Genome-wide significant variants associated with blood cell traits
| Blood cell trait . | Variant . | Chromosome . | Position∗ . | Gene . | Reference/alternative allele . | Alternative allele frequency . | Beta (in SD units of the trait) . | P . | Annotation . |
|---|---|---|---|---|---|---|---|---|---|
| White blood count (n = 2842) | rs150060808 | 17 | 38 126 911 | GSDMA | AACACACAC/A | 0.4070 | 0.1657 (0.0285) | 5.80 × 10–9 | Intronic |
| rs4239225 | 17 | 38 127 112 | GSDMA | G/A | 0.4555 | 0.1626 (0.0280) | 6.0 × 10–9 | Intronic | |
| rs3859192 | 17 | 38 128 648 | GSDMA | C/T | 0.4555 | 0.1616 (0.0279) | 6.6 × 10–9 | Intronic | |
| rs3859191 | 17 | 38 128 714 | GSDMA | G/A | 0.4554 | 0.1617 (0.0279) | 6.5 × 10–9 | Intronic | |
| rs4065876 | 17 | 38 129 506 | GSDMA | G/A | 0.4557 | 0.1618 (0.0279) | 6.5 × 10–9 | Intronic | |
| rs60137005 | 17 | 38 129 996 | GSDMA | A/T | 0.4558 | 0.1619 (0.0279) | 6.4 × 10–9 | Intronic | |
| rs56326707 | 17 | 38 130 139 | GSDMA | C/T | 0.4559 | 0.1619 (0.0279) | 6.4 × 10–9 | Intronic | |
| rs56030650 | 17 | 38 131 187 | GSDMA | C/A | 0.4562 | 0.1621 (0.0279) | 6.2 × 10-9 | Exonic | |
| rs60134943 | 17 | 38 133 792 | GSDMA | G/T | 0.4569 | 0.1623 (0.0279) | 6.1 × 10–9 | 3′UTR | |
| rs3907022 | 17 | 38 134 889 | GSDMA | T/C | 0.4571 | 0.1622 (0.0279) | 6.3 × 10–9 | Downstream | |
| Neutrophils (n = 2847) | rs150060808 | 17 | 38 126 911 | GSDMA | AACACACAC/A | 0.4073 | 0.1679 (0.0284) | 3.5 × 10–9 | Intronic |
| rs4239225 | 17 | 38 127 112 | GSDMA | G/A | 0.4557 | 0.1729 (0.0280) | 6.2 × 10–10 | Intronic | |
| rs3859192 | 17 | 38 128 648 | GSDMA | C/T | 0.4557 | 0.1718 (0.0278) | 6.8 × 10–10 | Intronic | |
| rs3859191 | 17 | 38 128 714 | GSDMA | G/A | 0.4557 | 0.1720 (0.0278) | 6.6 × 10–10 | Intronic | |
| rs4065876 | 17 | 38 129 506 | GSDMA | G/A | 0.4559 | 0.1721 (0.0279) | 6.6 × 10–10 | Intronic | |
| rs60137005 | 17 | 38 129 996 | GSDMA | A/T | 0.4561 | 0.1722 (0.0279) | 6.5 × 10–10 | Intronic | |
| rs56326707 | 17 | 38 130 139 | GSDMA | C/T | 0.4561 | 0.1723 (0.0279) | 6.4 × 10–10 | Intronic | |
| rs56030650 | 17 | 38 131 187 | GSDMA | C/A | 0.4564 | 0.1725 (0.0279) | 6.2 × 10–10 | Exonic | |
| rs60134943 | 17 | 38 133 792 | GSDMA | G/T | 0.4571 | 0.1729 (0.0279) | 5.9 × 10–10 | 3′UTR | |
| rs3907022 | 17 | 38 134 889 | GSDMA | T/C | 0.4573 | 0.1728 (0.0279) | 6.0 × 10–10 | Downstream | |
| rs8068260 | 17 | 38 163 650 | PSMD3-CSF3 | T/C | 0.5199 | 0.1608 (0.0280) | 9.8 × 10–9 | Intergenic | |
| rs8067817 | 17 | 38 163 936 | PSMD3-CSF3 | C/T | 0.5208 | 0.1613 (0.0281) | 9.1 × 10–9 | Intergenic | |
| rs8072548 | 17 | 38 164 025 | PSMD3-CSF3 | T/G | 0.5208 | 0.1613 (0.0281) | 9.1 × 10–9 | Intergenic | |
| rs139156536 | 17 | 38 164 432 | PSMD3-CSF3 | TTTTA/T | 0.5198 | 0.1610 (0.0280) | 9.4 × 10–9 | Intergenic | |
| rs7222039 | 17 | 38 165 541 | PSMD3-CSF3 | T/C | 0.5207 | 0.1612 (0.0281) | 9.2 × 10–9 | Intergenic | |
| Platelets (n = 2841) | rs1354034 | 3 | 56 849 749 | ARHGEF3 | T/C | 0.5906 | 0.1727 (0.0291) | 3.0 × 10–9 | Intronic |
