Summary of TP53-alteration frequencies and OS
| . | Total cohort (N = 1519) . | MDS with <5% blasts (n = 419) . | MDS with ≥5% but <10% blasts (n = 175) . | MDS with ≥10% but <20% blasts (n = 153) . | AML (n = 772) . |
|---|---|---|---|---|---|
| Numbers and frequencies of TP53 alterations | |||||
| Cases with TP53 alteration | 12%, 178 of 1519 | 11%, 45 of 419 | 15%, 27 of 175 | 15%, 23 of 153 | 11%, 83 of 772 |
| TP53 single hit | 39%, 69 of 178 | 76%, 34 of 45 | 33%, 9 of 27 | 9%, 2 of 23 | 29%, 24 of 83 |
| TP53 double hit | 61%, 109 of 178 | 24%, 11 of 45 | 67%, 18 of 27 | 91%, 21 of 23 | 71%, 59 of 83 |
| Frequency of complex karyotype | |||||
| TP53 single hit | 17%, 12 of 69 | 6%, 2 of 34 | 22%, 2 of 9 | 50%, 1 of 2 | 29%, 7 of 24 |
| TP53 double hit | 84%, 92 of 109 | 82%, 9 of 11 | 94%, 17 of 18 | 95%, 20 of 21 | 78%, 46 of 59 |
| OS (mo, median) | |||||
| Total respective cohort | 46 | 75 | 54 | 27 | 18 |
| Cases without TP53 alteration | 54 | 80 | 60 | 34 | 21 |
| Cases with TP53 alteration | 11 | 56 | 11 | 10 | 3 |
| TP53 single hit | 39 | 57 | 22 | 14 | 8 |
| TP53 double hit | 4 | 17 | 10 | 8 | 1 |
| . | Total cohort (N = 1519) . | MDS with <5% blasts (n = 419) . | MDS with ≥5% but <10% blasts (n = 175) . | MDS with ≥10% but <20% blasts (n = 153) . | AML (n = 772) . |
|---|---|---|---|---|---|
| Numbers and frequencies of TP53 alterations | |||||
| Cases with TP53 alteration | 12%, 178 of 1519 | 11%, 45 of 419 | 15%, 27 of 175 | 15%, 23 of 153 | 11%, 83 of 772 |
| TP53 single hit | 39%, 69 of 178 | 76%, 34 of 45 | 33%, 9 of 27 | 9%, 2 of 23 | 29%, 24 of 83 |
| TP53 double hit | 61%, 109 of 178 | 24%, 11 of 45 | 67%, 18 of 27 | 91%, 21 of 23 | 71%, 59 of 83 |
| Frequency of complex karyotype | |||||
| TP53 single hit | 17%, 12 of 69 | 6%, 2 of 34 | 22%, 2 of 9 | 50%, 1 of 2 | 29%, 7 of 24 |
| TP53 double hit | 84%, 92 of 109 | 82%, 9 of 11 | 94%, 17 of 18 | 95%, 20 of 21 | 78%, 46 of 59 |
| OS (mo, median) | |||||
| Total respective cohort | 46 | 75 | 54 | 27 | 18 |
| Cases without TP53 alteration | 54 | 80 | 60 | 34 | 21 |
| Cases with TP53 alteration | 11 | 56 | 11 | 10 | 3 |
| TP53 single hit | 39 | 57 | 22 | 14 | 8 |
| TP53 double hit | 4 | 17 | 10 | 8 | 1 |
| . | Without TP53 alteration . | TP53 single hit . | TP53 double hit . | ||
|---|---|---|---|---|---|
| OS (mo, median) | |||||
| Total respective cohort | 54 | 39 | 4 | ||
| Without complex karyotype | 55 | 46 | 2 | ||
| With complex karyotype | 24 | 14 | 4 | ||
| <5% blasts | 80 | 57 | 17 | ||
| ≥5% blasts | 33 | 20 | 4 | ||
| . | Without TP53 alteration . | TP53 single hit . | TP53 double hit . | ||
|---|---|---|---|---|---|
| OS (mo, median) | |||||
| Total respective cohort | 54 | 39 | 4 | ||
| Without complex karyotype | 55 | 46 | 2 | ||
| With complex karyotype | 24 | 14 | 4 | ||
| <5% blasts | 80 | 57 | 17 | ||
| ≥5% blasts | 33 | 20 | 4 | ||