKIs or ponatinib from the decision algorithm. All mutations except V299L, T315A, T315L, and T315M are also resistant to imatinib. Asciminib has been included, in brackets, for some mutations based on in vitro or in vivo data. This list will grow once asciminib resistance mutations are fully elucidated.