Characteristics of 85 patients who developed lymphoid neoplasms after ALL diagnosis, without prior HSCT
| Characteristic . | Total∗ (n = 85) . | LBL (n = 22) . | Mature B-cell lymphoproliferations (n = 56) . | P value†: Mature B vs LBL . |
|---|---|---|---|---|
| Sex, n (%) | ||||
| Male | 52 (61) | 14 (64) | 33 (59) | .79 |
| Female | 33 (39) | 8 (36) | 23 (41) | |
| Age at ALL diagnosis, n (%) | ||||
| <10 years | 67 (79) | 20 (91) | 43 (77) | .21 |
| ≥10 years | 18 (21) | 2 (9) | 13 (23) | |
| Age at lymphoid neoplasm diagnosis, n (%) | ||||
| <10 years | 49 (58) | 11 (50) | 35 (63) | .32 |
| ≥10 years | 36 (42) | 11 (50) | 21 (37) | |
| Leukemia lineage, n (%) | ||||
| B-ALL | 64 (75) | 16 (73) | 44 (79) | .12 |
| T-ALL | 12 (14) | 5 (23) | 5 (9) | |
| Unknown | 9 (11) | 1 (4) | 7 (12) | |
| Interval between leukemia and lymphoid neoplasm diagnoses, years | ||||
| Median (IQR) | 2.28 (1.58-4.01) | 3.7 (2.18-9.35) | 2.2 (1.45-2.96) | <.01 |
| Lymphoid neoplasm diagnosed during maintenance or within 6 months of its completion, n (%) | 59 (69) | 8 (36) | 46 (82) | <.01 |
| Lymphoid neoplasm diagnosed >6 months of maintenance cessation, n (%) | 26 (31) | 14 (64) | 10 (18) |
| Characteristic . | Total∗ (n = 85) . | LBL (n = 22) . | Mature B-cell lymphoproliferations (n = 56) . | P value†: Mature B vs LBL . |
|---|---|---|---|---|
| Sex, n (%) | ||||
| Male | 52 (61) | 14 (64) | 33 (59) | .79 |
| Female | 33 (39) | 8 (36) | 23 (41) | |
| Age at ALL diagnosis, n (%) | ||||
| <10 years | 67 (79) | 20 (91) | 43 (77) | .21 |
| ≥10 years | 18 (21) | 2 (9) | 13 (23) | |
| Age at lymphoid neoplasm diagnosis, n (%) | ||||
| <10 years | 49 (58) | 11 (50) | 35 (63) | .32 |
| ≥10 years | 36 (42) | 11 (50) | 21 (37) | |
| Leukemia lineage, n (%) | ||||
| B-ALL | 64 (75) | 16 (73) | 44 (79) | .12 |
| T-ALL | 12 (14) | 5 (23) | 5 (9) | |
| Unknown | 9 (11) | 1 (4) | 7 (12) | |
| Interval between leukemia and lymphoid neoplasm diagnoses, years | ||||
| Median (IQR) | 2.28 (1.58-4.01) | 3.7 (2.18-9.35) | 2.2 (1.45-2.96) | <.01 |
| Lymphoid neoplasm diagnosed during maintenance or within 6 months of its completion, n (%) | 59 (69) | 8 (36) | 46 (82) | <.01 |
| Lymphoid neoplasm diagnosed >6 months of maintenance cessation, n (%) | 26 (31) | 14 (64) | 10 (18) |
Data from the Ponte di Legno Childhood ALL Working Group study.
IQR, interquartile range.
The total number of patients includes patients with LBL (n = 22) and mature B-cell lymphoproliferations (n = 56) in addition to patients with peripheral T-cell lymphoma (n = 2) and NHL with no further classification (n = 5), as described in more detail in “Results”.
Fisher exact test or Brown-Mood median test.