Univariate HR and 95% CI for malaria infection (limited to 4 episodes) for confirmed malaria infections
| Parameter . | Confirmed malaria infections (N = 346) . | ||
|---|---|---|---|
| HR . | 95% CI . | P value . | |
| Age (per y) | 1.01 | 0.96-1.05 | .70 |
| Sex (male vs female) | 1.06 | 0.85-1.33 | .58 |
| MTD reached | 0.63 | 0.49-0.81 | .0004 |
| HbF ratio (per 10% increase) | 0.94 | 0.83-1.05 | .26 |
| Hb (per 1 g/dL increase) | 0.78 | 0.73-0.85 | <.0001 |
| ANC (per doubling) | 1.30 | 1.05-1.61 | .017 |
| MCV (per 10 fL increase) | 1.09 | 0.99-1.19 | .08 |
| Malaria season (vs low) | |||
| High | 1.11 | 0.76-1.62 | .58 |
| Moderate | 1.02 | 0.79-1.31 | .90 |
| Spleen status (vs nonpalpable) | |||
| Palpable (1-4 cm) | 2.05 | 1.44-2.94 | .0001 |
| Palpable (≥5 cm) | 1.45 | 0.91-2.29 | .12 |
| Splenectomy | 1.40 | 0.82-2.39 | .21 |
| α-Thalassemia (vs 4 genes) | |||
| 3 genes (−α3.7/αα) | 0.88 | 0.70-1.12 | .30 |
| 2 genes (−α3.7/−α3.7) | 0.69 | 0.49-0.96 | .026 |
| G6PD genotype (vs normal) | |||
| Male (hemizygous A-) | 1.09 | 0.76-1.56 | .64 |
| Female (heterozygous A) | 1.04 | 0.67-1.61 | .86 |
| Parameter . | Confirmed malaria infections (N = 346) . | ||
|---|---|---|---|
| HR . | 95% CI . | P value . | |
| Age (per y) | 1.01 | 0.96-1.05 | .70 |
| Sex (male vs female) | 1.06 | 0.85-1.33 | .58 |
| MTD reached | 0.63 | 0.49-0.81 | .0004 |
| HbF ratio (per 10% increase) | 0.94 | 0.83-1.05 | .26 |
| Hb (per 1 g/dL increase) | 0.78 | 0.73-0.85 | <.0001 |
| ANC (per doubling) | 1.30 | 1.05-1.61 | .017 |
| MCV (per 10 fL increase) | 1.09 | 0.99-1.19 | .08 |
| Malaria season (vs low) | |||
| High | 1.11 | 0.76-1.62 | .58 |
| Moderate | 1.02 | 0.79-1.31 | .90 |
| Spleen status (vs nonpalpable) | |||
| Palpable (1-4 cm) | 2.05 | 1.44-2.94 | .0001 |
| Palpable (≥5 cm) | 1.45 | 0.91-2.29 | .12 |
| Splenectomy | 1.40 | 0.82-2.39 | .21 |
| α-Thalassemia (vs 4 genes) | |||
| 3 genes (−α3.7/αα) | 0.88 | 0.70-1.12 | .30 |
| 2 genes (−α3.7/−α3.7) | 0.69 | 0.49-0.96 | .026 |
| G6PD genotype (vs normal) | |||
| Male (hemizygous A-) | 1.09 | 0.76-1.56 | .64 |
| Female (heterozygous A) | 1.04 | 0.67-1.61 | .86 |
For HR calculations, the reference comparators were female sex, low malaria season, nonpalpable spleen, normal (4-gene) α-globin, and normal G6PD genotype of the same sex.