Table 2. Multivariable analysis of... | American Society of Hematology

Table 2.

Multivariable analysis of factors that may be associated with each relapse immunophenotype

Parameter	Parameter estimate	Standard error	χ²	P	Hazard ratio	95% CI
CD19^posrelapse
≥ 2 CRs	0.26	0.1	7.06	.008	1.3	1.07-1.58
CD19^negrelapse
Younger age (<7 y) at CAR	1.23	0.27	20.78	<.001	3.42	2.02-5.81
KMT2Ar presence	−2.51	1.02	6.03	.01	0.08	0.01-0.6
CAR type∗	1.51	0.72	4.37	.04	0.22	0.05-0.91
High disease burden	1.64	0.29	32.28	<.001	5.17	2.93-9.11
Blina nonresponse	1.05	0.37	8	.005	2.85	1.38-5.89
Lineage switch
KMT2Ar presence	3.48	0.67	27.11	<.0001	32.35	8.74-119.71

Parameter	Parameter estimate	Standard error	χ²	P	Hazard ratio	95% CI
CD19^posrelapse
≥ 2 CRs	0.26	0.1	7.06	.008	1.3	1.07-1.58
CD19^negrelapse
Younger age (<7 y) at CAR	1.23	0.27	20.78	<.001	3.42	2.02-5.81
KMT2Ar presence	−2.51	1.02	6.03	.01	0.08	0.01-0.6
CAR type∗	1.51	0.72	4.37	.04	0.22	0.05-0.91
High disease burden	1.64	0.29	32.28	<.001	5.17	2.93-9.11
Blina nonresponse	1.05	0.37	8	.005	2.85	1.38-5.89
Lineage switch
KMT2Ar presence	3.48	0.67	27.11	<.0001	32.35	8.74-119.71

CD28z CAR associated with lower risk of CD19^neg relapse.