Input parameters for utility values
| Health state . | Utility value . | Source . | |
|---|---|---|---|
| Preprogression, IV treatment | 0.67 | ||
| Preprogression, oral treatment | 0.71 | 48 | |
| Preprogression, off-treatment | 0.77 | Kosmas et al49 | |
| Progressed | 0.6 | ||
| Health state . | Utility value . | Source . | |
|---|---|---|---|
| Preprogression, IV treatment | 0.67 | ||
| Preprogression, oral treatment | 0.71 | 48 | |
| Preprogression, off-treatment | 0.77 | Kosmas et al49 | |
| Progressed | 0.6 | ||
| Adverse event . | Disutility value . | Duration, days . | Source . |
|---|---|---|---|
| Acute coronary syndrome | 0.18 | On treatment | Gencer et al50 |
| Anemia | 0.09 | 30 | Beusterien et al51 |
| Arthralgia | 0.05 | On treatment | Assumed same as nausea |
| Atrial fibrillation | 0.0557 | On treatment | Sullivan et al52 |
| Diarrhea | 0.176 | 5 | Stein et al53 |
| Dizziness/fatigue | 0.05 | 30 | Assumed same as nausea |
| Febrile neutropenia | 0.195 | 7 | Tolley et al54 |
| Headache | 0.05 | 7 | Assumed same as nausea |
| Hemorrhage | 0.131 | 14 | Wehler et al55 |
| Hyperglycemia | 0.06 | On treatment | Nafees et al56 |
| Hypertension | 0.0375 | On treatment | Sullivan et al52 |
| Hypogammaglobulinemia | 0.09 | On treatment | Assumed same as anemia |
| Infections and infestations | 0.195 | 7 | Tolley et al54 |
| Infusion-related reaction | 0.2 | 1 | Chatterjee et al31 |
| Leukopenia | 0.163 | 30 | Assumed same as neutropenia |
| Myalgia | 0.05 | On treatment | Assumed same as nausea |
| Neutropenia and neutrophil count decreased | 0.163 | 30 | Tolley et al54 |
| Pneumonia | 0.195 | 7 | Tolley et al54 |
| Pyrexia | 0.11 | 7 | Beusterien et al51 |
| Rash, maculopapular | 0.06 | 14 | Stein et al53 |
| Sepsis | 0.195 | 10 | Tolley et al54 |
| Thrombocytopenia and low platelet count | 0.108 | 30 | Tolley et al54 |
| Tumor lysis syndrome | 0.195 | 5 | Tolley et al54 |
| Urinary tract infection | 0.195 | 5 | Tolley et al54 |
| Adverse event . | Disutility value . | Duration, days . | Source . |
|---|---|---|---|
| Acute coronary syndrome | 0.18 | On treatment | Gencer et al50 |
| Anemia | 0.09 | 30 | Beusterien et al51 |
| Arthralgia | 0.05 | On treatment | Assumed same as nausea |
| Atrial fibrillation | 0.0557 | On treatment | Sullivan et al52 |
| Diarrhea | 0.176 | 5 | Stein et al53 |
| Dizziness/fatigue | 0.05 | 30 | Assumed same as nausea |
| Febrile neutropenia | 0.195 | 7 | Tolley et al54 |
| Headache | 0.05 | 7 | Assumed same as nausea |
| Hemorrhage | 0.131 | 14 | Wehler et al55 |
| Hyperglycemia | 0.06 | On treatment | Nafees et al56 |
| Hypertension | 0.0375 | On treatment | Sullivan et al52 |
| Hypogammaglobulinemia | 0.09 | On treatment | Assumed same as anemia |
| Infections and infestations | 0.195 | 7 | Tolley et al54 |
| Infusion-related reaction | 0.2 | 1 | Chatterjee et al31 |
| Leukopenia | 0.163 | 30 | Assumed same as neutropenia |
| Myalgia | 0.05 | On treatment | Assumed same as nausea |
| Neutropenia and neutrophil count decreased | 0.163 | 30 | Tolley et al54 |
| Pneumonia | 0.195 | 7 | Tolley et al54 |
| Pyrexia | 0.11 | 7 | Beusterien et al51 |
| Rash, maculopapular | 0.06 | 14 | Stein et al53 |
| Sepsis | 0.195 | 10 | Tolley et al54 |
| Thrombocytopenia and low platelet count | 0.108 | 30 | Tolley et al54 |
| Tumor lysis syndrome | 0.195 | 5 | Tolley et al54 |
| Urinary tract infection | 0.195 | 5 | Tolley et al54 |