Ratios of antibody binding to BDD-FVIII proteins vs FL FVIII proteins (paired t tests)
| . | N . | BDD_H1H2/FL_H1 . | BDD_H3H5/FL_H1 . | BDD_H4/FL_H1 . | BDD_H1H2/FL_H2 . | BDD_H3H5/FL_H2 . | BDD_H4/FL_H2 . |
|---|---|---|---|---|---|---|---|
| All SHA | 347 | 3.2∗∗∗∗ | 3.5∗∗∗∗ | 3.4∗∗∗∗ | 3.2∗∗∗∗ | 3.6∗∗∗∗ | 3.4∗∗∗∗ |
| SHA Black | 162 | 3.8∗∗∗∗ | 4.1∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ |
| SHA White | 185 | 2.8∗∗∗∗ | 3.1∗∗∗∗ | 3.0∗∗∗∗ | 2.9∗∗∗∗ | 3.3∗∗∗∗ | 3.2∗∗∗∗ |
| All HA current inhibitor | 28 | NS | 2.2∗ | NS | 1.9∗ | 2.3∗ | NS |
| All HA no current inhibitor | 366 | 3.6∗∗∗∗ | 3.9∗∗∗∗ | 3.8∗∗∗∗ | 3.5∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ |
| SHA current inhibitor | 24 | 2.3∗ | 2.8∗∗ | 2.2∗ | 2.5∗ | 3.1∗ | 2.4∗ |
| SHA no current inhibitor | 323 | 3.3∗∗∗∗ | 3.6∗∗∗∗ | 3.5∗∗∗∗ | 3.3∗∗∗∗ | 3.6∗∗∗∗ | 3.5∗∗∗∗ |
| All MHA | 47 | 5.1∗∗∗ | 5.9∗∗∗∗ | 5.8∗∗∗∗ | 4.2∗∗∗ | 4.9∗∗∗∗ | 4.9∗∗∗ |
| MHA Black | 26 | 3.3∗∗ | 3.9∗∗ | 3.3∗∗ | 2.9∗ | 3.3∗∗ | 2.8∗ |
| MHA White | 21 | 8.7∗∗ | 10.0∗∗ | 12.0∗∗ | 6.9∗∗ | 7.9∗∗ | 9.5∗∗∗ |
| SHA treated with BDD-FVIII | 35 | NS | NS | NS | 2.8∗ | 2.2∗ | 2.5∗ |
| SHA not treated with BDD-FVIII | 247 | 3.6∗∗∗∗ | 4.1∗∗∗∗ | 3.8∗∗∗∗ | 3.3∗∗∗∗ | 3.8∗∗∗∗ | 3.5∗∗∗∗ |
| SHA intron-22 inversion | 138 | 3.6∗∗∗∗ | 3.7∗∗∗∗ | 3.6∗∗∗∗ | 3.6∗∗∗∗ | 3.7∗∗∗∗ | 3.6∗∗∗∗ |
| SHA not intron-22 inversion | 172 | 2.5∗∗∗∗ | 2.9∗∗∗∗ | 2.7∗∗∗∗ | 2.7∗∗∗∗ | 3.1∗∗∗∗ | 2.9∗∗∗∗ |
| SHA H1 haplotype mismatched | 150 | 3.6∗∗∗∗ | 4.1∗∗∗∗ | 4.0∗∗∗∗ | 3.4∗∗∗∗ | 3.8∗∗∗∗ | 3.7∗∗∗∗ |
| SHA H2 haplotype mismatched | 86 | 3.4∗∗∗∗ | 3.8∗∗∗∗ | 3.4∗∗∗∗ | 3.1∗∗∗∗ | 3.6∗∗∗∗ | 3.3∗∗∗∗ |
| SHA H3 + H5 | 29 | 3.1∗ | 3.8∗∗ | 3.1∗ | 3.1∗∗ | 3.7∗∗ | 3.0∗ |
| SHA not haplotype mismatched | 74 | 2.6∗∗∗ | 2.6∗∗∗ | 2.6∗∗∗ | 3.1∗∗ | 3.1∗∗ | 3.1∗∗ |
| MHA H1 haplotype mismatched | 16 | 8.5∗ | 10.7∗∗ | 12.9∗∗ | 6.1∗ | 7.7∗∗ | 9.3∗∗ |
| MHA H2 haplotype mismatched | 14 | NS | 3.1∗ | NS | NS | NS | NS |
| MHA H3 + H5 | 3 | NS | NS | NS | NS | NS | NS |
| MHA not haplotype mismatched | 9 | NS | 8.8∗ | 8.5∗ | 11.2∗ | 10.3∗ | 10.1∗ |
| Family controls | 23 | 6.6∗∗ | 5.7∗ | 5.6∗ | 6.7∗∗ | 6.6∗∗ | 5.8∗∗ |
