Cox PHs (95% CI) for OS and PFS
| . | . | n . | sCD163 high . | P . | sCD163 continuously . | P . |
|---|---|---|---|---|---|---|
| OS | a | 131 | 3.79 (1.91-7.48) | <.001 | 1.04 (1.02-1.06) | <.001 |
| b | 131 | 4.10 (2.06-8.16) | <.001 | 1.04 (1.02-1.06) | <.001 | |
| c | 57 | 4.33 (1.32-14.2) | .016 | 1.04 (0.996-1.08) | .075 | |
| PFS | a | 131 | 2.73 (1.16-4.62) | <.001 | 1.04 (1.02-1.05) | <.001 |
| b | 131 | 3.13 (1.83-5.36) | <.001 | 1.04 (1.02-1.05) | <.001 | |
| c | 57 | 3.48 (1.42-8.54) | .006 | 1.04 (1.003-1.07) | .034 |
| . | . | n . | sCD163 high . | P . | sCD163 continuously . | P . |
|---|---|---|---|---|---|---|
| OS | a | 131 | 3.79 (1.91-7.48) | <.001 | 1.04 (1.02-1.06) | <.001 |
| b | 131 | 4.10 (2.06-8.16) | <.001 | 1.04 (1.02-1.06) | <.001 | |
| c | 57 | 4.33 (1.32-14.2) | .016 | 1.04 (0.996-1.08) | .075 | |
| PFS | a | 131 | 2.73 (1.16-4.62) | <.001 | 1.04 (1.02-1.05) | <.001 |
| b | 131 | 3.13 (1.83-5.36) | <.001 | 1.04 (1.02-1.05) | <.001 | |
| c | 57 | 3.48 (1.42-8.54) | .006 | 1.04 (1.003-1.07) | .034 |
The prognostic value of sCD163 is shown dichotomized at median level of sCD163 (3112 ng/mL) and as a continuous variable at intervals of 100 ng/mL. The model is stratified by time of sampling (at diagnosis or at relapse) and adjusted for: (a) univariable (b) age ≥ 70 years, sex. (c) MIPI, Ki-67 ≥30%, blastoid histology and presence of p53 overexpression or TP53 mutation. Model (c) is based on the population-based cohort from Uppsala and the clinical study cohort.
Boldface indicates statistically significant values.
MIPI, mantle cell lymphoma international prognostic index.