Numbers, events, person-years, 10-year risks, and overall (0-10 years) adjusted HRs of CVT recurrence, VTE in other sites, myocardial infarction, ischemic stroke, and all-cause mortality comparing patients with a first-time diagnosis of CVT and matched comparators from the GP; and additional analyses of patients with CVT initiation and discontinuing anticoagulants
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR (95% CI)∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference (95% CI) . | ||
| CVT recurrence | ||||||||||
| All | 309 | 30 900 | 5 | — | 1 831 | — | 2.4 | — | — | — |
| Women, aged 18-54 y | 174 | 17 483 | <5 | — | 1 102 | — | 3.2 | — | — | — |
| Women, aged ≥55 y | 43 | 4 217 | 0 | — | 214 | — | — | — | — | — |
| Men, aged 18-54 y | 56 | 5 630 | <5 | — | 352 | — | 2.6 | — | — | — |
| Men, aged ≥55 y | 36 | 3 570 | 0 | — | 164 | — | — | — | — | — |
| VTE | ||||||||||
| All | 309 | 30 900 | <5 | 135 | 1 848 | 190 135 | 2.5 | 0.7 | 1.8 (−0.8 to 4.3) | 2.33 (0.82-6.62) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 55 | 1 115 | 115 324 | 3.0 | 0.5 | 2.5 (−1.0 to 6.0) | 4.19 (1.21-14.50) |
| Women, aged ≥55 y | 43 | 4 217 | 0 | 26 | 214 | 20 972 | 0.0 | 1.3 | −1.3 (−1.8 to −0.8) | — |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 24 | 355 | 36 578 | 3.6 | 0.7 | 2.9 (−4.1 to 9.9) | 3.99 (0.44-35.96) |
| Men, aged ≥55 y | 36 | 3 570 | 0 | 30 | 164 | 17 261 | 0.0 | 1.6 | −1.6 (−2.2 to −1.0) | — |
| Myocardial infarction | ||||||||||
| All | 309 | 30 900 | <5 | 212 | 1 853 | 189 831 | 0.7 | 1.1 | −0.4 (−1.4 to 0.7) | 0.83 (0.20-3.37) |
| Women, aged 18-54 y | 174 | 17 483 | 0 | 31 | 1 129 | 115 443 | 0.0 | 0.3 | −0.3 (−0.4 to −0.2) | — |
| Women, aged ≥55 y | 43 | 4 217 | 0 | 61 | 214 | 20 817 | 0.0 | 2.8 | −2.8 (−3.5 to −2.0) | — |
| Men, aged 18-54 y | 56 | 5 630 | 0 | 49 | 356 | 36 457 | 0.0 | 1.3 | −1.3 (−1.7 to −0.9) | — |
| Men, aged ≥55 y | 36 | 3 570 | <5 | 71 | 155 | 17 114 | 6.9 | 4.2 | 2.7 (−6.6 to 12.1) | 2.74 (0.64-11.64) |
| Ischemic stroke | ||||||||||
| All | 309 | 30 900 | 6 | 195 | 1 839 | 190 069 | 2.3 | 1.1 | 1.2 (−0.6 to 3.1) | 3.21 (1.41-7.31) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 24 | 1 127 | 115 460 | 0.6 | 0.2 | 0.4 (−0.8 to 1.6) | 4.53 (0.56-36.83) |
| Women, aged ≥55 y | 43 | 4 217 | <5 | 68 | 196 | 20 895 | 11.0 | 3.6 | 7.5 (−3.0 to 17.9) | 4.67 (1.58-13.81) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 28 | 352 | 36 543 | 2.5 | 0.8 | 1.7 (−3.1 to 6.6) | 3.16 (0.42-23.60) |
| Men, aged ≥55 y | 36 | 3 570 | 0 | 75 | 164 | 17 171 | 0.0 | 4.3 | −4.3 (−5.4 to −3.3) | — |
