Regression: anti-FVIII antibody levels in individuals with a current inhibitor exposed or not exposed to haplotype-mismatched FVIII
| Comparison∗ . | Variable . | Ratio . | P value . |
|---|---|---|---|
| Individuals with severe HA H1 haplotype mismatched (n = 8) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 0.807 | .712 |
| FL-FVIII-H2 | 0.87 | .795 | |
| BDD-FVIII-H1H2 | 0.78 | .313 | |
| BDD-FVIII-H3 | 0.76 | .092 | |
| BDD-FVIII-H4 | 0.778 | .301 | |
| FVIII protein average | 0.798 | .502 | |
| Individuals with severe HA H2 haplotype mismatched (n = 7) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 0.74 | .81 |
| FL-FVIII-H2 | 0.84 | .885 | |
| BDD-FVIII-H1H2 | 1.416 | .714 | |
| BDD-FVIII-H3 | 1.404 | .698 | |
| BDD-FVIII-H4 | 1.479 | .671 | |
| FVIII protein average | 1.128 | .906 | |
| Individuals with severe HA H3 + H5 (all haplotype mismatched) (n = 2) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 1.106 | .953 |
| FL-FVIII-H2 | 0.861 | .927 | |
| BDD-FVIII-H1H2 | 1.054 | .911 | |
| BDD-FVIII-H3 | 0.903 | .835 | |
| BDD-FVIII-H4 | 0.725 | .222 | |
| FVIII protein average | 0.92 | .925 | |
| Individuals with mild + moderate HA H1 haplotype mismatched (n = 1) vs those with mild + moderate HA not haplotype mismatched (n = 1) | FL-FVIII-H1 | - | - |
| FL-FVIII-H2 | - | - | |
| BDD-FVIII-H1H2 | - | - | |
| BDD-FVIII-H3 | - | - | |
| BDD-FVIII-H4 | - | - | |
| FVIII protein average | - | - | |
| Individuals with mild + moderate HA H2 haplotype mismatched (n = 1) vs those with mild + moderate HA not haplotype mismatched (n = 1) | FL-FVIII-H1 | - | - |
| FL-FVIII-H2 | - | - | |
| BDD-FVIII-H1H2 | - | - | |
| BDD-FVIII-H3 | - | - | |
| BDD-FVIII-H4 | - | - | |
| Protein average | - | - | |
| Black individuals with severe HA (H3 + H5) (n = 2) vs Black individuals with severe HA (H1 + H2) (n = 10) | FL-FVIII-H1 | 0.32 | .236 |
| FL-FVIII-H2 | 0.283 | .172 | |
| BDD-FVIII-H1H2 | 0.681 | .633 | |
| BDD-FVIII-H3 | 0.744 | .691 | |
| BDD-FVIII-H4 | 0.65 | .593 | |
| Protein average | 0.495 | .374 |
| Comparison∗ . | Variable . | Ratio . | P value . |
|---|---|---|---|
| Individuals with severe HA H1 haplotype mismatched (n = 8) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 0.807 | .712 |
| FL-FVIII-H2 | 0.87 | .795 | |
| BDD-FVIII-H1H2 | 0.78 | .313 | |
| BDD-FVIII-H3 | 0.76 | .092 | |
| BDD-FVIII-H4 | 0.778 | .301 | |
| FVIII protein average | 0.798 | .502 | |
| Individuals with severe HA H2 haplotype mismatched (n = 7) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 0.74 | .81 |
| FL-FVIII-H2 | 0.84 | .885 | |
| BDD-FVIII-H1H2 | 1.416 | .714 | |
| BDD-FVIII-H3 | 1.404 | .698 | |
| BDD-FVIII-H4 | 1.479 | .671 | |
| FVIII protein average | 1.128 | .906 | |
| Individuals with severe HA H3 + H5 (all haplotype mismatched) (n = 2) vs those with severe HA not haplotype mismatched (n = 4) | FL-FVIII-H1 | 1.106 | .953 |
| FL-FVIII-H2 | 0.861 | .927 | |
| BDD-FVIII-H1H2 | 1.054 | .911 | |
| BDD-FVIII-H3 | 0.903 | .835 | |
| BDD-FVIII-H4 | 0.725 | .222 | |
| FVIII protein average | 0.92 | .925 | |
| Individuals with mild + moderate HA H1 haplotype mismatched (n = 1) vs those with mild + moderate HA not haplotype mismatched (n = 1) | FL-FVIII-H1 | - | - |
| FL-FVIII-H2 | - | - | |
| BDD-FVIII-H1H2 | - | - | |
| BDD-FVIII-H3 | - | - | |
| BDD-FVIII-H4 | - | - | |
| FVIII protein average | - | - | |
| Individuals with mild + moderate HA H2 haplotype mismatched (n = 1) vs those with mild + moderate HA not haplotype mismatched (n = 1) | FL-FVIII-H1 | - | - |
| FL-FVIII-H2 | - | - | |
| BDD-FVIII-H1H2 | - | - | |
| BDD-FVIII-H3 | - | - | |
| BDD-FVIII-H4 | - | - | |
| Protein average | - | - | |
| Black individuals with severe HA (H3 + H5) (n = 2) vs Black individuals with severe HA (H1 + H2) (n = 10) | FL-FVIII-H1 | 0.32 | .236 |
| FL-FVIII-H2 | 0.283 | .172 | |
| BDD-FVIII-H1H2 | 0.681 | .633 | |
| BDD-FVIII-H3 | 0.744 | .691 | |
| BDD-FVIII-H4 | 0.65 | .593 | |
| Protein average | 0.495 | .374 |
Adjusted for age, and whether the individuals with HA were related to any other individuals with HA. Models in which the primary comparison did not involve race were adjusted for race.