Regression: anti-FVIII antibody levels in individuals with no current inhibitor exposed vs not exposed to haplotype-mismatched FVIII
| Comparison∗ . | Variable . | Not adjusted for inhibitor history . | Adjusted for inhibitor history . | ||
|---|---|---|---|---|---|
| Ratio . | P value . | Ratio . | P value . | ||
| Individuals with severe HA with H1 haplotype mismatched (n = 142) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 0.775 | .088 | 0.757 | .063 |
| FL-FVIII-H2 | 0.875 | .342 | 0.853 | .256 | |
| BDD-FVIII-H1H2 | 0.924 | .486 | 0.91 | .41 | |
| BDD-FVIII-H3 | 0.977 | .813 | 0.965 | .717 | |
| BDD-FVIII-H4 | 0.952 | .636 | 0.936 | .525 | |
| FVIII protein average | 0.886 | .241 | 0.867 | .168 | |
| Individuals with severe HA with H2 haplotype mismatched (n = 79) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 1.125 | .34 | 1.075 | .547 |
| FL-FVIII-H2 | 1.133 | .468 | 1.087 | .623 | |
| BDD-FVIII-H1H2 | 1.179 | .156 | 1.129 | .278 | |
| BDD-FVIII-H3 | 1.023 | .9 | 0.977 | .897 | |
| BDD-FVIII-H4 | 1.125 | .364 | 1.07 | .589 | |
| FVIII protein average | 1.124 | .345 | 1.074 | .55 | |
| Individuals with severe HA with H3 + H5 (all haplotype mismatched) (n = 27) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 1.029 | .915 | 1.008 | .975 |
| FL-FVIII-H2 | 0.938 | .8 | 0.918 | .736 | |
| BDD-FVIII-H1H2 | 0.961 | .825 | 0.926 | .667 | |
| BDD-FVIII-H3 | 0.899 | .574 | 0.859 | .411 | |
| BDD-FVIII-H4 | 0.87 | .465 | 0.835 | .335 | |
| FVIII protein average | 0.938 | .714 | 0.907 | .574 | |
| Individuals with mild + moderate HA H1 haplotype mismatched (n = 11) vs those with mild + moderate HA not haplotype mismatched (n = 8) | FL-FVIII-H1 | 0.873 | .756 | 0.996 | .993 |
| FL-FVIII-H2 | 1.069 | .883 | 1.175 | .733 | |
| BDD-FVIII-H1H2 | 0.654 | .214 | 0.644 | .225 | |
| BDD-FVIII-H3 | 0.749 | .349 | 0.716 | .305 | |
| BDD-FVIII-H4 | 0.736 | .321 | 0.7 | .272 | |
| FVIII protein average | 0.804 | .503 | 0.823 | .571 | |
| Individuals with mild + moderate HA H2 haplotype mismatched (n = 13) vs mild + moderate HA not haplotype mismatched (n = 8) | FL-FVIII-H1 | 1.169 | .776 | 1.664 | .299 |
| FL-FVIII-H2 | 1.274 | .638 | 1.759 | .23 | |
| BDD-FVIII-H1H2 | 0.708 | .289 | 0.816 | .524 | |
| BDD-FVIII-H3 | 0.672 | .238 | 0.807 | .49 | |
| BDD-FVIII-H4 | 0.681 | .216 | 0.8 | .442 | |
| Protein average | 0.864 | .686 | 1.091 | .785 | |
| Black individuals with severe HA (H3 + H5) (n = 26) vs Black individuals with severe HA Black (H1 + H2) (n = 121) | FL-FVIII-H1 | 0.837 | .426 | 0.816 | .387 |
| FL-FVIII-H2 | 0.88 | .535 | 0.915 | .682 | |
| BDD-FVIII-H3 | 0.75 | .039 | 0.773 | .073 | |
| BDD-FVIII-H1H2 | 0.708 | .021 | 0.748 | .06 | |
| BDD-FVIII-H4 | 0.719 | .022 | 0.749 | .051 | |
| Protein average | 0.762 | .061 | 0.763 | .062 | |