| Major bleeding | ||||||||||
| All | 309 | 30 900 | 8 | 307 | 1 849 | 189 674 | 5.1 | 1.7 | 3.4 (−0.2 to 7.0) | 2.56 (1.26-5.20) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 88 | 1 126 | 115 235 | 1.0 | 0.8 | 0.1 (−1.7 to 2.0) | 1.16 (0.16-8.46) |
| Women, aged ≥55 y | 43 | 4 217 | <5 | 76 | 207 | 20 828 | 16.8 | 3.8 | 13.1 (−5.1 to 31.2) | 3.82 (1.18-12.42) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 48 | 354 | 36 500 | 11.0 | 1.4 | 9.6 (−2.5 to 21.7) | 4.68 (1.36-16.11) |
| Men, aged ≥55 y | 36 | 3 570 | <5 | 95 | 162 | 17 110 | 3.1 | 5.5 | −2.3 (−8.5 to 3.8) | 1.11 (0.15-8.24) |
| All-cause mortality | ||||||||||
| All | 309 | 30 900 | 18 | 876 | 1 863 | 190 623 | 10.3 | 4.8 | 5.5 (0.7-10.3) | 2.01 (1.25-3.24) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 107 | 1 129 | 115 553 | 2.2 | 1.0 | 1.1 (−1.4 to 3.6) | 1.82 (0.53-6.18) |
| Women, aged ≥55 y | 43 | 4 217 | 7 | 358 | 214 | 21 054 | 41.7 | 18.4 | 23.3 (−1.9 to 48.5) | 1.86 (0.86-4.01) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 75 | 356 | 36 663 | 9.6 | 2.1 | 7.4 (−3.1 to 18.0) | 2.27 (0.64-8.03) |
| Men, aged ≥55 y | 36 | 3 570 | 5 | 336 | 164 | 17 353 | 24.9 | 19.9 | 5.0 (−15.2 to 25.2) | 1.93 (0.79-4.71) |
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR (95% CI)∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference (95% CI) . | ||
| CVT recurrence | ||||||||||
| All | 309 | 30 900 | 5 | — | 1 831 | — | 2.4 | — | — | — |
| Women, aged 18-54 y | 174 | 17 483 | <5 | — | 1 102 | — | 3.2 | — | — | — |
| Women, aged ≥55 y | 43 | 4 217 | 0 | — | 214 | — | — | — | — | — |
| Men, aged 18-54 y | 56 | 5 630 | <5 | — | 352 | — | 2.6 | — | — | — |
| Men, aged ≥55 y | 36 | 3 570 | 0 | — | 164 | — | — | — | — | — |
| VTE | ||||||||||
| All | 309 | 30 900 | <5 | 135 | 1 848 | 190 135 | 2.5 | 0.7 | 1.8 (−0.8 to 4.3) | 2.33 (0.82-6.62) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 55 | 1 115 | 115 324 | 3.0 | 0.5 | 2.5 (−1.0 to 6.0) | 4.19 (1.21-14.50) |
| Women, aged ≥55 y | 43 | 4 217 | 0 | 26 | 214 | 20 972 | 0.0 | 1.3 | −1.3 (−1.8 to −0.8) | — |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 24 | 355 | 36 578 | 3.6 | 0.7 | 2.9 (−4.1 to 9.9) | 3.99 (0.44-35.96) |
| Men, aged ≥55 y | 36 | 3 570 | 0 | 30 | 164 | 17 261 | 0.0 | 1.6 | −1.6 (−2.2 to −1.0) | — |
| Myocardial infarction | ||||||||||
| All | 309 | 30 900 | <5 | 212 | 1 853 | 189 831 | 0.7 | 1.1 | −0.4 (−1.4 to 0.7) | 0.83 (0.20-3.37) |
| Women, aged 18-54 y | 174 | 17 483 | 0 | 31 | 1 129 | 115 443 | 0.0 | 0.3 | −0.3 (−0.4 to −0.2) | — |
