Graph properties for the full network under each weighting scheme, as well as the subnetworks composed of those cortical nodes whose strengths are significantly different between patients and control subjects
| . | Whole-brain network (streamline-weighted) . | Whole-brain network (FA-weighted) . | Selected subnetwork (streamline-weighted) . | Selected subnetwork (FA-weighted) . |
|---|---|---|---|---|
| Cortical ROIs (nodes), N | 68 | 68 | 10 | 16 |
| Mean (SD) edge density, % | ||||
| Control Subjects | 75.0 (4.5) | 75.0 (4.5) | 98.3 (1.7) | 79.9 (8.6) |
| Patients | 71.5 (5.1) | 71.5 (5.1) | 96.3 (3.1) | 70.9 (8.0) |
| Effect size (Cohen’s d) | −0.72 | −0.72 | −0.76 | −1.09 |
| Mean (SD) global efficiency | ||||
| Control Subjects | 0.314 (0.034) | 0.423 (0.016) | 0.384 (0.085) | 0.421 (0.024) |
| Patients | 0.314 (0.053) | 0.414 (0.017) | 0.315 (0.066) | 0.399 (0.023) |
| Effect size (Cohen’s d) | 0.01 | −0.53 | −0.94 | −0.97 |
| . | Whole-brain network (streamline-weighted) . | Whole-brain network (FA-weighted) . | Selected subnetwork (streamline-weighted) . | Selected subnetwork (FA-weighted) . |
|---|---|---|---|---|
| Cortical ROIs (nodes), N | 68 | 68 | 10 | 16 |
| Mean (SD) edge density, % | ||||
| Control Subjects | 75.0 (4.5) | 75.0 (4.5) | 98.3 (1.7) | 79.9 (8.6) |
| Patients | 71.5 (5.1) | 71.5 (5.1) | 96.3 (3.1) | 70.9 (8.0) |
| Effect size (Cohen’s d) | −0.72 | −0.72 | −0.76 | −1.09 |
| Mean (SD) global efficiency | ||||
| Control Subjects | 0.314 (0.034) | 0.423 (0.016) | 0.384 (0.085) | 0.421 (0.024) |
| Patients | 0.314 (0.053) | 0.414 (0.017) | 0.315 (0.066) | 0.399 (0.023) |
| Effect size (Cohen’s d) | 0.01 | −0.53 | −0.94 | −0.97 |
FA, fractional anisotropy; ROI, region of interest; SD, standard deviation.
An absolute Cohen’s d value of 0.5 is conventionally considered to be a medium effect, and 0.8 a large effect.