| Comparison∗ . | Variable . | Not adjusted for inhibitor history . | Adjusted for inhibitor history . | ||
|---|---|---|---|---|---|
| Ratio . | P value . | Ratio . | P value . | ||
| Individuals with severe HA with H1 haplotype mismatched (n = 142) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 0.775 | .088 | 0.757 | .063 |
| FL-FVIII-H2 | 0.875 | .342 | 0.853 | .256 | |
| BDD-FVIII-H1H2 | 0.924 | .486 | 0.91 | .41 | |
| BDD-FVIII-H3 | 0.977 | .813 | 0.965 | .717 | |
| BDD-FVIII-H4 | 0.952 | .636 | 0.936 | .525 | |
| FVIII protein average | 0.886 | .241 | 0.867 | .168 | |
| Individuals with severe HA with H2 haplotype mismatched (n = 79) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 1.125 | .34 | 1.075 | .547 |
| FL-FVIII-H2 | 1.133 | .468 | 1.087 | .623 | |
| BDD-FVIII-H1H2 | 1.179 | .156 | 1.129 | .278 | |
| BDD-FVIII-H3 | 1.023 | .9 | 0.977 | .897 | |
| BDD-FVIII-H4 | 1.125 | .364 | 1.07 | .589 | |
| FVIII protein average | 1.124 | .345 | 1.074 | .55 | |
| Individuals with severe HA with H3 + H5 (all haplotype mismatched) (n = 27) vs those with severe HA not haplotype mismatched (n = 70) | FL-FVIII-H1 | 1.029 | .915 | 1.008 | .975 |
| FL-FVIII-H2 | 0.938 | .8 | 0.918 | .736 | |
| BDD-FVIII-H1H2 | 0.961 | .825 | 0.926 | .667 | |
| BDD-FVIII-H3 | 0.899 | .574 | 0.859 | .411 | |
| BDD-FVIII-H4 | 0.87 | .465 | 0.835 | .335 | |
| FVIII protein average | 0.938 | .714 | 0.907 | .574 | |
| Individuals with mild + moderate HA H1 haplotype mismatched (n = 11) vs those with mild + moderate HA not haplotype mismatched (n = 8) | FL-FVIII-H1 | 0.873 | .756 | 0.996 | .993 |
| FL-FVIII-H2 | 1.069 | .883 | 1.175 | .733 | |
| BDD-FVIII-H1H2 | 0.654 | .214 | 0.644 | .225 | |
| BDD-FVIII-H3 | 0.749 | .349 | 0.716 | .305 | |
| BDD-FVIII-H4 | 0.736 | .321 | 0.7 | .272 | |
| FVIII protein average | 0.804 | .503 | 0.823 | .571 | |
| Individuals with mild + moderate HA H2 haplotype mismatched (n = 13) vs mild + moderate HA not haplotype mismatched (n = 8) | FL-FVIII-H1 | 1.169 | .776 | 1.664 | .299 |
| FL-FVIII-H2 | 1.274 | .638 | 1.759 | .23 | |
| BDD-FVIII-H1H2 | 0.708 | .289 | 0.816 | .524 | |
| BDD-FVIII-H3 | 0.672 | .238 | 0.807 | .49 | |
| BDD-FVIII-H4 | 0.681 | .216 | 0.8 | .442 | |
| Protein average | 0.864 | .686 | 1.091 | .785 | |
| Black individuals with severe HA (H3 + H5) (n = 26) vs Black individuals with severe HA Black (H1 + H2) (n = 121) | FL-FVIII-H1 | 0.837 | .426 | 0.816 | .387 |
| FL-FVIII-H2 | 0.88 | .535 | 0.915 | .682 | |
| BDD-FVIII-H3 | 0.75 | .039 | 0.773 | .073 | |
| BDD-FVIII-H1H2 | 0.708 | .021 | 0.748 | .06 | |
| BDD-FVIII-H4 | 0.719 | .022 | 0.749 | .051 | |
| Protein average | 0.762 | .061 | 0.763 | .062 | |
P values <0.05 are set in bold.
Adjusted for age, and whether the individuals with HA were related to any other individuals with HA. Models in which the primary comparison did not involve race were adjusted for race.