Grade 3/4 metabolic toxicities during different phases of treatment
| Grade 3/4 toxicity . | Induction phase . | Consolidation phase . | Maintenance/ posttreatment phase . | Overall . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal, % . | Overweight/obese, % . | P∗ value . | Normal, % . | Overweight/obese, % . | P∗ value . | Normal, % . | Overweight/obese, % . | P value . | Normal, % . | Overweight/obese, % . | P value . | |
| Elevated AST | 6.0 | 10.4 | .14 | 9.9 | 19.3 | .023 | 5.5 | 9.5 | .23 | 14.4 | 26.6 | .005 |
| Elevated ALT | 13.7 | 22.1 | .046 | 29.1 | 37.9 | .12 | 19.5 | 24.1 | .38 | 38.9 | 50.3 | .031 |
| Elevated bilirubin | 4.2 | 14.7 | .001 | 3.3 | 11.4 | .011 | 0 | 2.6 | .11 | 6.7 | 23.1 | <.0001 |
| Elevated TG | 1.2 | 6.1 | .019 | 27.8 | 32.1 | .42 | 0 | 4.3 | .023 | 24.4 | 29.5 | .29 |
| Elevated glucose | 18.5 | 28.8 | .026 | 12.6 | 20.7 | .06 | 2.3 | 8.6 | .028 | 24.4 | 36.4 | .014 |
| Grade 3/4 toxicity . | Induction phase . | Consolidation phase . | Maintenance/ posttreatment phase . | Overall . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal, % . | Overweight/obese, % . | P∗ value . | Normal, % . | Overweight/obese, % . | P∗ value . | Normal, % . | Overweight/obese, % . | P value . | Normal, % . | Overweight/obese, % . | P value . | |
| Elevated AST | 6.0 | 10.4 | .14 | 9.9 | 19.3 | .023 | 5.5 | 9.5 | .23 | 14.4 | 26.6 | .005 |
| Elevated ALT | 13.7 | 22.1 | .046 | 29.1 | 37.9 | .12 | 19.5 | 24.1 | .38 | 38.9 | 50.3 | .031 |
| Elevated bilirubin | 4.2 | 14.7 | .001 | 3.3 | 11.4 | .011 | 0 | 2.6 | .11 | 6.7 | 23.1 | <.0001 |
| Elevated TG | 1.2 | 6.1 | .019 | 27.8 | 32.1 | .42 | 0 | 4.3 | .023 | 24.4 | 29.5 | .29 |
| Elevated glucose | 18.5 | 28.8 | .026 | 12.6 | 20.7 | .06 | 2.3 | 8.6 | .028 | 24.4 | 36.4 | .014 |
TG, triglycerides.
Fisher exact test used.