Table 2.

Risk factors for developing GVHD after orthotopic liver and intestinal transplantation

Orthotopic liver4,10,25-30 Intestinal and MV5,31,32 
Donor-recipient HLA matching Multivisceral or liver-included graft 
Recipient age >40 y Larger graft volume 
Donor-recipient age difference >20 y Transplant for MIAI 
Recipient glucose intolerance Retransplantation 
Recipient infection with CMV or HSV  
Transplant for AALD, HCC, or AILD  
Liver allograft with ≥6% steatosis  
Donor death from CVA  
Donor-recipient race mismatching  
Use of induction immunosuppression  
Orthotopic liver4,10,25-30 Intestinal and MV5,31,32 
Donor-recipient HLA matching Multivisceral or liver-included graft 
Recipient age >40 y Larger graft volume 
Donor-recipient age difference >20 y Transplant for MIAI 
Recipient glucose intolerance Retransplantation 
Recipient infection with CMV or HSV  
Transplant for AALD, HCC, or AILD  
Liver allograft with ≥6% steatosis  
Donor death from CVA  
Donor-recipient race mismatching  
Use of induction immunosuppression  

AALD, alcohol-associated liver disease; AILD, autoimmune liver disease; CVA, cerebrovascular accident; HCC, hepatocellular carcinoma; MIAI, multiple intestinal atresia and immunodeficiency; MV, multivisceral transplantation.

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