Baseline characteristics of MPN cases and matched controls
| Variable . | Cases, N = 10 336 (%) . | Controls, N = 41 344 (%) . | Standardized difference∗ . | P value† . |
|---|---|---|---|---|
| Age (y) | <0.001 | >.9 | ||
| Mean (SD) | 66.0 (16.0) | 66.07 (16.0) | ||
| Median (IQR) | 68.0 (56.0-78.0) | 68.0 (56.0-78.0) | ||
| Age (y) (categorical) | 0.002 | >.9 | ||
| Less than 40 y | 735 (7.1) | 2950 (7.1) | ||
| 40-64 y | 3553 (34) | 14 234 (34) | ||
| 65-74 y | 2478 (24) | 9907 (24) | ||
| 75 y or older | 3570 (35) | 14 253 (34) | ||
| Sex | 0 | >.9 | ||
| Female | 5479 (53) | 21 916 (53) | ||
| Type of MPN | NA | |||
| ET | 5108 (49) | NA | ||
| PV | 3843 (37) | NA | ||
| MF | 1385 (13) | NA | ||
| Prior thrombosis | 1230 (12) | 1897 (4.6) | 0.268 | <.001 |
| Y of diagnosis | NA | |||
| 2004-2009 | 868 (8) | NA | ||
| 2010-2015 | 5065 (49) | NA | ||
| 2016-2019 | 4403 (42) | NA | ||
| Residence | 0.007 | .5 | ||
| Rural | 1262 (12) | 5142 (12) | ||
| Urban | 9074 (88) | 36 202 (88) | ||
| Income quintile | 0 | >.9 | ||
| Q1 | 2209 (21) | 8836 (21) | ||
| Q2 | 2058 (20) | 8232 (20) | ||
| Q3 | 2013 (20) | 8052 (20) | ||
| Q4 | 1952 (19) | 7808 (19) | ||
| Q5 | 2061 (20) | 8244 (20) | ||
| (Missing) | 43 | 172 | ||
| Instability | 0.027 | .2 | ||
| Q1 (lowest) | 1671 (16) | 6902 (17) | ||
| Q2 | 1804 (18) | 7334 (18) | ||
| Q3 | 1908 (19) | 7678 (19) | ||
| Q4 | 1997 (20) | 8104 (20) | ||
| Q5 (highest) | 2857 (28) | 10 956 (27) | ||
| (Missing) | 99 | 370 | ||
| Dependency | 0.026 | .2 | ||
| Q1 (lowest) | 1835 (18) | 7418 (18) | ||
| Q2 | 1783 (17) | 7375 (18) | ||
| Q3 | 1855 (18) | 7180 (18) | ||
| Q4 | 1992 (19) | 7727 (19) | ||
| Q5 (highest) | 2772 (27) | 11 274 (28) | ||
| (Missing) | 99 | 370 | ||
| Deprivation | 0.017 | .6 | ||
| Q1 (lowest) | 2056 (20) | 8080 (20) | ||
| Q2 | 2025 (20) | 8211 (20) | ||
| Q3 | 1990 (19) | 7992 (20) | ||
| Q4 | 2026 (20) | 8303 (20) | ||
| Q5 (highest) | 2439 (24) | 9930 (24) | ||
| Ethnic concentration | ||||
| Q1 (lowest) | 2000 (19.3) | 7983 (19.3) | 0.019 | .5 |
| Q2 | 1812 (17.5) | 7479 (18.1) | ||
| Q3 | 1924 (18.6) | 7562 (18.3) | ||
| Q4 | 2062 (19.9) | 8020 (19.4) | ||
| Q5 (highest) | 2439 (23.6) | 9930 (24.0) | ||
| (Missing) | 99 | 370 |
| Variable . | Cases, N = 10 336 (%) . | Controls, N = 41 344 (%) . | Standardized difference∗ . | P value† . |
|---|---|---|---|---|
| Age (y) | <0.001 | >.9 | ||
| Mean (SD) | 66.0 (16.0) | 66.07 (16.0) | ||
| Median (IQR) | 68.0 (56.0-78.0) | 68.0 (56.0-78.0) | ||
| Age (y) (categorical) | 0.002 | >.9 | ||
| Less than 40 y | 735 (7.1) | 2950 (7.1) | ||
| 40-64 y | 3553 (34) | 14 234 (34) | ||
| 65-74 y | 2478 (24) | 9907 (24) | ||
| 75 y or older | 3570 (35) | 14 253 (34) | ||
| Sex | 0 | >.9 | ||
| Female | 5479 (53) | 21 916 (53) | ||
| Type of MPN | NA | |||
| ET | 5108 (49) | NA | ||
| PV | 3843 (37) | NA | ||
| MF | 1385 (13) | NA | ||
| Prior thrombosis | 1230 (12) | 1897 (4.6) | 0.268 | <.001 |
| Y of diagnosis | NA | |||
| 2004-2009 | 868 (8) | NA | ||
| 2010-2015 | 5065 (49) | NA | ||
| 2016-2019 | 4403 (42) | NA | ||
| Residence | 0.007 | .5 | ||
| Rural | 1262 (12) | 5142 (12) | ||
| Urban | 9074 (88) | 36 202 (88) | ||
| Income quintile | 0 | >.9 | ||
| Q1 | 2209 (21) | 8836 (21) | ||
| Q2 | 2058 (20) | 8232 (20) | ||
| Q3 | 2013 (20) | 8052 (20) | ||
| Q4 | 1952 (19) | 7808 (19) | ||
| Q5 | 2061 (20) | 8244 (20) | ||
| (Missing) | 43 | 172 | ||
| Instability | 0.027 | .2 | ||
| Q1 (lowest) | 1671 (16) | 6902 (17) | ||
| Q2 | 1804 (18) | 7334 (18) | ||
| Q3 | 1908 (19) | 7678 (19) | ||
| Q4 | 1997 (20) | 8104 (20) | ||
| Q5 (highest) | 2857 (28) | 10 956 (27) | ||
| (Missing) | 99 | 370 | ||
| Dependency | 0.026 | .2 | ||
| Q1 (lowest) | 1835 (18) | 7418 (18) | ||
| Q2 | 1783 (17) | 7375 (18) | ||
| Q3 | 1855 (18) | 7180 (18) | ||
| Q4 | 1992 (19) | 7727 (19) | ||
| Q5 (highest) | 2772 (27) | 11 274 (28) | ||
| (Missing) | 99 | 370 | ||
| Deprivation | 0.017 | .6 | ||
| Q1 (lowest) | 2056 (20) | 8080 (20) | ||
| Q2 | 2025 (20) | 8211 (20) | ||
| Q3 | 1990 (19) | 7992 (20) | ||
| Q4 | 2026 (20) | 8303 (20) | ||
| Q5 (highest) | 2439 (24) | 9930 (24) | ||
| Ethnic concentration | ||||
| Q1 (lowest) | 2000 (19.3) | 7983 (19.3) | 0.019 | .5 |
| Q2 | 1812 (17.5) | 7479 (18.1) | ||
| Q3 | 1924 (18.6) | 7562 (18.3) | ||
| Q4 | 2062 (19.9) | 8020 (19.4) | ||
| Q5 (highest) | 2439 (23.6) | 9930 (24.0) | ||
| (Missing) | 99 | 370 |