Amino acid variants and haplotypes of the 5 recombinant FVIII proteins
| Polymorphic amino acid . | rFVIII-H1 (Kogenate) . | rFVIII-H2 (recombinate) . | BDD-FVIII-H1/H2 . | BDD-FVIII-H3/H5 . | BDD-FVIII-H4 . |
|---|---|---|---|---|---|
| R484H | R | R | R | R | H |
| D1241E | D | E | n/a∗ | n/a∗ | n/a∗ |
| M2238V | M | M | M | V | M |
| Polymorphic amino acid . | rFVIII-H1 (Kogenate) . | rFVIII-H2 (recombinate) . | BDD-FVIII-H1/H2 . | BDD-FVIII-H3/H5 . | BDD-FVIII-H4 . |
|---|---|---|---|---|---|
| R484H | R | R | R | R | H |
| D1241E | D | E | n/a∗ | n/a∗ | n/a∗ |
| M2238V | M | M | M | V | M |
Note that residue 1241 is in the FVIII B domain and therefore not present in BDD-FVIII protein.