Regression: anti-FVIII antibody levels in subgroups with no current inhibitor
| Comparison∗ . | Variable . | Not adjusted for inhibitor history . | Adjusted for inhibitor history . | ||
|---|---|---|---|---|---|
| Ratio . | P value . | Ratio . | P value . | ||
| Individuals (n = 323) with severe HA vs family controls (n = 23) | FL-FVIII-H1 | 1.93 | .008 | 1.824 | .016 |
| FL-FVIII-H2 | 1.73 | .018 | 1.62 | .039 | |
| BDD-FVIII-H1H2 | 1.422 | .052 | 1.332 | .117 | |
| BDD-FVIII-H3 | 1.462 | .019 | 1.388 | .045 | |
| BDD-FVIII-H4 | 1.489 | .019 | 1.401 | .049 | |
| FVIII protein average | 1.594 | .005 | 1.499 | .017 | |
| Individuals with severe HA (n = 323) vs those with mild + moderate HA (n = 43) | FL-FVIII-H1 | 1.323 | .089 | 1.324 | .086 |
| FL-FVIII-H2 | 1.221 | .2 | 1.222 | .196 | |
| BDD-FVIII-H1H2 | 0.977 | .848 | 0.978 | .851 | |
| BDD-FVIII-H3 | 0.955 | .669 | 0.956 | .671 | |
| BDD-FVIII-H4 | 0.935 | .544 | 0.935 | .544 | |
| FVIII protein average | 1.07 | .546 | 1.07 | .543 | |
| Individuals with mild + moderate HA (n = 43) vs family controls (n = 23) | FL-FVIII-H1 | 0.793 | .59 | 0.797 | .577 |
| FL-FVIII-H2 | 1.038 | .929 | 1.042 | .918 | |
| BDD-FVIII-H1H2 | 1.105 | .741 | 1.107 | .735 | |
| BDD-FVIII-H3 | 1.054 | .859 | 1.056 | .851 | |
| BDD-FVIII-H4 | 1.329 | .332 | 1.331 | .327 | |
| FVIII protein average | 1.05 | .871 | 1.052 | .859 | |
| Individuals with severe HA with intron-22 inversion (n = 124) vs those with severe HA without intron-22 inversion (n = 165) | FL-FVIII-H1 | 0.894 | .362 | 0.878 | .29 |
| FL-FVIII-H2 | 0.906 | .398 | 0.893 | .333 | |
| BDD-FVIII-H1H2 | 1.06 | .524 | 1.045 | .631 | |
| BDD-FVIII-H3 | 0.992 | .921 | 0.98 | .798 | |
| BDD-FVIII-H4 | 1.007 | .936 | 0.991 | .919 | |
| FVIII protein average | 0.962 | .648 | 0.947 | .526 | |
| Individuals with severe HA treated with BDD-FVIII (n = 34) vs those with severe HA not treated with BDD-FVIII (n = 229) | FL-FVIII-H1 | 1.531 | .022 | 1.53 | .023 |
| FL-FVIII-H2 | 1.333 | .105 | 1.328 | .111 | |
| BDD-FVIII-H1H2 | 1.054 | .67 | 1.054 | .671 | |
| BDD-FVIII-H3 | 1.265 | .09 | 1.269 | .088 | |
| BDD-FVIII-H4 | 1.167 | .233 | 1.17 | .227 | |
| Protein average | 1.26 | .065 | 1.261 | .066 | |
| Black individuals with severe HA (n = 149) vs White individuals with severe HA (n = 174) | FL-FVIII-H1 | 0.907 | .387 | 0.894 | .323 |
| FL-FVIII-H2 | 0.958 | .689 | 0.942 | .577 | |
| BDD-FVIII-H1H2 | 1.024 | .773 | 1.007 | .93 | |
| BDD-FVIII-H3 | 1.014 | .846 | 1.001 | .987 | |
| BDD-FVIII-H4 | 0.996 | .958 | 0.98 | .798 | |
| Protein average | 0.977 | .759 | 0.961 | .604 | |
| Black individuals with mild + moderate HA (n = 23) vs White individuals with mild + moderate HA (n = 20) | FL-FVIII-H1 | 1.531 | .163 | 3.347 | .007 |
| FL-FVIII-H2 | 1.342 | .35 | 2.56 | .046 | |
| BDD-FVIII-H1H2 | 0.866 | .536 | 1.435 | .286 | |
| BDD-FVIII-H3 | 0.871 | .564 | 1.485 | .256 | |
| BDD-FVIII-H4 | 0.739 | .158 | 1.226 | .502 | |
| Protein average | 1.028 | .902 | 1.862 | .053 | |
| Comparison∗ . | Variable . | Not adjusted for inhibitor history . | Adjusted for inhibitor history . | ||