| Women, aged ≥55 y | 43 | 4 217 | 0 | 61 | 214 | 20 817 | 0.0 | 2.8 | −2.8 (−3.5 to −2.0) | — |
| Men, aged 18-54 y | 56 | 5 630 | 0 | 49 | 356 | 36 457 | 0.0 | 1.3 | −1.3 (−1.7 to −0.9) | — |
| Men, aged ≥55 y | 36 | 3 570 | <5 | 71 | 155 | 17 114 | 6.9 | 4.2 | 2.7 (−6.6 to 12.1) | 2.74 (0.64-11.64) |
| Ischemic stroke | ||||||||||
| All | 309 | 30 900 | 6 | 195 | 1 839 | 190 069 | 2.3 | 1.1 | 1.2 (−0.6 to 3.1) | 3.21 (1.41-7.31) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 24 | 1 127 | 115 460 | 0.6 | 0.2 | 0.4 (−0.8 to 1.6) | 4.53 (0.56-36.83) |
| Women, aged ≥55 y | 43 | 4 217 | <5 | 68 | 196 | 20 895 | 11.0 | 3.6 | 7.5 (−3.0 to 17.9) | 4.67 (1.58-13.81) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 28 | 352 | 36 543 | 2.5 | 0.8 | 1.7 (−3.1 to 6.6) | 3.16 (0.42-23.60) |
| Men, aged ≥55 y | 36 | 3 570 | 0 | 75 | 164 | 17 171 | 0.0 | 4.3 | −4.3 (−5.4 to −3.3) | — |
| Major bleeding | ||||||||||
| All | 309 | 30 900 | 8 | 307 | 1 849 | 189 674 | 5.1 | 1.7 | 3.4 (−0.2 to 7.0) | 2.56 (1.26-5.20) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 88 | 1 126 | 115 235 | 1.0 | 0.8 | 0.1 (−1.7 to 2.0) | 1.16 (0.16-8.46) |
| Women, aged ≥55 y | 43 | 4 217 | <5 | 76 | 207 | 20 828 | 16.8 | 3.8 | 13.1 (−5.1 to 31.2) | 3.82 (1.18-12.42) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 48 | 354 | 36 500 | 11.0 | 1.4 | 9.6 (−2.5 to 21.7) | 4.68 (1.36-16.11) |
| Men, aged ≥55 y | 36 | 3 570 | <5 | 95 | 162 | 17 110 | 3.1 | 5.5 | −2.3 (−8.5 to 3.8) | 1.11 (0.15-8.24) |
| All-cause mortality | ||||||||||
| All | 309 | 30 900 | 18 | 876 | 1 863 | 190 623 | 10.3 | 4.8 | 5.5 (0.7-10.3) | 2.01 (1.25-3.24) |
| Women, aged 18-54 y | 174 | 17 483 | <5 | 107 | 1 129 | 115 553 | 2.2 | 1.0 | 1.1 (−1.4 to 3.6) | 1.82 (0.53-6.18) |
| Women, aged ≥55 y | 43 | 4 217 | 7 | 358 | 214 | 21 054 | 41.7 | 18.4 | 23.3 (−1.9 to 48.5) | 1.86 (0.86-4.01) |
| Men, aged 18-54 y | 56 | 5 630 | <5 | 75 | 356 | 36 663 | 9.6 | 2.1 | 7.4 (−3.1 to 18.0) | 2.27 (0.64-8.03) |
| Men, aged ≥55 y | 36 | 3 570 | 5 | 336 | 164 | 17 353 | 24.9 | 19.9 | 5.0 (−15.2 to 25.2) | 1.93 (0.79-4.71) |
Controlled for matching factors (age, sex, and calendar period) by design and adjusted for cancer, recent infection, fracture/trauma, surgery, or pregnancy, previous VTE, myocardial infarction, ischemic and hemorrhagic stroke, major bleeding, other ischemic heart disease, atrial fibrillation, hypertension, diabetes, obesity, peripheral artery disease, chronic liver disease, and chronic pulmonary disease.