Comparison of survival outcomes of IDHmut vs IDHWT AML including by IDH isoform or mutation subtype in total cohort and by age group
| OS (n, 5-y estimated OS, 95% CI) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | IDHWT . | IDHmut . | P value . | IDH1mut . | IDH2mut . | P value . | IDH1R132 . | IDH2R140 . | IDH2R172K . | P value∗ . |
| Total | 2578, 55.4%, (53.3-57.3) | 221, 50.3%, (42.8-57.2) | .196 | 91, 50.6%, (38.9-61.2) | 130, 50.1%, (40.4-59.1) | .778 | 91, 50.6%, (38.9-61.2) | 110, 50.4%, (39.8-60.0) | 19, 45.6%, (20.0-68.1) | .939 |
| Pediatric | 1681, 63.2%, (60.8-65.6) | 60, 73.4%, (59.7-83.1) | .269 | 25, 78.7%, (56.1-90.6) | 35, 69.2%, (50.0-82.3) | .471 | 25, 78.7%, (56.1-90.6) | 34, 68.2%, (48.6-81.7) | 1, 100%, | .610 |
| AYA | 358, 52.0%, (46.3-57.3) | 44, 57.3%, (38.1-72.5) | .225 | 21, 58.3%, (27.7-79.7) | 23, 56.6%, (31.5-75.5) | .548 | 21, 58.3%, (27.7-79.7) | 17, 52.9%, (27.6-73.0) | 5, 66.7%, (5.4-94.5) | .312 |
| Intermediate age | 446, 34.4%, (29.7-39.1) | 92, 40.6%, (29.3-51.5) | .187 | 38, 33.8%, (18.2-50.1) | 54, 46.4%, (31.2-60.3) | .425 | 38, 33.8%, (18.2-50.1) | 43, 50.7%, (33.1-65.8) | 11, 32.7%, (8.3-60.6) | .479 |
| Older | 91, 19.8%, (12.3-28.7) | 25, 9.2%, (0.9-30.2) | .5 | 7, 14.3%, (0.7-46.5) | 18, 0% | .751 | 7, 14.3%, (0.7-46.5) | 16, 0% | 2, 50.0%, (0.6-91) | .692 |
| OS (n, 5-y estimated OS, 95% CI) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | IDHWT . | IDHmut . | P value . | IDH1mut . | IDH2mut . | P value . | IDH1R132 . | IDH2R140 . | IDH2R172K . | P value∗ . |
| Total | 2578, 55.4%, (53.3-57.3) | 221, 50.3%, (42.8-57.2) | .196 | 91, 50.6%, (38.9-61.2) | 130, 50.1%, (40.4-59.1) | .778 | 91, 50.6%, (38.9-61.2) | 110, 50.4%, (39.8-60.0) | 19, 45.6%, (20.0-68.1) | .939 |
| Pediatric | 1681, 63.2%, (60.8-65.6) | 60, 73.4%, (59.7-83.1) | .269 | 25, 78.7%, (56.1-90.6) | 35, 69.2%, (50.0-82.3) | .471 | 25, 78.7%, (56.1-90.6) | 34, 68.2%, (48.6-81.7) | 1, 100%, | .610 |
| AYA | 358, 52.0%, (46.3-57.3) | 44, 57.3%, (38.1-72.5) | .225 | 21, 58.3%, (27.7-79.7) | 23, 56.6%, (31.5-75.5) | .548 | 21, 58.3%, (27.7-79.7) | 17, 52.9%, (27.6-73.0) | 5, 66.7%, (5.4-94.5) | .312 |
| Intermediate age | 446, 34.4%, (29.7-39.1) | 92, 40.6%, (29.3-51.5) | .187 | 38, 33.8%, (18.2-50.1) | 54, 46.4%, (31.2-60.3) | .425 | 38, 33.8%, (18.2-50.1) | 43, 50.7%, (33.1-65.8) | 11, 32.7%, (8.3-60.6) | .479 |
| Older | 91, 19.8%, (12.3-28.7) | 25, 9.2%, (0.9-30.2) | .5 | 7, 14.3%, (0.7-46.5) | 18, 0% | .751 | 7, 14.3%, (0.7-46.5) | 16, 0% | 2, 50.0%, (0.6-91) | .692 |