|---|---|---|---|---|---|
| Ratio . | P value . | Ratio . | P value . | ||
| Individuals (n = 323) with severe HA vs family controls (n = 23) | FL-FVIII-H1 | 1.93 | .008 | 1.824 | .016 |
| FL-FVIII-H2 | 1.73 | .018 | 1.62 | .039 | |
| BDD-FVIII-H1H2 | 1.422 | .052 | 1.332 | .117 | |
| BDD-FVIII-H3 | 1.462 | .019 | 1.388 | .045 | |
| BDD-FVIII-H4 | 1.489 | .019 | 1.401 | .049 | |
| FVIII protein average | 1.594 | .005 | 1.499 | .017 | |
| Individuals with severe HA (n = 323) vs those with mild + moderate HA (n = 43) | FL-FVIII-H1 | 1.323 | .089 | 1.324 | .086 |
| FL-FVIII-H2 | 1.221 | .2 | 1.222 | .196 | |
| BDD-FVIII-H1H2 | 0.977 | .848 | 0.978 | .851 | |
| BDD-FVIII-H3 | 0.955 | .669 | 0.956 | .671 | |
| BDD-FVIII-H4 | 0.935 | .544 | 0.935 | .544 | |
| FVIII protein average | 1.07 | .546 | 1.07 | .543 | |
| Individuals with mild + moderate HA (n = 43) vs family controls (n = 23) | FL-FVIII-H1 | 0.793 | .59 | 0.797 | .577 |
| FL-FVIII-H2 | 1.038 | .929 | 1.042 | .918 | |
| BDD-FVIII-H1H2 | 1.105 | .741 | 1.107 | .735 | |
| BDD-FVIII-H3 | 1.054 | .859 | 1.056 | .851 | |
| BDD-FVIII-H4 | 1.329 | .332 | 1.331 | .327 | |
| FVIII protein average | 1.05 | .871 | 1.052 | .859 | |
| Individuals with severe HA with intron-22 inversion (n = 124) vs those with severe HA without intron-22 inversion (n = 165) | FL-FVIII-H1 | 0.894 | .362 | 0.878 | .29 |
| FL-FVIII-H2 | 0.906 | .398 | 0.893 | .333 | |
| BDD-FVIII-H1H2 | 1.06 | .524 | 1.045 | .631 | |
| BDD-FVIII-H3 | 0.992 | .921 | 0.98 | .798 | |
| BDD-FVIII-H4 | 1.007 | .936 | 0.991 | .919 | |
| FVIII protein average | 0.962 | .648 | 0.947 | .526 | |
| Individuals with severe HA treated with BDD-FVIII (n = 34) vs those with severe HA not treated with BDD-FVIII (n = 229) | FL-FVIII-H1 | 1.531 | .022 | 1.53 | .023 |
| FL-FVIII-H2 | 1.333 | .105 | 1.328 | .111 | |
| BDD-FVIII-H1H2 | 1.054 | .67 | 1.054 | .671 | |
| BDD-FVIII-H3 | 1.265 | .09 | 1.269 | .088 | |
| BDD-FVIII-H4 | 1.167 | .233 | 1.17 | .227 | |
| Protein average | 1.26 | .065 | 1.261 | .066 | |
| Black individuals with severe HA (n = 149) vs White individuals with severe HA (n = 174) | FL-FVIII-H1 | 0.907 | .387 | 0.894 | .323 |
| FL-FVIII-H2 | 0.958 | .689 | 0.942 | .577 | |
| BDD-FVIII-H1H2 | 1.024 | .773 | 1.007 | .93 | |
| BDD-FVIII-H3 | 1.014 | .846 | 1.001 | .987 | |
| BDD-FVIII-H4 | 0.996 | .958 | 0.98 | .798 | |
| Protein average | 0.977 | .759 | 0.961 | .604 | |
| Black individuals with mild + moderate HA (n = 23) vs White individuals with mild + moderate HA (n = 20) | FL-FVIII-H1 | 1.531 | .163 | 3.347 | .007 |
| FL-FVIII-H2 | 1.342 | .35 | 2.56 | .046 | |
| BDD-FVIII-H1H2 | 0.866 | .536 | 1.435 | .286 | |
| BDD-FVIII-H3 | 0.871 | .564 | 1.485 | .256 | |
| BDD-FVIII-H4 | 0.739 | .158 | 1.226 | .502 | |
| Protein average | 1.028 | .902 | 1.862 | .053 | |
P values <0.05 are set in bold.
Adjusted for age, and whether the individuals with HA were related to any other individuals with HA. Models in which the primary comparison did not involve race were adjusted for race.