Table 5. Ratios of antibody binding to... | American Society of Hematology

Table 5.

Ratios of antibody binding to same-sized FVIII proteins (paired t tests)

	N	BDD_H1H2/BDD_H3H5	BDD_H1H2/BDD_H4	BDD_H3H5/BDD_H4	FL_H2/FL_H1
All SHA	347	0.9∗∗	NS	1.1∗	NS
SHA Black	162	0.9∗	NS	1.1∗	NS
SHA White	185	0.9∗	NS	NS	NS
All HA current inhibitor	28	0.0∗	NS	1.2∗∗	NS
All HA no current inhibitor	366	0.9∗∗	NS	NS	NS
SHA current inhibitor	24	0.8∗∗	NS	1.3∗∗	NS
SHA no current inhibitor	323	0.9∗	NS	NS	NS
All MHA	47	0.9∗∗	NS	NS	NS
MHA Black	26	0.9∗	NS	1.2∗∗	NS
MHA White	21	NS	NS	NS	NS
SHA treated with BDD-FVIII	35	1.3∗∗	NS	NS	NS
SHA not treated with BDD-FVIII	247	0.9∗∗	NS	1.1∗	NS
SHA intron-22 inversion	138	NS	NS	NS	NS
SHA not intron-22 inversion	172	0.9∗∗	NS	1.1∗	NS
SHA H1 haplotype mismatched	150	NS	NS	NS	NS
SHA H2 haplotype mismatched	86	0.9∗	NS	1.1∗	NS
SHA H3 + H5	29	NS	NS	1.2∗∗	NS
SHA not haplotype mismatched	74	NS	NS	NS	NS
MHA H1 haplotype mismatched	16	0.8∗	NS	NS	NS
MHA H2 haplotype mismatched	14	0.8∗	NS	1.2∗	NS
MHA H3 + H5	3	NS	NS	NS	NS
MHA not haplotype mismatched	9	NS	NS	NS	NS
Family controls	23	NS	NS	1.1∗∗	NS

	N	BDD_H1H2/BDD_H3H5	BDD_H1H2/BDD_H4	BDD_H3H5/BDD_H4	FL_H2/FL_H1
All SHA	347	0.9∗∗	NS	1.1∗	NS
SHA Black	162	0.9∗	NS	1.1∗	NS
SHA White	185	0.9∗	NS	NS	NS
All HA current inhibitor	28	0.0∗	NS	1.2∗∗	NS
All HA no current inhibitor	366	0.9∗∗	NS	NS	NS
SHA current inhibitor	24	0.8∗∗	NS	1.3∗∗	NS
SHA no current inhibitor	323	0.9∗	NS	NS	NS
All MHA	47	0.9∗∗	NS	NS	NS
MHA Black	26	0.9∗	NS	1.2∗∗	NS
MHA White	21	NS	NS	NS	NS
SHA treated with BDD-FVIII	35	1.3∗∗	NS	NS	NS
SHA not treated with BDD-FVIII	247	0.9∗∗	NS	1.1∗	NS
SHA intron-22 inversion	138	NS	NS	NS	NS
SHA not intron-22 inversion	172	0.9∗∗	NS	1.1∗	NS
SHA H1 haplotype mismatched	150	NS	NS	NS	NS
SHA H2 haplotype mismatched	86	0.9∗	NS	1.1∗	NS
SHA H3 + H5	29	NS	NS	1.2∗∗	NS
SHA not haplotype mismatched	74	NS	NS	NS	NS
MHA H1 haplotype mismatched	16	0.8∗	NS	NS	NS
MHA H2 haplotype mismatched	14	0.8∗	NS	1.2∗	NS
MHA H3 + H5	3	NS	NS	NS	NS
MHA not haplotype mismatched	9	NS	NS	NS	NS
Family controls	23	NS	NS	1.1∗∗	NS

SHA, severe HA; MHA, mild + moderate HA; INT22INV, intron-22 inversion.

∗P < .05; ∗∗P < .01.