| . | N . | BDD_H1H2/FL_H1 . | BDD_H3H5/FL_H1 . | BDD_H4/FL_H1 . | BDD_H1H2/FL_H2 . | BDD_H3H5/FL_H2 . | BDD_H4/FL_H2 . |
|---|---|---|---|---|---|---|---|
| All SHA | 347 | 3.2∗∗∗∗ | 3.5∗∗∗∗ | 3.4∗∗∗∗ | 3.2∗∗∗∗ | 3.6∗∗∗∗ | 3.4∗∗∗∗ |
| SHA Black | 162 | 3.8∗∗∗∗ | 4.1∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ |
| SHA White | 185 | 2.8∗∗∗∗ | 3.1∗∗∗∗ | 3.0∗∗∗∗ | 2.9∗∗∗∗ | 3.3∗∗∗∗ | 3.2∗∗∗∗ |
| All HA current inhibitor | 28 | NS | 2.2∗ | NS | 1.9∗ | 2.3∗ | NS |
| All HA no current inhibitor | 366 | 3.6∗∗∗∗ | 3.9∗∗∗∗ | 3.8∗∗∗∗ | 3.5∗∗∗∗ | 3.9∗∗∗∗ | 3.7∗∗∗∗ |
| SHA current inhibitor | 24 | 2.3∗ | 2.8∗∗ | 2.2∗ | 2.5∗ | 3.1∗ | 2.4∗ |
| SHA no current inhibitor | 323 | 3.3∗∗∗∗ | 3.6∗∗∗∗ | 3.5∗∗∗∗ | 3.3∗∗∗∗ | 3.6∗∗∗∗ | 3.5∗∗∗∗ |
| All MHA | 47 | 5.1∗∗∗ | 5.9∗∗∗∗ | 5.8∗∗∗∗ | 4.2∗∗∗ | 4.9∗∗∗∗ | 4.9∗∗∗ |
| MHA Black | 26 | 3.3∗∗ | 3.9∗∗ | 3.3∗∗ | 2.9∗ | 3.3∗∗ | 2.8∗ |
| MHA White | 21 | 8.7∗∗ | 10.0∗∗ | 12.0∗∗ | 6.9∗∗ | 7.9∗∗ | 9.5∗∗∗ |
| SHA treated with BDD-FVIII | 35 | NS | NS | NS | 2.8∗ | 2.2∗ | 2.5∗ |
| SHA not treated with BDD-FVIII | 247 | 3.6∗∗∗∗ | 4.1∗∗∗∗ | 3.8∗∗∗∗ | 3.3∗∗∗∗ | 3.8∗∗∗∗ | 3.5∗∗∗∗ |
| SHA intron-22 inversion | 138 | 3.6∗∗∗∗ | 3.7∗∗∗∗ | 3.6∗∗∗∗ | 3.6∗∗∗∗ | 3.7∗∗∗∗ | 3.6∗∗∗∗ |
| SHA not intron-22 inversion | 172 | 2.5∗∗∗∗ | 2.9∗∗∗∗ | 2.7∗∗∗∗ | 2.7∗∗∗∗ | 3.1∗∗∗∗ | 2.9∗∗∗∗ |
| SHA H1 haplotype mismatched | 150 | 3.6∗∗∗∗ | 4.1∗∗∗∗ | 4.0∗∗∗∗ | 3.4∗∗∗∗ | 3.8∗∗∗∗ | 3.7∗∗∗∗ |
| SHA H2 haplotype mismatched | 86 | 3.4∗∗∗∗ | 3.8∗∗∗∗ | 3.4∗∗∗∗ | 3.1∗∗∗∗ | 3.6∗∗∗∗ | 3.3∗∗∗∗ |
| SHA H3 + H5 | 29 | 3.1∗ | 3.8∗∗ | 3.1∗ | 3.1∗∗ | 3.7∗∗ | 3.0∗ |
| SHA not haplotype mismatched | 74 | 2.6∗∗∗ | 2.6∗∗∗ | 2.6∗∗∗ | 3.1∗∗ | 3.1∗∗ | 3.1∗∗ |
| MHA H1 haplotype mismatched | 16 | 8.5∗ | 10.7∗∗ | 12.9∗∗ | 6.1∗ | 7.7∗∗ | 9.3∗∗ |
| MHA H2 haplotype mismatched | 14 | NS | 3.1∗ | NS | NS | NS | NS |
| MHA H3 + H5 | 3 | NS | NS | NS | NS | NS | NS |
| MHA not haplotype mismatched | 9 | NS | 8.8∗ | 8.5∗ | 11.2∗ | 10.3∗ | 10.1∗ |
| Family controls | 23 | 6.6∗∗ | 5.7∗ | 5.6∗ | 6.7∗∗ | 6.6∗∗ | 5.8∗∗ |
SHA, severe HA; MHA, mild + moderate HA; INT22INV, intron-22 inversion.
∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.