Table 1. Spectrum of mutations detected... | American Society of Hematology

Table 1.

Spectrum of mutations detected in blood donors

Cohort	Frequent donor	Control donor
Characteristics	n = 105, median age, 66 y Median # donations, 120	n = 103, median age, 63 y Median # donations, 5
Low-risk mutations¹³	DNMT3A (34)^a TET2 (14) KRAS (2) CBL (1) ASXL1 (1)	DNMT3A (23)^a TET2 (7) CBL (1) ASXL1 (1)
High-risk mutations²³	RUNX1 (1) SRSF2 (1)	RUNX1 (1) U2AF1 (1)
Unclear risk mutations³⁴	KMT2C (5), MPL (3), SH2B3 (2), SF3B1 (2)^b, BCR (2), EED (2), and 1 each of SMC1A, TERT, WAS, HNRNPK, JAK3, ATM, ASXL2, STAT3, LRRC4, KAT6A, KDM6A, IKZF1, FAM154B, EP300, ELANE, DNMT1, CTCF, CRLF2, and BRINP3	SMC1A (2), HNRNPK (2), FAM47A (2), DNM2 (2), BRCA2 (2), and 1 each of KMT2C, SH2B3, SF3B1^b, BCR, WAS, TERT, JAK3, ATM, ASXL2, TAL1, SETBP1, NPAT, NOTCH1, IL7R, GJB3, FIP1L1, DDX41, CUX1, CHEK2, BRCA1, ANKRD26, and ABL1

Cohort	Frequent donor	Control donor
Characteristics	n = 105, median age, 66 y Median # donations, 120	n = 103, median age, 63 y Median # donations, 5
Low-risk mutations¹³	DNMT3A (34)^a TET2 (14) KRAS (2) CBL (1) ASXL1 (1)	DNMT3A (23)^a TET2 (7) CBL (1) ASXL1 (1)
High-risk mutations²³	RUNX1 (1) SRSF2 (1)	RUNX1 (1) U2AF1 (1)
Unclear risk mutations³⁴	KMT2C (5), MPL (3), SH2B3 (2), SF3B1 (2)^b, BCR (2), EED (2), and 1 each of SMC1A, TERT, WAS, HNRNPK, JAK3, ATM, ASXL2, STAT3, LRRC4, KAT6A, KDM6A, IKZF1, FAM154B, EP300, ELANE, DNMT1, CTCF, CRLF2, and BRINP3	SMC1A (2), HNRNPK (2), FAM47A (2), DNM2 (2), BRCA2 (2), and 1 each of KMT2C, SH2B3, SF3B1^b, BCR, WAS, TERT, JAK3, ATM, ASXL2, TAL1, SETBP1, NPAT, NOTCH1, IL7R, GJB3, FIP1L1, DDX41, CUX1, CHEK2, BRCA1, ANKRD26, and ABL1

Including 3 × and 2 × R882 mutations in frequent and control donors, respectively.

Assigned as unclear risk mutation due to controversial predictions in the literature.

Data compiled from Karpova et al.³²