| EFS (n, 5-y estimate EFS, 95% CI) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | IDHWT . | IDHmut . | P value . | IDH1mut . | IDH2mut . | P value . | IDH1R132 . | IDH2R140 . | IDH2R172K . | P value∗ . |
| Total | 2578, 40.0%, (38.1-42) | 221, 35.6%, (29.0-42.3) | .368 | 91, 35.8%, (25.7-46.0) | 130, 35.4%, (26.8-44.2) | .920 | 91, 35.8%, (25.7-46.0) | 110, 36.5%, (27.2-45.8) | 19, 12.4%, (5.8-50.1) | .892 |
| Pediatric | 1681, 45.6%, (43.2-48.0) | 60, 49.5%, (35.8-61.7) | .484 | 25, 57.6%, (35.4-74.6) | 35, 43.3%, (26.0-59.5) | .279 | 25, 57.6%, (35.4-74.6) | 34, 44.6%, (26.8-61.0) | 1, 0% | .342 |
| AYA | 358, 38.2%, (33.1-43.3) | 44, 52.6%, (36.3-66.6) | .061 | 21, 61.1%, (36.9-78.4) | 23, 46.4%, (25.0-65.4) | .473 | 21, 61.1%, (36.9-78.4) | 17, 40.3%, (17.6-62.2) | 5, 60.0%, (12.6-88.2) | .437 |
| Intermediate age | 446, 26.1%, (22-30.5) | 92, 24.2%, (15.3-34.3) | .980 | 38, 12.2%, (3.6-26.4) | 54, 33.4%, (20.5-46.9) | .086 | 38, 12.2%, (3.6-26.4) | 43, 39.3%, (24.5-53.8) | 11, 13.6%, (1.0-2.6) | .129 |
| Older | 91, 11.5%, (5.8-19.2) | 25, 13.7%, (3.6-30.6) | .293 | 7, 14.3%, (0.7-46.5) | 18, 13.3%, (2.3-34.0) | .636 | 7, 14.3%, (0.7-46.5) | 16, 7.8%, (0.5-29.1) | 2, 50.00%, (0.6-91.0) | .559 |
| EFS (n, 5-y estimate EFS, 95% CI) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | IDHWT . | IDHmut . | P value . | IDH1mut . | IDH2mut . | P value . | IDH1R132 . | IDH2R140 . | IDH2R172K . | P value∗ . |
| Total | 2578, 40.0%, (38.1-42) | 221, 35.6%, (29.0-42.3) | .368 | 91, 35.8%, (25.7-46.0) | 130, 35.4%, (26.8-44.2) | .920 | 91, 35.8%, (25.7-46.0) | 110, 36.5%, (27.2-45.8) | 19, 12.4%, (5.8-50.1) | .892 |
| Pediatric | 1681, 45.6%, (43.2-48.0) | 60, 49.5%, (35.8-61.7) | .484 | 25, 57.6%, (35.4-74.6) | 35, 43.3%, (26.0-59.5) | .279 | 25, 57.6%, (35.4-74.6) | 34, 44.6%, (26.8-61.0) | 1, 0% | .342 |
| AYA | 358, 38.2%, (33.1-43.3) | 44, 52.6%, (36.3-66.6) | .061 | 21, 61.1%, (36.9-78.4) | 23, 46.4%, (25.0-65.4) | .473 | 21, 61.1%, (36.9-78.4) | 17, 40.3%, (17.6-62.2) | 5, 60.0%, (12.6-88.2) | .437 |
| Intermediate age | 446, 26.1%, (22-30.5) | 92, 24.2%, (15.3-34.3) | .980 | 38, 12.2%, (3.6-26.4) | 54, 33.4%, (20.5-46.9) | .086 | 38, 12.2%, (3.6-26.4) | 43, 39.3%, (24.5-53.8) | 11, 13.6%, (1.0-2.6) | .129 |
| Older | 91, 11.5%, (5.8-19.2) | 25, 13.7%, (3.6-30.6) | .293 | 7, 14.3%, (0.7-46.5) | 18, 13.3%, (2.3-34.0) | .636 | 7, 14.3%, (0.7-46.5) | 16, 7.8%, (0.5-29.1) | 2, 50.00%, (0.6-91.0) | .559 |
Five-year estimates of OS and EFS, 95% CI. P values calculated by log-rank test.