Cox proportional hazards model for EFS and OS
| Characteristic . | Categories . | EFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | Univariate . | Multivariate . | ||||||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | ||
| Age groups | ≥75 vs 65-69 y | 1.37 | 1.07-1.74 | .011 | 1.41 | 1.10-1.82 | .007 | 1.25 | 0.96-1.62 | .105 | 1.2 | 0.91-1.58 | .188 |
| ≥75 vs 70-74 y | 1.54 | 1.19-1.98 | .001 | 1.46 | 1.13-1.89 | .004 | 1.29 | 0.98-1.70 | .066 | 1.2 | 0.90-1.58 | .207 | |
| Sex | Male vs female | 0.99 | 0.81-1.22 | .943 | 0.92 | 0.75-1.14 | .449 | 1.06 | 0.85-1.33 | .577 | 1 | 0.80-1.26 | .973 |
| Urban/suburban residence | Rural vs urban | 1.14 | 0.88-1.47 | .317 | — | — | 1.22 | 0.93-1.60 | .158 | — | — | ||
| Bridging therapy | Present vs absent | 1.34 | 1.09-1.64 | .005 | 1.27 | 1.03-1.56 | .028 | 1.49 | 1.19-1.86 | <.001 | 1.39 | 1.11-1.75 | .005 |
| Charlson Comorbidity Index | ≥5 vs 0-4 | 1.57 | 1.28-1.94 | <.0001 | 1.56 | 1.26–1.92 | <.0001 | 1.63 | 1.30-2.05 | <.0001 | 1.58 | 1.26-1.99 | <.0001 |
| Characteristic . | Categories . | EFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | Univariate . | Multivariate . | ||||||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | ||
| Age groups | ≥75 vs 65-69 y | 1.37 | 1.07-1.74 | .011 | 1.41 | 1.10-1.82 | .007 | 1.25 | 0.96-1.62 | .105 | 1.2 | 0.91-1.58 | .188 |
| ≥75 vs 70-74 y | 1.54 | 1.19-1.98 | .001 | 1.46 | 1.13-1.89 | .004 | 1.29 | 0.98-1.70 | .066 | 1.2 | 0.90-1.58 | .207 | |
| Sex | Male vs female | 0.99 | 0.81-1.22 | .943 | 0.92 | 0.75-1.14 | .449 | 1.06 | 0.85-1.33 | .577 | 1 | 0.80-1.26 | .973 |
| Urban/suburban residence | Rural vs urban | 1.14 | 0.88-1.47 | .317 | — | — | 1.22 | 0.93-1.60 | .158 | — | — | ||
| Bridging therapy | Present vs absent | 1.34 | 1.09-1.64 | .005 | 1.27 | 1.03-1.56 | .028 | 1.49 | 1.19-1.86 | <.001 | 1.39 | 1.11-1.75 | .005 |
| Charlson Comorbidity Index | ≥5 vs 0-4 | 1.57 | 1.28-1.94 | <.0001 | 1.56 | 1.26–1.92 | <.0001 | 1.63 | 1.30-2.05 | <.0001 | 1.58 | 1.26-1.99 | <.0001 |
—, this variable was not included in the multivariate analysis since it was not prognostic by univariate analysis. HR, hazard ratio.