| Blood cell trait . | Variant . | Chromosome . | Position∗ . | Gene . | Reference/alternative allele . | Alternative allele frequency . | Beta (in SD units of the trait) . | P . | Annotation . |
|---|---|---|---|---|---|---|---|---|---|
| White blood count (n = 2842) | rs150060808 | 17 | 38 126 911 | GSDMA | AACACACAC/A | 0.4070 | 0.1657 (0.0285) | 5.80 × 10–9 | Intronic |
| rs4239225 | 17 | 38 127 112 | GSDMA | G/A | 0.4555 | 0.1626 (0.0280) | 6.0 × 10–9 | Intronic | |
| rs3859192 | 17 | 38 128 648 | GSDMA | C/T | 0.4555 | 0.1616 (0.0279) | 6.6 × 10–9 | Intronic | |
| rs3859191 | 17 | 38 128 714 | GSDMA | G/A | 0.4554 | 0.1617 (0.0279) | 6.5 × 10–9 | Intronic | |
| rs4065876 | 17 | 38 129 506 | GSDMA | G/A | 0.4557 | 0.1618 (0.0279) | 6.5 × 10–9 | Intronic | |
| rs60137005 | 17 | 38 129 996 | GSDMA | A/T | 0.4558 | 0.1619 (0.0279) | 6.4 × 10–9 | Intronic | |
| rs56326707 | 17 | 38 130 139 | GSDMA | C/T | 0.4559 | 0.1619 (0.0279) | 6.4 × 10–9 | Intronic | |
| rs56030650 | 17 | 38 131 187 | GSDMA | C/A | 0.4562 | 0.1621 (0.0279) | 6.2 × 10-9 | Exonic | |
| rs60134943 | 17 | 38 133 792 | GSDMA | G/T | 0.4569 | 0.1623 (0.0279) | 6.1 × 10–9 | 3′UTR | |
| rs3907022 | 17 | 38 134 889 | GSDMA | T/C | 0.4571 | 0.1622 (0.0279) | 6.3 × 10–9 | Downstream | |
| Neutrophils (n = 2847) | rs150060808 | 17 | 38 126 911 | GSDMA | AACACACAC/A | 0.4073 | 0.1679 (0.0284) | 3.5 × 10–9 | Intronic |
| rs4239225 | 17 | 38 127 112 | GSDMA | G/A | 0.4557 | 0.1729 (0.0280) | 6.2 × 10–10 | Intronic | |
| rs3859192 | 17 | 38 128 648 | GSDMA | C/T | 0.4557 | 0.1718 (0.0278) | 6.8 × 10–10 | Intronic | |
| rs3859191 | 17 | 38 128 714 | GSDMA | G/A | 0.4557 | 0.1720 (0.0278) | 6.6 × 10–10 | Intronic | |
| rs4065876 | 17 | 38 129 506 | GSDMA | G/A | 0.4559 | 0.1721 (0.0279) | 6.6 × 10–10 | Intronic | |
| rs60137005 | 17 | 38 129 996 | GSDMA | A/T | 0.4561 | 0.1722 (0.0279) | 6.5 × 10–10 | Intronic | |
| rs56326707 | 17 | 38 130 139 | GSDMA | C/T | 0.4561 | 0.1723 (0.0279) | 6.4 × 10–10 | Intronic | |
| rs56030650 | 17 | 38 131 187 | GSDMA | C/A | 0.4564 | 0.1725 (0.0279) | 6.2 × 10–10 | Exonic | |
| rs60134943 | 17 | 38 133 792 | GSDMA | G/T | 0.4571 | 0.1729 (0.0279) | 5.9 × 10–10 | 3′UTR | |
| rs3907022 | 17 | 38 134 889 | GSDMA | T/C | 0.4573 | 0.1728 (0.0279) | 6.0 × 10–10 | Downstream | |
| rs8068260 | 17 | 38 163 650 | PSMD3-CSF3 | T/C | 0.5199 | 0.1608 (0.0280) | 9.8 × 10–9 | Intergenic | |
| rs8067817 | 17 | 38 163 936 | PSMD3-CSF3 | C/T | 0.5208 | 0.1613 (0.0281) | 9.1 × 10–9 | Intergenic | |
| rs8072548 | 17 | 38 164 025 | PSMD3-CSF3 | T/G | 0.5208 | 0.1613 (0.0281) | 9.1 × 10–9 | Intergenic | |
| rs139156536 | 17 | 38 164 432 | PSMD3-CSF3 | TTTTA/T | 0.5198 | 0.1610 (0.0280) | 9.4 × 10–9 | Intergenic | |
| rs7222039 | 17 | 38 165 541 | PSMD3-CSF3 | T/C | 0.5207 | 0.1612 (0.0281) | 9.2 × 10–9 | Intergenic | |
| Platelets (n = 2841) | rs1354034 | 3 | 56 849 749 | ARHGEF3 | T/C | 0.5906 | 0.1727 (0.0291) | 3.0 × 10–9 | Intronic |
UTR, untranslated region.
Genome assembly GRCh37 – hg19